BRENDA - Enzyme Database show

delta-Aminolevulinic acid synthetase

Jordan, P.M.; Shemin, D.; The Enzymes, 3rd Ed. (Boyer, P. D. , ed. ) 7, 339-356 (1972)
No PubMed abstract available

Data extracted from this reference:

Activating Compound
EC Number
Activating Compound
Commentary
Organism
Structure
2.3.1.37
2-allyl-2-isopropylacetamide
strong induction of enzyme in liver
Cavia porcellus
2.3.1.37
2-allyl-2-isopropylacetamide
strong induction of enzyme in liver
Gallus gallus
2.3.1.37
2-allyl-2-isopropylacetamide
strong induction of enzyme in liver
Rattus norvegicus
Inhibitors
EC Number
Inhibitors
Commentary
Organism
Structure
2.3.1.37
2-hydroxyethyldisulfide
-
Rhodobacter sphaeroides
2.3.1.37
2-mercaptoethanol
-
Oryctolagus cuniculus
2.3.1.37
2-oxoglutarate
-
Cavia porcellus
2.3.1.37
2-oxoglutarate
-
Gallus gallus
2.3.1.37
2-oxoglutarate
-
Homo sapiens
2.3.1.37
2-oxoglutarate
-
Oryctolagus cuniculus
2.3.1.37
2-oxoglutarate
-
Propionibacterium freudenreichii subsp. shermanii
2.3.1.37
2-oxoglutarate
-
Rattus norvegicus
2.3.1.37
2-oxoglutarate
-
Rhodobacter sphaeroides
2.3.1.37
2-oxoglutarate
-
Rhodospirillum rubrum
2.3.1.37
2-oxoglutarate
-
Saccharomyces cerevisiae
2.3.1.37
2-oxoglutarate
-
Spinacia oleracea
2.3.1.37
aminomalonate
-
Gallus gallus
2.3.1.37
aminomalonate
-
Rhodobacter sphaeroides
2.3.1.37
Aminomethylphosphonate
-
Cavia porcellus
2.3.1.37
Aminomethylphosphonate
-
Gallus gallus
2.3.1.37
Aminomethylphosphonate
-
Homo sapiens
2.3.1.37
Aminomethylphosphonate
-
Oryctolagus cuniculus
2.3.1.37
Aminomethylphosphonate
-
Propionibacterium freudenreichii subsp. shermanii
2.3.1.37
Aminomethylphosphonate
-
Rattus norvegicus
2.3.1.37
Aminomethylphosphonate
-
Rhodospirillum rubrum
2.3.1.37
Aminomethylphosphonate
-
Saccharomyces cerevisiae
2.3.1.37
Aminomethylphosphonate
-
Spinacia oleracea
2.3.1.37
Aminomethylphosphonate
-
Rhodobacter sphaeroides
2.3.1.37
beta-Alanine
-
Gallus gallus
2.3.1.37
beta-Alanine
-
Rhodobacter sphaeroides
2.3.1.37
Borohydride
in presence of pyridoxal 5'-phosphate
Rhodobacter sphaeroides
2.3.1.37
Cu2+
-
Rhodobacter sphaeroides
2.3.1.37
Cu2+
-
Rhodospirillum rubrum
2.3.1.37
cyanide
-
Gallus gallus
2.3.1.37
Diethyl aminomalonate
-
Gallus gallus
2.3.1.37
Diethyl aminomalonate
-
Rhodobacter sphaeroides
2.3.1.37
ethanolamine
-
Gallus gallus
2.3.1.37
ethanolamine
-
Rhodobacter sphaeroides
2.3.1.37
ethanolamine
-
Rhodospirillum rubrum
2.3.1.37
Fe2+
-
Rhodobacter sphaeroides
2.3.1.37
Fe3+
-
Oryctolagus cuniculus
2.3.1.37
Fe3+
no inhibition
Rhodobacter sphaeroides
2.3.1.37
ferroheme
-
Cavia porcellus
2.3.1.37
ferroheme
-
Gallus gallus
2.3.1.37
ferroheme
-
Homo sapiens
2.3.1.37
ferroheme
-
Oryctolagus cuniculus
2.3.1.37
ferroheme
-
Propionibacterium freudenreichii subsp. shermanii
2.3.1.37
ferroheme
-
Rattus norvegicus
2.3.1.37
ferroheme
-
Rhodobacter sphaeroides
2.3.1.37
ferroheme
-
Rhodospirillum rubrum
2.3.1.37
ferroheme
-
Saccharomyces cerevisiae
2.3.1.37
ferroheme
-
Spinacia oleracea
2.3.1.37
glutathione
-
Oryctolagus cuniculus
2.3.1.37
hemin
-
Homo sapiens
2.3.1.37
hemin
-
Oryctolagus cuniculus
2.3.1.37
hemin
-
Propionibacterium freudenreichii subsp. shermanii
2.3.1.37
hemin
-
Rattus norvegicus
2.3.1.37
hemin
-
Rhodospirillum rubrum
2.3.1.37
hemin
-
Spinacia oleracea
2.3.1.37
hemin
-
Gallus gallus
2.3.1.37
hemin
-
Saccharomyces cerevisiae
2.3.1.37
hemin
-
Cavia porcellus
2.3.1.37
hemin
-
Rhodobacter sphaeroides
2.3.1.37
hemoglobin
-
Cavia porcellus
2.3.1.37
