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Studies on delta-aminolevulinic acid synthase of Rhodopseudomonas spheroides. Reversibility of the reaction, kinetic, spectral, and other studies related to the mechanism of action

Nandi, D.L.; J. Biol. Chem. 253, 8872-8877 (1978)

Data extracted from this reference:

Inhibitors
EC Number
Inhibitors
Commentary
Organism
Structure
2.3.1.37
aminomalonate
competitive versus glycine
Rhodobacter sphaeroides
2.3.1.37
Aminomethylphosphonate
-
Rhodobacter sphaeroides
2.3.1.37
Borohydride
aminomalonate protects; in presence of pyridoxal 5'-phosphate
Rhodobacter sphaeroides
2.3.1.37
additional information
product inhibition pattern for the forward reaction and the reverse reaction
Rhodobacter sphaeroides
Organism
EC Number
Organism
Primary Accession No. (UniProt)
Commentary
Textmining
2.3.1.37
Rhodobacter sphaeroides
-
-
-
Reaction
EC Number
Reaction
Commentary
Organism
2.3.1.37
succinyl-CoA + glycine = 5-aminolevulinate + CoA + CO2
mechanism
Rhodobacter sphaeroides
Substrates and Products (Substrate)
EC Number
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
2.3.1.37
succinyl-CoA + glycine
glycine is formed by the reverse reaction under optimum conditions at 4-5% the rate of 5-aminolevulinate formed by the forward reaction under optimum conditions
486821
Rhodobacter sphaeroides
5-aminolevulinate + CoA + CO2
-
486821
Rhodobacter sphaeroides
r
Cofactor
EC Number
Cofactor
Commentary
Organism
Structure
2.3.1.37
pyridoxal 5'-phosphate
-
Rhodobacter sphaeroides
Ki Value [mM]
EC Number
Ki Value [mM]
Ki Value maximum [mM]
Inhibitor
Commentary
Organism
Structure
2.3.1.37
0.023
-
aminomalonate
-
Rhodobacter sphaeroides
2.3.1.37
10
-
Aminomethylphosphonate
-
Rhodobacter sphaeroides
Cofactor (protein specific)
EC Number
Cofactor
Commentary
Organism
Structure
2.3.1.37
pyridoxal 5'-phosphate
-
Rhodobacter sphaeroides
Inhibitors (protein specific)
EC Number
Inhibitors
Commentary
Organism
Structure
2.3.1.37
aminomalonate
competitive versus glycine
Rhodobacter sphaeroides
2.3.1.37
Aminomethylphosphonate
-
Rhodobacter sphaeroides
2.3.1.37
Borohydride
aminomalonate protects; in presence of pyridoxal 5'-phosphate
Rhodobacter sphaeroides
2.3.1.37
additional information
product inhibition pattern for the forward reaction and the reverse reaction
Rhodobacter sphaeroides
Ki Value [mM] (protein specific)
EC Number
Ki Value [mM]
Ki Value maximum [mM]
Inhibitor
Commentary
Organism
Structure
2.3.1.37
0.023
-
aminomalonate
-
Rhodobacter sphaeroides
2.3.1.37
10
-
Aminomethylphosphonate
-
Rhodobacter sphaeroides
Substrates and Products (Substrate) (protein specific)
EC Number
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
2.3.1.37
succinyl-CoA + glycine
glycine is formed by the reverse reaction under optimum conditions at 4-5% the rate of 5-aminolevulinate formed by the forward reaction under optimum conditions
486821
Rhodobacter sphaeroides
5-aminolevulinate + CoA + CO2
-
486821
Rhodobacter sphaeroides
r