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Literature summary extracted from

  • Summers, R.G.; Ali, A.; Shen, B.; Wessel, W.A.; Hutchinson, C.R.
    Malonyl-coenzyme A:acyl carrier protein acyltransferase of Streptomyces glaucescens: a possible link between fatty acid and polyketide biosynthesis (1995), Biochemistry, 34, 9389-9402.
    View publication on PubMed

Cloned(Commentary)

EC Number Cloned (Comment) Organism
2.3.1.39 expression of the enzyme gene in Escherichia coli Streptomyces glaucescens

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.3.1.39 additional information Streptomyces glaucescens the enzyme is responsible for charging the tetracenomycin M acyl-carrier-protein with malonate in vivo, a key step in the synthesis of the deca(polyketide) precursor of tetracenomycin C. This implies the existence of a functional connection between fatty acid and polyketide metabolism in this bacterium ?
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 ?

Organism

EC Number Organism UniProt Comment Textmining
2.3.1.39 Streptomyces glaucescens
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 produces tetracenomicin C
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Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.3.1.39 malonyl-CoA + acyl-carrier protein the recombinant enzyme is able to use E. coli acyl-carrier-protein, Streptomyces glaucescens acyl-carrier-protein as well as the tetracenomycin M acyl-carrier-protein component of the tetracenomycin type II polyketide synthase Streptomyces glaucescens CoA + malonyl-[acyl-carrier protein]
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 ?
2.3.1.39 malonyl-CoA + acyl-carrier protein characterization of acyl-carrier protein Streptomyces glaucescens CoA + malonyl-[acyl-carrier protein]
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 ?
2.3.1.39 additional information the enzyme is responsible for charging the tetracenomycin M acyl-carrier-protein with malonate in vivo, a key step in the synthesis of the deca(polyketide) precursor of tetracenomycin C. This implies the existence of a functional connection between fatty acid and polyketide metabolism in this bacterium Streptomyces glaucescens ?
-
 ?

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
2.3.1.39 8
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 assay at Streptomyces glaucescens