hemoglobin
-
Gallus gallus
2.3.1.37
hemoglobin
-
Homo sapiens
2.3.1.37
hemoglobin
-
Oryctolagus cuniculus
2.3.1.37
hemoglobin
-
Propionibacterium freudenreichii subsp. shermanii
2.3.1.37
hemoglobin
-
Rattus norvegicus
2.3.1.37
hemoglobin
-
Rhodobacter sphaeroides
2.3.1.37
hemoglobin
-
Rhodospirillum rubrum
2.3.1.37
hemoglobin
-
Saccharomyces cerevisiae
2.3.1.37
hemoglobin
-
Spinacia oleracea
2.3.1.37
iodoacetamide
-
Rhodobacter sphaeroides
2.3.1.37
Isobutylamine
-
Gallus gallus
2.3.1.37
Isobutylamine
-
Rhodobacter sphaeroides
2.3.1.37
L-alanine
-
Gallus gallus
2.3.1.37
L-alanine
-
Rhodobacter sphaeroides
2.3.1.37
L-cysteine
-
Gallus gallus
2.3.1.37
L-Penicillamine
-
Gallus gallus
2.3.1.37
L-threonine
-
Gallus gallus
2.3.1.37
L-threonine
-
Rhodobacter sphaeroides
2.3.1.37
metalloporphyrins
containing Co2+, Zn2+ or Mg2+
Cavia porcellus
2.3.1.37
metalloporphyrins
containing Co2+, Zn2+ or Mg2+
Gallus gallus
2.3.1.37
metalloporphyrins
containing Co2+, Zn2+ or Mg2+
Homo sapiens
2.3.1.37
metalloporphyrins
containing Co2+, Zn2+ or Mg2+
Oryctolagus cuniculus
2.3.1.37
metalloporphyrins
containing Co2+, Zn2+ or Mg2+
Propionibacterium freudenreichii subsp. shermanii
2.3.1.37
metalloporphyrins
containing Co2+, Zn2+ or Mg2+
Rattus norvegicus
2.3.1.37
metalloporphyrins
containing Co2+, Zn2+ or Mg2+
Rhodobacter sphaeroides
2.3.1.37
metalloporphyrins
containing Co2+, Zn2+ or Mg2+
Rhodospirillum rubrum
2.3.1.37
metalloporphyrins
containing Co2+, Zn2+ or Mg2+
Saccharomyces cerevisiae
2.3.1.37
metalloporphyrins
containing Co2+, Zn2+ or Mg2+
Spinacia oleracea
2.3.1.37
myoglobin
-
Cavia porcellus
2.3.1.37
myoglobin
-
Gallus gallus
2.3.1.37
myoglobin
-
Homo sapiens
2.3.1.37
myoglobin
-
Oryctolagus cuniculus
2.3.1.37
myoglobin
-
Propionibacterium freudenreichii subsp. shermanii
2.3.1.37
myoglobin
-
Rattus norvegicus
2.3.1.37
myoglobin
-
Rhodobacter sphaeroides
2.3.1.37
myoglobin
-
Rhodospirillum rubrum
2.3.1.37
myoglobin
-
Saccharomyces cerevisiae
2.3.1.37
myoglobin
-
Spinacia oleracea
2.3.1.37
p-mercuribenzoate
-
Gallus gallus
2.3.1.37
p-mercuribenzoate
-
Rhodobacter sphaeroides
2.3.1.37
pyruvate
-
Cavia porcellus
2.3.1.37
pyruvate
-
Gallus gallus
2.3.1.37
pyruvate
-
Homo sapiens
2.3.1.37
pyruvate
-
Oryctolagus cuniculus
2.3.1.37
pyruvate
-
Propionibacterium freudenreichii subsp. shermanii
2.3.1.37
pyruvate
-
Rattus norvegicus
2.3.1.37
pyruvate
-
Rhodobacter sphaeroides
2.3.1.37
pyruvate
-
Rhodospirillum rubrum
2.3.1.37
pyruvate
-
Saccharomyces cerevisiae
2.3.1.37
pyruvate
-
Spinacia oleracea
KM Value [mM]
EC Number
KM Value [mM]
KM Value Maximum [mM]
Substrate
Commentary
Organism
Structure
2.3.1.37
additional information
-
additional information
-
Cavia porcellus
2.3.1.37
additional information
-
additional information
overview
Gallus gallus
2.3.1.37
additional information
-
additional information
-
Homo sapiens
2.3.1.37
additional information
-
additional information
overview
Oryctolagus cuniculus
2.3.1.37
additional information
-
additional information
-
Propionibacterium freudenreichii subsp. shermanii
2.3.1.37
additional information
-
additional information
overview
Rattus norvegicus
2.3.1.37
additional information
-
additional information
overview
Rhodobacter sphaeroides
2.3.1.37
additional information
-
additional information
-
Saccharomyces cerevisiae
2.3.1.37
additional information
-
additional information
-
Spinacia oleracea
Localization
EC Number
Localization
Commentary
Organism
GeneOntology No.
