BRENDA - Enzyme Database show

Biphasic ordered induction of heme synthesis in differentiating murine erythroleukemia cells: role of erythroid 5-aminolevulinate synthase

Lake-Bullock, H.; Dailey, H.A.; Mol. Cell. Biol. 13, 7122-7132 (1993)

Data extracted from this reference:

Activating Compound
EC Number
Activating Compound
Commentary
Organism
Structure
2.3.1.37
Butyric acid
induction of enzyme expression, erythroleukemia cells
Mus musculus
2.3.1.37
Dimethylsulfoxide
induction of enzyme expression, erythroleukemia cells
Mus musculus
2.3.1.37
hexamethylene diacetamide
induction of enzyme expression, erythroleukemia cells
Mus musculus
Cloned(Commentary)
EC Number
Commentary
Organism
2.3.1.37
expression of erythroid-specific isoform in MEL mutant under control of metallothionin promotor
Mus musculus
Engineering
EC Number
Amino acid exchange
Commentary
Organism
2.3.1.37
additional information
expression of erythroid-specific isoform in MEL mutant under control of metallothionin promotor results in induction of enzyme activity by addition of Zn2+ and Cd2+ in absence of DMSO; stable MEL mutant, no induction of enzyme expression by dimethylsulfoxide, hexamethylene diacetamide and butyric acid, decline of enzyme activity after DMSO application
Mus musculus
Natural Substrates/ Products (Substrates)
EC Number
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
2.3.1.37
succinyl-CoA + glycine
Mus musculus
cellular iron status plays a regulatory role
5-aminolevulinate + CoA + CO2
-
Mus musculus
?
2.3.1.37
succinyl-CoA + glycine
Mus musculus
rate-limiting enzyme of heme biosynthesis
5-aminolevulinate + CoA + CO2
-
Mus musculus
?
Organism
EC Number
Organism
Primary Accession No. (UniProt)
Commentary
Textmining
2.3.1.37
Mus musculus
-
inducible in erythroleukemia cells
-
Source Tissue
EC Number
Source Tissue
Commentary
Organism
Textmining
2.3.1.37
erythroleukemia cell line
erythroid-specific isoform
Mus musculus
-
Substrates and Products (Substrate)
EC Number
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
2.3.1.37
succinyl-CoA + glycine
-
486847
Mus musculus
5-aminolevulinate + CoA + CO2
-
486847
Mus musculus
?
2.3.1.37
succinyl-CoA + glycine
cellular iron status plays a regulatory role
486847
Mus musculus
5-aminolevulinate + CoA + CO2
-
486847
Mus musculus
?
2.3.1.37
succinyl-CoA + glycine
rate-limiting enzyme of heme biosynthesis
486847
Mus musculus
5-aminolevulinate + CoA + CO2
-
486847
Mus musculus
?
Cofactor
EC Number
Cofactor
Commentary
Organism
Structure
2.3.1.37
pyridoxal 5'-phosphate
-
Mus musculus
Activating Compound (protein specific)
EC Number
Activating Compound
Commentary
Organism
Structure
2.3.1.37
Butyric acid
induction of enzyme expression, erythroleukemia cells
Mus musculus
2.3.1.37
Dimethylsulfoxide
induction of enzyme expression, erythroleukemia cells
Mus musculus
2.3.1.37
hexamethylene diacetamide
induction of enzyme expression, erythroleukemia cells
Mus musculus
Cloned(Commentary) (protein specific)
EC Number
Commentary
Organism
2.3.1.37
expression of erythroid-specific isoform in MEL mutant under control of metallothionin promotor
Mus musculus
Cofactor (protein specific)
EC Number
Cofactor
Commentary
Organism
Structure
2.3.1.37
pyridoxal 5'-phosphate
-
Mus musculus
Engineering (protein specific)
EC Number
Amino acid exchange
Commentary
Organism
2.3.1.37
additional information
expression of erythroid-specific isoform in MEL mutant under control of metallothionin promotor results in induction of enzyme activity by addition of Zn2+ and Cd2+ in absence of DMSO; stable MEL mutant, no induction of enzyme expression by dimethylsulfoxide, hexamethylene diacetamide and butyric acid, decline of enzyme activity after DMSO application
Mus musculus
Natural Substrates/ Products (Substrates) (protein specific)
EC Number
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
2.3.1.37
succinyl-CoA + glycine
Mus musculus
cellular iron status plays a regulatory role
5-aminolevulinate + CoA + CO2
-
Mus musculus
?
2.3.1.37
succinyl-CoA + glycine
Mus musculus
rate-limiting enzyme of heme biosynthesis
5-aminolevulinate + CoA + CO2
-
Mus musculus
?
Source Tissue (protein specific)
EC Number
Source Tissue
Commentary
Organism
Textmining
2.3.1.37
erythroleukemia cell line
erythroid-specific isoform
Mus musculus
-
Substrates and Products (Substrate) (protein specific)
EC Number
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
2.3.1.37
succinyl-CoA + glycine
-
486847
Mus musculus
5-aminolevulinate + CoA + CO2
-
486847
Mus musculus
?
2.3.1.37
succinyl-CoA + glycine
cellular iron status plays a regulatory role
486847
Mus musculus
5-aminolevulinate + CoA + CO2
-
486847
Mus musculus
?
2.3.1.37
succinyl-CoA + glycine
rate-limiting enzyme of heme biosynthesis
486847
Mus musculus
5-aminolevulinate + CoA + CO2
-
486847
Mus musculus
?