EC Number | Cloned (Comment) | Organism |
---|---|---|
2.3.1.41 | expression of His-tagged FabH1 and FabH2 in Escherichia coli INValphaF' | Bacillus subtilis |
2.3.1.180 | genes fabH1 and fabH2, expression of His-tagged enzymes in Escherichia coli strain BL21(DE3) | Bacillus subtilis |
EC Number | Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|---|
2.3.1.41 | additional information | - |
amino acid sequence alignment | Bacillus subtilis |
2.3.1.41 | additional information | - |
amino acid sequence alignment | Escherichia coli |
2.3.1.41 | 39800 | - |
x * 39800, FabH2, SDS-PAGE | Bacillus subtilis |
2.3.1.41 | 42700 | - |
x * 42700, FabH1, SDS-PAGE | Bacillus subtilis |
EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
2.3.1.41 | acyl-[acyl-carrier protein] + malonyl-[acyl-carrier protein] | Escherichia coli | - |
3-oxoacyl-[acyl-carrier protein] + CO2 + [acyl-carrier protein] | - |
? | |
2.3.1.41 | acyl-[acyl-carrier protein] + malonyl-[acyl-carrier protein] | Bacillus subtilis | initiation of fatty acid biosynthesis with acetyl-CoA as a primer, overview substrate specificity | 3-oxoacyl-[acyl-carrier protein] + CO2 + [acyl-carrier protein] | - |
? |
EC Number | Organism | UniProt | Comment | Textmining |
---|---|---|---|---|
2.3.1.41 | Bacillus subtilis | - |
genes fabH1 and fabH2, 2 synthase III isozymes | - |
2.3.1.41 | Escherichia coli | - |
synthase III, gene fabH | - |
2.3.1.180 | Bacillus subtilis | - |
genes fabH1 and fabH2 encoding isozymes FabH1 and FabH2 | - |
EC Number | Purification (Comment) | Organism |
---|---|---|
2.3.1.41 | recombinant His-tagged proteins FabH1 and FabH2 from E. coli | Bacillus subtilis |
EC Number | Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
---|---|---|---|---|
2.3.1.41 | additional information | - |
- |
Bacillus subtilis |
2.3.1.41 | additional information | - |
- |
Escherichia coli |
2.3.1.180 | additional information | - |
substrate specificities of FabH1 and FabH2 | Bacillus subtilis |
2.3.1.180 | 0.024 | - |
purified recombinant His-tagged isoyzme FabH1, primer substrate acetyl-CoA | Bacillus subtilis |
2.3.1.180 | 0.105 | - |
purified recombinant His-tagged isoyzme FabH2, primer substrate acetyl-CoA | Bacillus subtilis |
2.3.1.180 | 0.155 | - |
purified recombinant His-tagged isoyzme FabH1, primer substrate 2-methylbutyryl-CoA | Bacillus subtilis |
2.3.1.180 | 0.162 | - |
purified recombinant His-tagged isoyzme FabH2, primer substrate isovaleryl-CoA | Bacillus subtilis |
EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
2.3.1.41 | acyl-[acyl-carrier protein] + malonyl-[acyl-carrier protein] | - |
Escherichia coli | 3-oxoacyl-[acyl-carrier protein] + CO2 + [acyl-carrier protein] | - |
? | |
2.3.1.41 | acyl-[acyl-carrier protein] + malonyl-[acyl-carrier protein] | initiation of fatty acid biosynthesis with acetyl-CoA as a primer, overview substrate specificity | Bacillus subtilis | 3-oxoacyl-[acyl-carrier protein] + CO2 + [acyl-carrier protein] | - |
? | |
2.3.1.41 | additional information | - |
Escherichia coli | ? | - |
? | |
2.3.1.41 | additional information | synthase III isozymes also utilize iso- and anteiso-branched-chain acyl-CoA primers as substrates | Bacillus subtilis | ? | - |
