BRENDA - Enzyme Database show

Involvement of delta-aminolevulinate synthase encoded by the parasite gene in de novo heme synthesis by Plasmodium falciparum

Varadharajan, S.; Dhanasekaran, S.; Bonday, Z.Q.; Rangarajan, P.N.; Padmanaban, G.; Biochem. J. 367, 321-327 (2002)

Data extracted from this reference:

Application
EC Number
Application
Commentary
Organism
2.3.1.37
pharmacology
enzyme is a target for drug development because of its immunological and inhibitor specificity
Plasmodium falciparum
Cloned(Commentary)
EC Number
Commentary
Organism
2.3.1.37
expression in Escherichia coli
Plasmodium falciparum
Inhibitors
EC Number
Inhibitors
Commentary
Organism
Structure
2.3.1.37
aminomalonate
weak
Plasmodium falciparum
2.3.1.37
ethanolamine
-
Plasmodium falciparum
2.3.1.37
hemin
inhibition of the import of the enzyme into the mitochondrial matrix
Plasmodium falciparum
KM Value [mM]
EC Number
KM Value [mM]
KM Value Maximum [mM]
Substrate
Commentary
Organism
Structure
2.3.1.37
0.1
-
succinyl-CoA
recombinant enzyme
Plasmodium falciparum
2.3.1.37
50
-
glycine
recombinant enzyme
Plasmodium falciparum
Localization
EC Number
Localization
Commentary
Organism
GeneOntology No.
Textmining
2.3.1.37
mitochondrion
-
Plasmodium falciparum
5739
-
Molecular Weight [Da]
EC Number
Molecular Weight [Da]
Molecular Weight Maximum [Da]
Commentary
Organism
2.3.1.37
63000
-
x * 63000, about, SDS-PAGE
Plasmodium falciparum
2.3.1.37
158000
-
gel filtration
Plasmodium falciparum
Natural Substrates/ Products (Substrates)
EC Number
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
2.3.1.37
succinyl-CoA + glycine
Plasmodium falciparum
-
5-aminolevulinate + CoA + CO2
-
Plasmodium falciparum
?
Organism
EC Number
Organism
Primary Accession No. (UniProt)
Commentary
Textmining
2.3.1.37
Plasmodium falciparum
-
-
-
Source Tissue
EC Number
Source Tissue
Commentary
Organism
Textmining
2.3.1.37
additional information
import into mitochondria
Plasmodium falciparum
-
Substrates and Products (Substrate)
EC Number
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
2.3.1.37
succinyl-CoA + glycine
-
486860
Plasmodium falciparum
5-aminolevulinate + CoA + CO2
-
486860
Plasmodium falciparum
?
Subunits
EC Number
Subunits
Commentary
Organism
2.3.1.37
?
x * 63000, about, SDS-PAGE
Plasmodium falciparum
Application (protein specific)
EC Number
Application
Commentary
Organism
2.3.1.37
pharmacology
enzyme is a target for drug development because of its immunological and inhibitor specificity
Plasmodium falciparum
Cloned(Commentary) (protein specific)
EC Number
Commentary
Organism
2.3.1.37
expression in Escherichia coli
Plasmodium falciparum
Inhibitors (protein specific)
EC Number
Inhibitors
Commentary
Organism
Structure
2.3.1.37
aminomalonate
weak
Plasmodium falciparum
2.3.1.37
ethanolamine
-
Plasmodium falciparum
2.3.1.37
hemin
inhibition of the import of the enzyme into the mitochondrial matrix
Plasmodium falciparum
KM Value [mM] (protein specific)
EC Number
KM Value [mM]
KM Value Maximum [mM]
Substrate
Commentary
Organism
Structure
2.3.1.37
0.1
-
succinyl-CoA
recombinant enzyme
Plasmodium falciparum
2.3.1.37
50
-
glycine
recombinant enzyme
Plasmodium falciparum
Localization (protein specific)
EC Number
Localization
Commentary
Organism
GeneOntology No.
Textmining
2.3.1.37
mitochondrion
-
Plasmodium falciparum
5739
-
Molecular Weight [Da] (protein specific)
EC Number
Molecular Weight [Da]
Molecular Weight Maximum [Da]
Commentary
Organism
2.3.1.37
63000
-
x * 63000, about, SDS-PAGE
Plasmodium falciparum
2.3.1.37
158000
-
gel filtration
Plasmodium falciparum
Natural Substrates/ Products (Substrates) (protein specific)
EC Number
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
2.3.1.37
succinyl-CoA + glycine
Plasmodium falciparum
-
5-aminolevulinate + CoA + CO2
-
Plasmodium falciparum
?
Source Tissue (protein specific)
EC Number
Source Tissue
Commentary
Organism
Textmining
2.3.1.37
additional information
import into mitochondria
Plasmodium falciparum
-
Substrates and Products (Substrate) (protein specific)
EC Number
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
2.3.1.37
succinyl-CoA + glycine
-
486860
Plasmodium falciparum
5-aminolevulinate + CoA + CO2
-
486860
Plasmodium falciparum
?
Subunits (protein specific)
EC Number
Subunits
Commentary
Organism
2.3.1.37
?
x * 63000, about, SDS-PAGE
Plasmodium falciparum