Textmining
2.3.1.37
microsome
-
Cavia porcellus
-
-
2.3.1.37
microsome
-
Homo sapiens
-
-
2.3.1.37
microsome
-
Oryctolagus cuniculus
-
-
2.3.1.37
microsome
-
Rattus norvegicus
-
-
2.3.1.37
mitochondrion
-
Oryctolagus cuniculus
5739
-
2.3.1.37
mitochondrion
-
Cavia porcellus
5739
-
2.3.1.37
mitochondrion
-
Gallus gallus
5739
-
2.3.1.37
mitochondrion
-
Rattus norvegicus
5739
-
2.3.1.37
mitochondrion
-
Homo sapiens
5739
-
2.3.1.37
additional information
synthesized in microsomes and then migrates to the mitochondria
Cavia porcellus
-
-
2.3.1.37
additional information
synthesized in microsomes and then migrates to the mitochondria
Homo sapiens
-
-
2.3.1.37
additional information
synthesized in microsomes and then migrates to the mitochondria
Oryctolagus cuniculus
-
-
2.3.1.37
additional information
synthesized in microsomes and then migrates to the mitochondria
Rattus norvegicus
-
-
Molecular Weight [Da]
EC Number
Molecular Weight [Da]
Molecular Weight Maximum [Da]
Commentary
Organism
2.3.1.37
additional information
-
-
Gallus gallus
2.3.1.37
additional information
-
-
Homo sapiens
2.3.1.37
additional information
-
-
Rattus norvegicus
2.3.1.37
additional information
-
-
Rhodobacter sphaeroides
2.3.1.37
200000
-
gel filtration
Oryctolagus cuniculus
Natural Substrates/ Products (Substrates)
EC Number
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
2.3.1.37
succinyl-CoA + glycine
Gallus gallus
key enzyme in tetrapyrrole biosynthesis
5-aminolevulinate + CoA + CO2
-
Gallus gallus
?
2.3.1.37
succinyl-CoA + glycine
Cavia porcellus
key enzyme in tetrapyrrole biosynthesis
5-aminolevulinate + CoA + CO2
-
-
?
2.3.1.37
succinyl-CoA + glycine
Homo sapiens
key enzyme in tetrapyrrole biosynthesis
5-aminolevulinate + CoA + CO2
-
Homo sapiens
?
2.3.1.37
succinyl-CoA + glycine
Rattus norvegicus
key enzyme in tetrapyrrole biosynthesis
5-aminolevulinate + CoA + CO2
-
Rattus norvegicus
?
2.3.1.37
succinyl-CoA + glycine
Saccharomyces cerevisiae
key enzyme in tetrapyrrole biosynthesis
5-aminolevulinate + CoA + CO2
-
-
?
2.3.1.37
succinyl-CoA + glycine
Oryctolagus cuniculus
key enzyme in tetrapyrrole biosynthesis
5-aminolevulinate + CoA + CO2
-
-
?
2.3.1.37
succinyl-CoA + glycine
Rhodobacter sphaeroides
key enzyme in tetrapyrrole biosynthesis
5-aminolevulinate + CoA + CO2
-
Rhodobacter sphaeroides
?
2.3.1.37
succinyl-CoA + glycine
Spinacia oleracea
key enzyme in tetrapyrrole biosynthesis
5-aminolevulinate + CoA + CO2
-
-
?
2.3.1.37
succinyl-CoA + glycine
Propionibacterium freudenreichii subsp. shermanii
key enzyme in tetrapyrrole biosynthesis
5-aminolevulinate + CoA + CO2
-
-
?
2.3.1.37
succinyl-CoA + glycine
Rhodospirillum rubrum
key enzyme in tetrapyrrole biosynthesis
5-aminolevulinate + CoA + CO2
-
-
?
2.3.1.37
succinyl-CoA + glycine
Novispirillum itersonii
key enzyme in tetrapyrrole biosynthesis
5-aminolevulinate + CoA + CO2
-
-
?
2.3.1.37
succinyl-CoA + glycine
Gallus gallus
rate-limiting enzyme of heme biosynthesis
5-aminolevulinate + CoA + CO2
-
Gallus gallus
?
2.3.1.37
succinyl-CoA + glycine
Cavia porcellus
rate-limiting enzyme of heme biosynthesis
5-aminolevulinate + CoA + CO2
-
-
?
2.3.1.37
succinyl-CoA + glycine
Homo sapiens
rate-limiting enzyme of heme biosynthesis
5-aminolevulinate + CoA + CO2
-
Homo sapiens
?
2.3.1.37
succinyl-CoA + glycine
Rattus norvegicus
rate-limiting enzyme of heme biosynthesis
5-aminolevulinate + CoA + CO2
-
Rattus norvegicus
?
2.3.1.37
succinyl-CoA + glycine
Saccharomyces cerevisiae
rate-limiting enzyme of heme biosynthesis
5-aminolevulinate + CoA + CO2
-
-
?
