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Literature summary extracted from

  • Fanica-Gaignier, M.; Clement-Metral, J.
    5-Aminolevulinic-acid synthetase of Rhodopseudomonas spheroides Y. Kinetic mechanism and inhibition by ATP (1973), Eur. J. Biochem., 40, 19-24.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.3.1.37 ATP
-
 Cereibacter sphaeroides
2.3.1.37 CoA noncompetitive Cereibacter sphaeroides
2.3.1.37 delta-aminolevuinate competitive against glycine, noncompetitive against succinyl-CoA Cereibacter sphaeroides
2.3.1.37 GTP
-
 Cereibacter sphaeroides

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
2.3.1.37 additional information
-
 additional information
-
 Cereibacter sphaeroides

Organism

EC Number Organism UniProt Comment Textmining
2.3.1.37 Cereibacter sphaeroides
-
 Y
-
2.3.1.37 Cereibacter sphaeroides Y
-
 Y
-

Reaction

EC Number Reaction Comment Organism Reaction ID
2.3.1.37 succinyl-CoA + glycine = 5-aminolevulinate + CoA + CO2 mechanism Cereibacter sphaeroides
a
2.3.1.37 succinyl-CoA + glycine = 5-aminolevulinate + CoA + CO2 ordered bi-bi mechanism in which glycine binds first and 5-aminolevulinic acid dissociates last Cereibacter sphaeroides
a

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.3.1.37 succinyl-CoA + glycine
-
 Cereibacter sphaeroides 5-aminolevulinate + CoA + CO2
-
 ?
2.3.1.37 succinyl-CoA + glycine
-
 Cereibacter sphaeroides Y 5-aminolevulinate + CoA + CO2
-
 ?

Cofactor

EC Number Cofactor Comment Organism Structure
2.3.1.37 pyridoxal 5'-phosphate
-
 Cereibacter sphaeroides

Ki Value [mM]

EC Number Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
2.3.1.37 additional information
-
 additional information
-
 Cereibacter sphaeroides
2.3.1.37 0.12
-
 CoA versus glycine Cereibacter sphaeroides
2.3.1.37 0.23
-
 5-aminolevulinate versus glycine Cereibacter sphaeroides