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Literature summary extracted from

  • Davison, E.A.; Blumenthal, H.J.; Roseman, S.
    Glucosamine metabolism. II. Studies on glucosamine 6-phosphate N-acetylase (1957), J. Biol. Chem., 226, 125-133.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.3.1.4 additional information not inhibited by EDTA; not inhibited by iodoacetate Neurospora crassa
2.3.1.4 p-chloromercuribenzoate 1 mM, complete inhibition Neurospora crassa

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
2.3.1.4 0.78
-
 acetyl-CoA
-
 Neurospora crassa
2.3.1.4 0.78
-
 D-glucosamine 6-phosphate
-
 Neurospora crassa

Organism

EC Number Organism UniProt Comment Textmining
2.3.1.4 Canis lupus familiaris
-
-
-
2.3.1.4 Homo sapiens
-
-
-
2.3.1.4 Neurospora crassa
-
-
-
2.3.1.4 Oryctolagus cuniculus
-
-
-
2.3.1.4 Penicillium sp.
-
-
-
2.3.1.4 Streptococcus sp.
-
 hemolytic, group A
-

Purification (Commentary)

EC Number Purification (Comment) Organism
2.3.1.4 calcium phosphate gel, heat treatment, 60°C, mixed bed resin, alumina Cgamma gel, ammonium sulfate Neurospora crassa

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.3.1.4 kidney
-
 Oryctolagus cuniculus
-
2.3.1.4 kidney
-
 Canis lupus familiaris
-
2.3.1.4 liver
-
 Homo sapiens
-
2.3.1.4 liver
-
 Oryctolagus cuniculus
-
2.3.1.4 liver
-
 Canis lupus familiaris
-
2.3.1.4 liver
-
 Penicillium sp.
-
2.3.1.4 muscle
-
 Oryctolagus cuniculus
-

Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
2.3.1.4 12.21
-
-
 Neurospora crassa

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.3.1.4 acetyl-CoA + D-glucosamine 6-phosphate
-
 Homo sapiens CoA + N-acetyl-D-glucosamine 6-phosphate
-
 ?
2.3.1.4 acetyl-CoA + D-glucosamine 6-phosphate
-
 Oryctolagus cuniculus CoA + N-acetyl-D-glucosamine 6-phosphate
-
 ?
2.3.1.4 acetyl-CoA + D-glucosamine 6-phosphate
-
 Neurospora crassa CoA + N-acetyl-D-glucosamine 6-phosphate
-
 ?
2.3.1.4 acetyl-CoA + D-glucosamine 6-phosphate
-
 Canis lupus familiaris CoA + N-acetyl-D-glucosamine 6-phosphate
-
 ?
2.3.1.4 acetyl-CoA + D-glucosamine 6-phosphate
-
 Penicillium sp. CoA + N-acetyl-D-glucosamine 6-phosphate
-
 ?
2.3.1.4 acetyl-CoA + D-glucosamine 6-phosphate
-
 Streptococcus sp. CoA + N-acetyl-D-glucosamine 6-phosphate
-
 ?

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
2.3.1.4 6 7.1
-
 Neurospora crassa

Cofactor

EC Number Cofactor Comment Organism Structure
2.3.1.4 additional information no cofactor required Neurospora crassa