BRENDA - Enzyme Database show

Purification and properties of solubilized mitochondrial delta-aminolevulinic acid synthetase and comparison with the cytosol enzyme

Whiting, M.J.; Elliott, W.H.; J. Biol. Chem. 247, 6818-6826 (1972)

Data extracted from this reference:

Inhibitors
EC Number
Inhibitors
Commentary
Organism
Structure
2.3.1.37
hemin
-
Cavia porcellus
2.3.1.37
hemin
feed-back inhibition
Rattus norvegicus
KM Value [mM]
EC Number
KM Value [mM]
KM Value Maximum [mM]
Substrate
Commentary
Organism
Structure
2.3.1.37
0.001
0.01
pyridoxal 5'-phosphate
-
Rattus norvegicus
2.3.1.37
0.2
-
succinyl-CoA
-
Rattus norvegicus
2.3.1.37
19
-
glycine
-
Rattus norvegicus
Localization
EC Number
Localization
Commentary
Organism
GeneOntology No.
Textmining
2.3.1.37
cytosol
-
Rattus norvegicus
5829
-
2.3.1.37
mitochondrion
-
Cavia porcellus
5739
-
2.3.1.37
mitochondrion
-
Rattus norvegicus
5739
-
2.3.1.37
additional information
-
Cavia porcellus
-
-
2.3.1.37
additional information
processing of enzyme during to targeting to subcellular compartments
Rattus norvegicus
-
-
Molecular Weight [Da]
EC Number
Molecular Weight [Da]
Molecular Weight Maximum [Da]
Commentary
Organism
2.3.1.37
77000
-
mitochondria, gel filtration
Rattus norvegicus
2.3.1.37
178000
-
cytosol, gel filtration
Rattus norvegicus
Organism
EC Number
Organism
Primary Accession No. (UniProt)
Commentary
Textmining
2.3.1.37
Cavia porcellus
-
-
-
2.3.1.37
Rattus norvegicus
-
2 isoforms in cytosol and mitochondria
-
Purification (Commentary)
EC Number
Commentary
Organism
2.3.1.37
-
Cavia porcellus
2.3.1.37
partial
Rattus norvegicus
Source Tissue
EC Number
Source Tissue
Commentary
Organism
Textmining
2.3.1.37
liver
-
Cavia porcellus
-
2.3.1.37
liver
porphyric
Rattus norvegicus
-
Storage Stability
EC Number
Storage Stability
Organism
2.3.1.37
-15C, loss of 25% activity within 10 days
Rattus norvegicus
2.3.1.37
4C, loss of 40% activity within 10 days
Rattus norvegicus
Substrates and Products (Substrate)
EC Number
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
2.3.1.37
succinyl-CoA + glycine
-
486843
Cavia porcellus
5-aminolevulinate + CoA + CO2
-
486843
Cavia porcellus
?
2.3.1.37
succinyl-CoA + glycine
-
486843
Rattus norvegicus
5-aminolevulinate + CoA + CO2
-
486843
Rattus norvegicus
?
Cofactor
EC Number
Cofactor
Commentary
Organism
Structure
2.3.1.37
pyridoxal 5'-phosphate
-
Cavia porcellus
2.3.1.37
pyridoxal 5'-phosphate
-
Rattus norvegicus
Cofactor (protein specific)
EC Number
Cofactor
Commentary
Organism
Structure
2.3.1.37
pyridoxal 5'-phosphate
-
Cavia porcellus
2.3.1.37
pyridoxal 5'-phosphate
-
Rattus norvegicus
Inhibitors (protein specific)
EC Number
Inhibitors
Commentary
Organism
Structure
2.3.1.37
hemin
-
Cavia porcellus
2.3.1.37
hemin
feed-back inhibition
Rattus norvegicus
KM Value [mM] (protein specific)
EC Number
KM Value [mM]
KM Value Maximum [mM]
Substrate
Commentary
Organism
Structure
2.3.1.37
0.001
0.01
pyridoxal 5'-phosphate
-
Rattus norvegicus
2.3.1.37
0.2
-
succinyl-CoA
-
Rattus norvegicus
2.3.1.37
19
-
glycine
-
Rattus norvegicus
Localization (protein specific)
EC Number
Localization
Commentary
Organism
GeneOntology No.
Textmining
2.3.1.37
cytosol
-
Rattus norvegicus
5829
-
2.3.1.37
mitochondrion
-
Cavia porcellus
5739
-
2.3.1.37
mitochondrion
-
Rattus norvegicus
5739
-
2.3.1.37
additional information
-
Cavia porcellus
-
-
2.3.1.37
additional information
processing of enzyme during to targeting to subcellular compartments
Rattus norvegicus
-
-
Molecular Weight [Da] (protein specific)
EC Number
Molecular Weight [Da]
Molecular Weight Maximum [Da]
Commentary
Organism
2.3.1.37
77000
-
mitochondria, gel filtration
Rattus norvegicus
2.3.1.37
178000
-
cytosol, gel filtration
Rattus norvegicus
Purification (Commentary) (protein specific)
EC Number
Commentary
Organism
2.3.1.37
-
Cavia porcellus
2.3.1.37
partial
Rattus norvegicus
Source Tissue (protein specific)
EC Number
Source Tissue
Commentary
Organism
Textmining
2.3.1.37
liver
-
Cavia porcellus
-
2.3.1.37
liver
porphyric
Rattus norvegicus
-
Storage Stability (protein specific)
EC Number
Storage Stability
Organism
2.3.1.37
-15C, loss of 25% activity within 10 days
Rattus norvegicus
2.3.1.37
4C, loss of 40% activity within 10 days
Rattus norvegicus
Substrates and Products (Substrate) (protein specific)
EC Number
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
2.3.1.37
succinyl-CoA + glycine
-
486843
Cavia porcellus
5-aminolevulinate + CoA + CO2
-
486843
Cavia porcellus
?
2.3.1.37
succinyl-CoA + glycine
-
486843
Rattus norvegicus
5-aminolevulinate + CoA + CO2
-
486843
Rattus norvegicus
?