2.3.1.37
succinyl-CoA + glycine
Oryctolagus cuniculus
rate-limiting enzyme of heme biosynthesis
5-aminolevulinate + CoA + CO2
-
-
?
2.3.1.37
succinyl-CoA + glycine
Rhodobacter sphaeroides
rate-limiting enzyme of heme biosynthesis
5-aminolevulinate + CoA + CO2
-
Rhodobacter sphaeroides
?
2.3.1.37
succinyl-CoA + glycine
Spinacia oleracea
rate-limiting enzyme of heme biosynthesis
5-aminolevulinate + CoA + CO2
-
-
?
2.3.1.37
succinyl-CoA + glycine
Propionibacterium freudenreichii subsp. shermanii
rate-limiting enzyme of heme biosynthesis
5-aminolevulinate + CoA + CO2
-
-
?
2.3.1.37
succinyl-CoA + glycine
Rhodospirillum rubrum
rate-limiting enzyme of heme biosynthesis
5-aminolevulinate + CoA + CO2
-
-
?
Organism
EC Number
Organism
Primary Accession No. (UniProt)
Commentary
Textmining
2.3.1.37
Cavia porcellus
-
-
-
2.3.1.37
Gallus gallus
-
-
-
2.3.1.37
Homo sapiens
-
-
-
2.3.1.37
no activity in Chromatium sp.
-
-
-
2.3.1.37
Novispirillum itersonii
-
-
-
2.3.1.37
Oryctolagus cuniculus
-
-
-
2.3.1.37
Propionibacterium freudenreichii subsp. shermanii
-
-
-
2.3.1.37
Rattus norvegicus
-
-
-
2.3.1.37
Rhodobacter sphaeroides
-
enzyme exists in an inactive or low activity form which can under certain conditions become activated, spontaneous activation in presence of oxygen or an oxidizing agent shows a pH dependence with an optimum at about pH 7.0, assisted by 2-mercaptoethanol
-
2.3.1.37
Rhodospirillum rubrum
-
-
-
2.3.1.37
Saccharomyces cerevisiae
-
-
-
2.3.1.37
Spinacia oleracea
-
-
-
Purification (Commentary)
EC Number
Commentary
Organism
2.3.1.37
-
Oryctolagus cuniculus
2.3.1.37
-
Rattus norvegicus
2.3.1.37
-
Rhodobacter sphaeroides
Reaction
EC Number
Reaction
Commentary
Organism
2.3.1.37
succinyl-CoA + glycine = 5-aminolevulinate + CoA + CO2
mechanism
Cavia porcellus
2.3.1.37
succinyl-CoA + glycine = 5-aminolevulinate + CoA + CO2
mechanism
Oryctolagus cuniculus
2.3.1.37
succinyl-CoA + glycine = 5-aminolevulinate + CoA + CO2
mechanism
Propionibacterium freudenreichii subsp. shermanii
2.3.1.37
succinyl-CoA + glycine = 5-aminolevulinate + CoA + CO2
mechanism
Rhodospirillum rubrum
2.3.1.37
succinyl-CoA + glycine = 5-aminolevulinate + CoA + CO2
mechanism
Spinacia oleracea
2.3.1.37
succinyl-CoA + glycine = 5-aminolevulinate + CoA + CO2
mechanism
Rhodobacter sphaeroides
2.3.1.37
succinyl-CoA + glycine = 5-aminolevulinate + CoA + CO2
mechanism
Gallus gallus
2.3.1.37
succinyl-CoA + glycine = 5-aminolevulinate + CoA + CO2
mechanism
Homo sapiens
2.3.1.37
succinyl-CoA + glycine = 5-aminolevulinate + CoA + CO2
mechanism
Rattus norvegicus
2.3.1.37
succinyl-CoA + glycine = 5-aminolevulinate + CoA + CO2
mechanism
Saccharomyces cerevisiae
Source Tissue
EC Number
Source Tissue
Commentary
Organism
Textmining
2.3.1.37
erythrocyte
-
Gallus gallus
-
2.3.1.37
erythrocyte
-
Homo sapiens
-
2.3.1.37
harderian gland
-
Rattus norvegicus
-
2.3.1.37
liver
-
Oryctolagus cuniculus
-
2.3.1.37
liver
-
Cavia porcellus
-
2.3.1.37
liver
-
Gallus gallus
-
2.3.1.37
liver
-
Homo sapiens
-
2.3.1.37
liver
-
Rattus norvegicus
-
2.3.1.37
reticulocyte
-
Oryctolagus cuniculus
-
2.3.1.37
reticulocyte
-
Rattus norvegicus
-
Specific Activity [micromol/min/mg]
EC Number
Specific Activity Minimum [Ámol/min/mg]
Specific Activity Maximum [Ámol/min/mg]
Commentary
Organism
2.3.1.37
additional information
-
various tissues, overview
Gallus gallus
2.3.1.37
additional information
-
various tissues, overview
Homo sapiens
2.3.1.37
additional information
-
various tissues, overview
Novispirillum itersonii
2.3.1.37
additional information
-
various tissues, overview
Oryctolagus cuniculus
2.3.1.37
additional information
-
various tissues, overview
Propionibacterium freudenreichii subsp. shermanii
2.3.1.37
additional information
-
various tissues, overview
Rattus norvegicus
2.3.1.37
additional information
-
various tissues, overview
Rhodobacter sphaeroides
2.3.1.37
additional information
-
various tissues, overview
Rhodospirillum rubrum
Substrates and Products (Substrate)
EC Number
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
2.3.1.37
acetyl-CoA + glycine
at 2% the rate of the reaction with succinyl-CoA
486820
Gallus gallus
?
