EC Number | Application | Comment | Organism |
---|---|---|---|
2.3.1.37 | pharmacology | enzyme is a target for drug development because of its immunological and inhibitor specificity | Plasmodium falciparum |
EC Number | Cloned (Comment) | Organism |
---|---|---|
2.3.1.37 | expression in Escherichia coli | Plasmodium falciparum |
EC Number | Inhibitors | Comment | Organism | Structure |
---|---|---|---|---|
2.3.1.37 | aminomalonate | weak | Plasmodium falciparum | |
2.3.1.37 | ethanolamine | - |
Plasmodium falciparum | |
2.3.1.37 | hemin | inhibition of the import of the enzyme into the mitochondrial matrix | Plasmodium falciparum |
EC Number | KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|---|
2.3.1.37 | 0.1 | - |
succinyl-CoA | recombinant enzyme | Plasmodium falciparum | |
2.3.1.37 | 50 | - |
glycine | recombinant enzyme | Plasmodium falciparum |
EC Number | Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|---|
2.3.1.37 | mitochondrion | - |
Plasmodium falciparum | 5739 | - |
EC Number | Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|---|
2.3.1.37 | 63000 | - |
x * 63000, about, SDS-PAGE | Plasmodium falciparum |
2.3.1.37 | 158000 | - |
gel filtration | Plasmodium falciparum |
EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
2.3.1.37 | succinyl-CoA + glycine | Plasmodium falciparum | - |
5-aminolevulinate + CoA + CO2 | - |
? |
EC Number | Organism | UniProt | Comment | Textmining |
---|---|---|---|---|
2.3.1.37 | Plasmodium falciparum | - |
- |
- |
EC Number | Source Tissue | Comment | Organism | Textmining |
---|---|---|---|---|
2.3.1.37 | additional information | import into mitochondria | Plasmodium falciparum | - |
EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
2.3.1.37 | succinyl-CoA + glycine | - |
Plasmodium falciparum | 5-aminolevulinate + CoA + CO2 | - |
? |
EC Number | Subunits | Comment | Organism |
---|---|---|---|
2.3.1.37 | ? | x * 63000, about, SDS-PAGE | Plasmodium falciparum |