BRENDA - Enzyme Database show

Lysine-313 of 5-aminolevulinate synthase acts as a general base during formation of the quinonoid reaction intermediates

Hunter, G.A.; Ferreira, G.C.; Biochemistry 38, 3711-3718 (1999)

Data extracted from this reference:

Engineering
EC Number
Amino acid exchange
Commentary
Organism
2.3.1.37
K313H
formation of quinonoid reaction intermediates
Mus musculus
2.3.1.37
K313R
formation of quinonoid reaction intermediates
Mus musculus
Natural Substrates/ Products (Substrates)
EC Number
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
2.3.1.37
succinyl-CoA + glycine
Mus musculus
first step in heme biosynthesis pathway
5-aminolevulinate + CoA + CO2
-
Mus musculus
?
2.3.1.37
succinyl-CoA + glycine
Mus musculus
rate-limiting enzyme of heme biosynthesis
5-aminolevulinate + CoA + CO2
-
Mus musculus
?
Organism
EC Number
Organism
Primary Accession No. (UniProt)
Commentary
Textmining
2.3.1.37
Mus musculus
-
erythroid-specific isoform
-
Reaction
EC Number
Reaction
Commentary
Organism
2.3.1.37
succinyl-CoA + glycine = 5-aminolevulinate + CoA + CO2
Lys313 acts as a general base during formation of the quinonoid reaction intermediates; mechanism
Mus musculus
Substrates and Products (Substrate)
EC Number
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
2.3.1.37
succinyl-CoA + glycine
-
486859
Mus musculus
5-aminolevulinate + CoA + CO2
-
486859
Mus musculus
?
2.3.1.37
succinyl-CoA + glycine
first step in heme biosynthesis pathway
486859
Mus musculus
5-aminolevulinate + CoA + CO2
-
486859
Mus musculus
?
2.3.1.37
succinyl-CoA + glycine
rate-limiting enzyme of heme biosynthesis
486859
Mus musculus
5-aminolevulinate + CoA + CO2
-
486859
Mus musculus
?
Cofactor
EC Number
Cofactor
Commentary
Organism
Structure
2.3.1.37
pyridoxal 5'-phosphate
-
Mus musculus
Cofactor (protein specific)
EC Number
Cofactor
Commentary
Organism
Structure
2.3.1.37
pyridoxal 5'-phosphate
-
Mus musculus
Engineering (protein specific)
EC Number
Amino acid exchange
Commentary
Organism
2.3.1.37
K313H
formation of quinonoid reaction intermediates
Mus musculus
2.3.1.37
K313R
formation of quinonoid reaction intermediates
Mus musculus
Natural Substrates/ Products (Substrates) (protein specific)
EC Number
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
2.3.1.37
succinyl-CoA + glycine
Mus musculus
first step in heme biosynthesis pathway
5-aminolevulinate + CoA + CO2
-
Mus musculus
?
2.3.1.37
succinyl-CoA + glycine
Mus musculus
rate-limiting enzyme of heme biosynthesis
5-aminolevulinate + CoA + CO2
-
Mus musculus
?
Substrates and Products (Substrate) (protein specific)
EC Number
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
2.3.1.37
succinyl-CoA + glycine
-
486859
Mus musculus
5-aminolevulinate + CoA + CO2
-
486859
Mus musculus
?
2.3.1.37
succinyl-CoA + glycine
first step in heme biosynthesis pathway
486859
Mus musculus
5-aminolevulinate + CoA + CO2
-
486859
Mus musculus
?
2.3.1.37
succinyl-CoA + glycine
rate-limiting enzyme of heme biosynthesis
486859
Mus musculus
5-aminolevulinate + CoA + CO2
-
486859
Mus musculus
?