-
-
-
?
2.3.1.37
acetyl-CoA + glycine
at 2% the rate of the reaction with succinyl-CoA
486820
Cavia porcellus
?
-
-
-
?
2.3.1.37
acetyl-CoA + glycine
at 2% the rate of the reaction with succinyl-CoA
486820
Homo sapiens
?
-
-
-
?
2.3.1.37
acetyl-CoA + glycine
at 2% the rate of the reaction with succinyl-CoA
486820
Rattus norvegicus
?
-
-
-
?
2.3.1.37
acetyl-CoA + glycine
at 2% the rate of the reaction with succinyl-CoA
486820
Saccharomyces cerevisiae
?
-
-
-
?
2.3.1.37
acetyl-CoA + glycine
at 2% the rate of the reaction with succinyl-CoA
486820
Oryctolagus cuniculus
?
-
-
-
?
2.3.1.37
acetyl-CoA + glycine
at 2% the rate of the reaction with succinyl-CoA
486820
Rhodobacter sphaeroides
?
-
-
-
?
2.3.1.37
acetyl-CoA + glycine
at 2% the rate of the reaction with succinyl-CoA
486820
Spinacia oleracea
?
-
-
-
?
2.3.1.37
acetyl-CoA + glycine
at 2% the rate of the reaction with succinyl-CoA
486820
Propionibacterium freudenreichii subsp. shermanii
?
-
-
-
?
2.3.1.37
acetyl-CoA + glycine
at 2% the rate of the reaction with succinyl-CoA
486820
Rhodospirillum rubrum
?
-
-
-
?
2.3.1.37
alpha-glutamyl-CoA + glycine
at 9% the rate of the reaction with succinyl-CoA
486820
Gallus gallus
6-amino-5-oxohexanoate + CoA + CO2
-
-
-
?
2.3.1.37
alpha-glutamyl-CoA + glycine
at 9% the rate of the reaction with succinyl-CoA
486820
Cavia porcellus
6-amino-5-oxohexanoate + CoA + CO2
-
-
-
?
2.3.1.37
alpha-glutamyl-CoA + glycine
at 9% the rate of the reaction with succinyl-CoA
486820
Homo sapiens
6-amino-5-oxohexanoate + CoA + CO2
-
-
-
?
2.3.1.37
alpha-glutamyl-CoA + glycine
at 9% the rate of the reaction with succinyl-CoA
486820
Rattus norvegicus
6-amino-5-oxohexanoate + CoA + CO2
-
-
-
?
2.3.1.37
alpha-glutamyl-CoA + glycine
at 9% the rate of the reaction with succinyl-CoA
486820
Saccharomyces cerevisiae
6-amino-5-oxohexanoate + CoA + CO2
-
-
-
?
2.3.1.37
alpha-glutamyl-CoA + glycine
at 9% the rate of the reaction with succinyl-CoA
486820
Oryctolagus cuniculus
6-amino-5-oxohexanoate + CoA + CO2
-
-
-
?
2.3.1.37
alpha-glutamyl-CoA + glycine
at 9% the rate of the reaction with succinyl-CoA
486820
Rhodobacter sphaeroides
6-amino-5-oxohexanoate + CoA + CO2
-
-
-
?
2.3.1.37
alpha-glutamyl-CoA + glycine
at 9% the rate of the reaction with succinyl-CoA
486820
Spinacia oleracea
6-amino-5-oxohexanoate + CoA + CO2
-
-
-
?
2.3.1.37
alpha-glutamyl-CoA + glycine
at 9% the rate of the reaction with succinyl-CoA
486820
Propionibacterium freudenreichii subsp. shermanii
6-amino-5-oxohexanoate + CoA + CO2
-
-
-
?
2.3.1.37
alpha-glutamyl-CoA + glycine
at 9% the rate of the reaction with succinyl-CoA
486820
Rhodospirillum rubrum
6-amino-5-oxohexanoate + CoA + CO2
-
-
-
?