? | |
2.3.1.41 | saturated acyl-[acyl-carrier protein] + malonyl-[acyl-carrier protein] | substrate specificity, overview | Bacillus subtilis | 3-oxoacyl-[acyl-carrier protein] + CO2 + [acyl-carrier protein] | - |
? | |
2.3.1.41 | saturated acyl-[acyl-carrier protein] + malonyl-[acyl-carrier protein] | substrate specificity, overview | Escherichia coli | 3-oxoacyl-[acyl-carrier protein] + CO2 + [acyl-carrier protein] | - |
? | |
2.3.1.180 | 2-methylbutyryl-CoA + malonyl-[acyl-carrier protein] | 2-methylbutyryl-CoA is the preferred primer substrate of isozyme FabH1 | Bacillus subtilis | 3-oxo-4-methyl-hexanoyl-[acyl-carrier protein] + CoA + CO2 | - |
? | |
2.3.1.180 | acetyl-CoA + malonyl-[acyl-carrier protein] | - |
Bacillus subtilis | acetoacetyl-[acyl-carrier protein] + CoA + CO2 | - |
? | |
2.3.1.180 | butyryl-CoA + malonyl-[acyl-carrier protein] | - |
Bacillus subtilis | 3-oxo-hexanoyl-[acyl-carrier protein] + CoA + CO2 | - |
? | |
2.3.1.180 | heptanoyl-CoA + malonyl-[acyl-carrier protein] | - |
Bacillus subtilis | 3-oxo-nonanoyl-[acyl-carrier protein] + CoA + CO2 | - |
? | |
2.3.1.180 | hexanoyl-CoA + malonyl-[acyl-carrier protein] | - |
Bacillus subtilis | 3-oxo-octanoyl-[acyl-carrier protein] + CoA + CO2 | - |
? | |
2.3.1.180 | isobutyryl-CoA + malonyl-[acyl-carrier protein] | - |
Bacillus subtilis | 3-oxo-4-methyl-pentanoyl-[acyl-carrier protein] + CoA + CO2 | - |
? | |
2.3.1.180 | isovaleryl-CoA + malonyl-[acyl-carrier protein] | isovaleryl-CoA is the preferred primer substrate of isozyme FabH2 | Bacillus subtilis | 3-oxo-5-methyl-hexanoyl-[acyl-carrier protein] + CoA + CO2 | - |
? | |
2.3.1.180 | additional information | substrate specificities of FabH1 and FabH2 with different primer substrates, both isozymes prefer branched-chain fatty acids | Bacillus subtilis | ? | - |
? | |
2.3.1.180 | octanoyl-CoA + malonyl-[acyl-carrier protein] | low activity with octanoyl-CoA as primer substrate of isozyme FabH1, no activity with FabH2 | Bacillus subtilis | 3-oxo-decanoyl-[acyl-carrier protein] + CoA + CO2 | - |
? | |
2.3.1.180 | propionyl-CoA + malonyl-[acyl-carrier protein] | - |
Bacillus subtilis | 3-oxo-valeryl-[acyl-carrier protein] + CoA + CO2 | - |
? | |
2.3.1.180 | valeryl-CoA + malonyl-[acyl-carrier protein] | - |
Bacillus subtilis | 3-oxo-heptanoyl-[acyl-carrier protein] + CoA + CO2 | - |
? |
EC Number | Subunits | Comment | Organism |
---|---|---|---|
2.3.1.41 | ? | x * 42700, FabH1, SDS-PAGE | Bacillus subtilis |
2.3.1.41 | ? | x * 39800, FabH2, SDS-PAGE | Bacillus subtilis |
EC Number | Synonyms | Comment | Organism |
---|---|---|---|
2.3.1.180 | beta-ketoacyl-acyl carrier protein synthase III | - |
Bacillus subtilis |
2.3.1.180 | FabH | - |
Bacillus subtilis |
EC Number | Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|---|
2.3.1.41 | 37 | - |
assay at | Bacillus subtilis |
2.3.1.41 | 37 | - |
assay at | Escherichia coli |
2.3.1.180 | 37 | - |
assay at | Bacillus subtilis |
EC Number | pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|---|
2.3.1.41 | 7 | - |
assay at | Bacillus subtilis |
2.3.1.41 | 7 | - |
assay at | Escherichia coli |
2.3.1.180 | 7 | - |
assay at | Bacillus subtilis |