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Literature summary extracted from

  • Sato, K.; Ishida, K.; Mutsushika, O.; Shimizu, S.
    Purification and some properties of delta-aminolevulinate acid synthases from Protaminobacter ruber and Rhodopseudomonas speroides (1985), Agric. Biol. Chem., 49, 3415-3421.
No PubMed abstract available

Activating Compound

EC Number Activating Compound Comment Organism Structure
2.3.1.37 vitamin B12 stimulates Cereibacter sphaeroides
2.3.1.37 vitamin B12 stimulates Serratia plymuthica

General Stability

EC Number General Stability Organism
2.3.1.37 holoenzyme is more stable than apoenzyme Cereibacter sphaeroides
2.3.1.37 holoenzyme is more stable than apoenzyme Serratia plymuthica
2.3.1.37 pyridoxal 5'-phosphate stabilizes Cereibacter sphaeroides
2.3.1.37 pyridoxal 5'-phosphate stabilizes Serratia plymuthica

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.3.1.37 hemin
-
 Cereibacter sphaeroides
2.3.1.37 hemin no inhibition Serratia plymuthica

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
2.3.1.37 0.00077
-
 pyridoxal 5'-phosphate
-
 Serratia plymuthica
2.3.1.37 0.015
-
 pyridoxal 5'-phosphate
-
 Cereibacter sphaeroides
2.3.1.37 1.05
-
 glycine
-
 Serratia plymuthica
2.3.1.37 8.33
-
 glycine
-
 Cereibacter sphaeroides

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
2.3.1.37 87000
-
 gel filtration Cereibacter sphaeroides
2.3.1.37 97000
-
 gel filtration Serratia plymuthica

Organism

EC Number Organism UniProt Comment Textmining
2.3.1.37 Cereibacter sphaeroides
-
-
-
2.3.1.37 Serratia plymuthica
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
2.3.1.37
-
 Cereibacter sphaeroides
2.3.1.37
-
 Serratia plymuthica

Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
2.3.1.37 0.35
-
 purified enzyme Serratia plymuthica
2.3.1.37 1.34
-
 purified enzyme Cereibacter sphaeroides

Storage Stability

EC Number Storage Stability Organism
2.3.1.37 4°C, 30 min, 50% loss of apoenzyme of Protaminobacter ruber Serratia plymuthica

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.3.1.37 succinyl-CoA + glycine
-
 Cereibacter sphaeroides 5-aminolevulinate + CoA + CO2
-
 ?
2.3.1.37 succinyl-CoA + glycine
-
 Serratia plymuthica 5-aminolevulinate + CoA + CO2
-
 ?

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
2.3.1.37 37
-
 assay at Cereibacter sphaeroides
2.3.1.37 37
-
 assay at Serratia plymuthica

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
2.3.1.37 8
-
-
 Cereibacter sphaeroides
2.3.1.37 8
-
-
 Serratia plymuthica

Cofactor

EC Number Cofactor Comment Organism Structure
2.3.1.37 pyridoxal 5'-phosphate required Cereibacter sphaeroides
2.3.1.37 pyridoxal 5'-phosphate required Serratia plymuthica