2.3.1.37
succinyl-CoA + glycine
-
486820
Novispirillum itersonii
5-aminolevulinate + CoA + CO2
-
486820
Novispirillum itersonii
ir
2.3.1.37
succinyl-CoA + glycine
absolute requirement for glycine
486820
Gallus gallus
5-aminolevulinate + CoA + CO2
-
486820
Gallus gallus
ir
2.3.1.37
succinyl-CoA + glycine
absolute requirement for glycine
486820
Cavia porcellus
5-aminolevulinate + CoA + CO2
-
486820
Cavia porcellus
ir
2.3.1.37
succinyl-CoA + glycine
absolute requirement for glycine
486820
Homo sapiens
5-aminolevulinate + CoA + CO2
-
486820
Homo sapiens
ir
2.3.1.37
succinyl-CoA + glycine
absolute requirement for glycine
486820
Rattus norvegicus
5-aminolevulinate + CoA + CO2
-
486820
Rattus norvegicus
ir
2.3.1.37
succinyl-CoA + glycine
absolute requirement for glycine
486820
Saccharomyces cerevisiae
5-aminolevulinate + CoA + CO2
-
486820
Saccharomyces cerevisiae
ir
2.3.1.37
succinyl-CoA + glycine
absolute requirement for glycine
486820
Oryctolagus cuniculus
5-aminolevulinate + CoA + CO2
-
486820
Oryctolagus cuniculus
ir
2.3.1.37
succinyl-CoA + glycine
absolute requirement for glycine
486820
Rhodobacter sphaeroides
5-aminolevulinate + CoA + CO2
-
486820
Rhodobacter sphaeroides
ir
2.3.1.37
succinyl-CoA + glycine
absolute requirement for glycine
486820
Spinacia oleracea
5-aminolevulinate + CoA + CO2
-
486820
Spinacia oleracea
ir
2.3.1.37
succinyl-CoA + glycine
absolute requirement for glycine
486820
Propionibacterium freudenreichii subsp. shermanii
5-aminolevulinate + CoA + CO2
-
486820
Propionibacterium freudenreichii subsp. shermanii
ir
2.3.1.37
succinyl-CoA + glycine
absolute requirement for glycine
486820
Rhodospirillum rubrum
5-aminolevulinate + CoA + CO2
-
486820
Rhodospirillum rubrum
ir
2.3.1.37
succinyl-CoA + glycine
key enzyme in tetrapyrrole biosynthesis
486820
Gallus gallus
5-aminolevulinate + CoA + CO2
-
486820
Gallus gallus
?
2.3.1.37
succinyl-CoA + glycine
key enzyme in tetrapyrrole biosynthesis
486820
Cavia porcellus
5-aminolevulinate + CoA + CO2
-
-
-
?
2.3.1.37
succinyl-CoA + glycine
key enzyme in tetrapyrrole biosynthesis
486820
Homo sapiens
5-aminolevulinate + CoA + CO2
-
486820
Homo sapiens
?
2.3.1.37
succinyl-CoA + glycine
key enzyme in tetrapyrrole biosynthesis
486820
Rattus norvegicus
5-aminolevulinate + CoA + CO2
-
486820
Rattus norvegicus
?
2.3.1.37
succinyl-CoA + glycine
key enzyme in tetrapyrrole biosynthesis
486820
Saccharomyces cerevisiae
5-aminolevulinate + CoA + CO2
-
-
-
?
2.3.1.37
succinyl-CoA + glycine
key enzyme in tetrapyrrole biosynthesis
486820
Oryctolagus cuniculus
5-aminolevulinate + CoA + CO2
-
-
-
?
2.3.1.37
succinyl-CoA + glycine
key enzyme in tetrapyrrole biosynthesis
486820
Rhodobacter sphaeroides
5-aminolevulinate + CoA + CO2
-
486820
Rhodobacter sphaeroides
?
2.3.1.37
succinyl-CoA + glycine
key enzyme in tetrapyrrole biosynthesis
486820
Spinacia oleracea
5-aminolevulinate + CoA + CO2
-
-
-
?
2.3.1.37
succinyl-CoA + glycine
key enzyme in tetrapyrrole biosynthesis
486820
Propionibacterium freudenreichii subsp. shermanii
5-aminolevulinate + CoA + CO2
-
-
-
?
2.3.1.37
succinyl-CoA + glycine
key enzyme in tetrapyrrole biosynthesis
486820
Rhodospirillum rubrum
5-aminolevulinate + CoA + CO2
-
-
-
?
2.3.1.37
succinyl-CoA + glycine
key enzyme in tetrapyrrole biosynthesis
486820
Novispirillum itersonii
5-aminolevulinate + CoA + CO2
-
-
-
?
2.3.1.37
succinyl-CoA + glycine
rate-limiting enzyme of heme biosynthesis
486820
Gallus gallus
5-aminolevulinate + CoA + CO2
-
486820
Gallus gallus
?
2.3.1.37
succinyl-CoA + glycine
rate-limiting enzyme of heme biosynthesis
486820
Cavia porcellus
5-aminolevulinate + CoA + CO2
-
-
-
?
2.3.1.37
succinyl-CoA + glycine
rate-limiting enzyme of heme biosynthesis
486820
Homo sapiens
5-aminolevulinate + CoA + CO2
-
486820
Homo sapiens
?
2.3.1.37
succinyl-CoA + glycine
rate-limiting enzyme of heme biosynthesis
486820
Rattus norvegicus
5-aminolevulinate + CoA + CO2
-
486820
Rattus norvegicus
?
2.3.1.37
succinyl-CoA + glycine
rate-limiting enzyme of heme biosynthesis
486820
Saccharomyces cerevisiae
5-aminolevulinate + CoA + CO2
-
-
-
?
2.3.1.37
succinyl-CoA + glycine
rate-limiting enzyme of heme biosynthesis
486820
Oryctolagus cuniculus
5-aminolevulinate + CoA + CO2
-
-
-
?
2.3.1.37
succinyl-CoA + glycine
rate-limiting enzyme of heme biosynthesis
486820
Rhodobacter sphaeroides
5-aminolevulinate + CoA + CO2
-
486820
Rhodobacter sphaeroides
?
2.3.1.37
succinyl-CoA + glycine
rate-limiting enzyme of heme biosynthesis
486820
Spinacia oleracea
5-aminolevulinate + CoA + CO2
-
-
-
?
2.3.1.37
succinyl-CoA + glycine
rate-limiting enzyme of heme biosynthesis
486820
Propionibacterium freudenreichii subsp. shermanii
5-aminolevulinate + CoA + CO2
-
-
-
?
2.3.1.37
succinyl-CoA + glycine
rate-limiting enzyme of heme biosynthesis
486820
Rhodospirillum rubrum
5-aminolevulinate + CoA + CO2
-
-
-
?
2.3.1.37
succinyl-CoA-monomethyl ester + glycine
at 80% the rate of the reaction with succinyl-CoA
486820
Gallus gallus
5-aminolevulinic acid methyl ester + CoA + CO2
-
-
-
-
2.3.1.37
succinyl-CoA-monomethyl ester + glycine
at 80% the rate of the reaction with succinyl-CoA
486820
Cavia porcellus
5-aminolevulinic acid methyl ester + CoA + CO2
-
-
-
-
2.3.1.37
succinyl-CoA-monomethyl ester + glycine
at 80% the rate of the reaction with succinyl-CoA
486820
Homo sapiens
5-aminolevulinic acid methyl ester + CoA + CO2
-
-
-
-
2.3.1.37
succinyl-CoA-monomethyl ester + glycine
at 80% the rate of the reaction with succinyl-CoA
486820
Rattus norvegicus
5-aminolevulinic acid methyl ester + CoA + CO2
-
-
-
-
2.3.1.37
succinyl-CoA-monomethyl ester + glycine
at 80% the rate of the reaction with succinyl-CoA
486820
Saccharomyces cerevisiae
5-aminolevulinic acid methyl ester + CoA + CO2
-
-
-
-
2.3.1.37
succinyl-CoA-monomethyl ester + glycine
at 80% the rate of the reaction with succinyl-CoA
486820
Oryctolagus cuniculus
5-aminolevulinic acid methyl ester + CoA + CO2
-
-
-
-
2.3.1.37
succinyl-CoA-monomethyl ester + glycine
at 80% the rate of the reaction with succinyl-CoA
486820
Rhodobacter sphaeroides
5-aminolevulinic acid methyl ester + CoA + CO2
-
-
-
-
2.3.1.37
succinyl-CoA-monomethyl ester + glycine
at 80% the rate of the reaction with succinyl-CoA
486820
Spinacia oleracea
5-aminolevulinic acid methyl ester + CoA + CO2
-
-
-
-
2.3.1.37
succinyl-CoA-monomethyl ester + glycine
at 80% the rate of the reaction with succinyl-CoA
486820
Propionibacterium freudenreichii subsp. shermanii
5-aminolevulinic acid methyl ester + CoA + CO2
-
-
-
-
2.3.1.37
succinyl-CoA-monomethyl ester + glycine
at 80% the rate of the reaction with succinyl-CoA
486820
Rhodospirillum rubrum
5-aminolevulinic acid methyl ester + CoA + CO2
-
-
-
-
Temperature Stability [░C]
EC Number
Temperature Stability Minimum [░C]
Temperature Stability Maximum [░C]
Commentary
Organism
2.3.1.37
additional information
-
-
Rattus norvegicus
2.3.1.37
additional information
-
temperature insensitive
Rhodobacter sphaeroides
Cofactor
EC Number
Cofactor
Commentary
Organism
Structure
2.3.1.37
pyridoxal 5'-phosphate
-
Novispirillum itersonii
2.3.1.37
pyridoxal 5'-phosphate
-
Propionibacterium freudenreichii subsp. shermanii
2.3.1.37
pyridoxal 5'-phosphate
-
Rhodospirillum rubrum
2.3.1.37
pyridoxal 5'-phosphate
-
Spinacia oleracea
2.3.1.37
pyridoxal 5'-phosphate
bound to the enzyme through a Schiff base linkage
Rhodobacter sphaeroides
2.3.1.37
pyridoxal 5'-phosphate
-
Oryctolagus cuniculus
2.3.1.37
pyridoxal 5'-phosphate
-
Gallus gallus
2.3.1.37
pyridoxal 5'-phosphate
-
Cavia porcellus
2.3.1.37
pyridoxal 5'-phosphate
-
Rattus norvegicus
2.3.1.37
pyridoxal 5'-phosphate
-
Saccharomyces cerevisiae
2.3.1.37
pyridoxal 5'-phosphate
-
Homo sapiens
Activating Compound (protein specific)
EC Number
Activating Compound
Commentary
Organism
Structure
2.3.1.37
2-allyl-2-isopropylacetamide
strong induction of enzyme in liver
Cavia porcellus
2.3.1.37
2-allyl-2-isopropylacetamide
strong induction of enzyme in liver
Gallus gallus
2.3.1.37
2-allyl-2-isopropylacetamide
strong induction of enzyme in liver
Rattus norvegicus
Cofactor (protein specific)
EC Number
Cofactor
Commentary
Organism
Structure
2.3.1.37
pyridoxal 5'-phosphate
-
Novispirillum itersonii
2.3.1.37
pyridoxal 5'-phosphate
-
Propionibacterium freudenreichii subsp. shermanii
2.3.1.37
pyridoxal 5'-phosphate
-
Rhodospirillum rubrum
2.3.1.37
pyridoxal 5'-phosphate
-
Spinacia oleracea
2.3.1.37
pyridoxal 5'-phosphate
bound to the enzyme through a Schiff base linkage
Rhodobacter sphaeroides
2.3.1.37
pyridoxal 5'-phosphate
-
Oryctolagus cuniculus
2.3.1.37
pyridoxal 5'-phosphate
-
Gallus gallus
2.3.1.37
pyridoxal 5'-phosphate
-
Cavia porcellus
2.3.1.37
pyridoxal 5'-phosphate
-
Rattus norvegicus
2.3.1.37
pyridoxal 5'-phosphate
-
Saccharomyces cerevisiae
2.3.1.37
pyridoxal 5'-phosphate
-
Homo sapiens
Inhibitors (protein specific)
EC Number
Inhibitors
Commentary
Organism
Structure
2.3.1.37
2-hydroxyethyldisulfide
-
Rhodobacter sphaeroides
2.3.1.37
2-mercaptoethanol
-
Oryctolagus cuniculus
2.3.1.37
2-oxoglutarate
-
Cavia porcellus
2.3.1.37
2-oxoglutarate
-
Gallus gallus
2.3.1.37
2-oxoglutarate
-
Homo sapiens
2.3.1.37
2-oxoglutarate
-
Oryctolagus cuniculus
2.3.1.37
2-oxoglutarate
-
Propionibacterium freudenreichii subsp. shermanii
2.3.1.37
2-oxoglutarate
-
Rattus norvegicus
2.3.1.37
2-oxoglutarate
-
Rhodobacter sphaeroides
2.3.1.37
2-oxoglutarate
-
Rhodospirillum rubrum
2.3.1.37
2-oxoglutarate
-
Saccharomyces cerevisiae
2.3.1.37
2-oxoglutarate
-
Spinacia oleracea
2.3.1.37
aminomalonate
-
Gallus gallus
2.3.1.37
aminomalonate
-
Rhodobacter sphaeroides
2.3.1.37
Aminomethylphosphonate
-
Cavia porcellus
2.3.1.37
Aminomethylphosphonate
-
Gallus gallus
2.3.1.37
Aminomethylphosphonate
-
Homo sapiens
2.3.1.37
Aminomethylphosphonate
-
Oryctolagus cuniculus
2.3.1.37
Aminomethylphosphonate
-
Propionibacterium freudenreichii subsp. shermanii
2.3.1.37
Aminomethylphosphonate
-
Rattus norvegicus
2.3.1.37
Aminomethylphosphonate
-
Rhodospirillum rubrum
2.3.1.37
Aminomethylphosphonate
-
Saccharomyces cerevisiae
2.3.1.37
Aminomethylphosphonate
-
Spinacia oleracea
2.3.1.37
Aminomethylphosphonate
-
Rhodobacter sphaeroides
2.3.1.37
beta-Alanine
-
Gallus gallus
2.3.1.37
beta-Alanine
-
Rhodobacter sphaeroides
2.3.1.37
Borohydride
in presence of pyridoxal 5'-phosphate
Rhodobacter sphaeroides
2.3.1.37
Cu2+
-
Rhodobacter sphaeroides
2.3.1.37
Cu2+
-
Rhodospirillum rubrum
2.3.1.37
cyanide
-
Gallus gallus
2.3.1.37
Diethyl aminomalonate
-
Gallus gallus
2.3.1.37
Diethyl aminomalonate
-
Rhodobacter sphaeroides
2.3.1.37
ethanolamine
-
Gallus gallus
2.3.1.37
ethanolamine
-
Rhodobacter sphaeroides
2.3.1.37
ethanolamine
-
Rhodospirillum rubrum
2.3.1.37
Fe2+
-
Rhodobacter sphaeroides
2.3.1.37
Fe3+
-
Oryctolagus cuniculus
2.3.1.37
Fe3+
no inhibition
Rhodobacter sphaeroides
2.3.1.37
ferroheme
-
Cavia porcellus
2.3.1.37
ferroheme
-
Gallus gallus
2.3.1.37
ferroheme
-
Homo sapiens
2.3.1.37
ferroheme
-
Oryctolagus cuniculus
2.3.1.37
ferroheme
-
Propionibacterium freudenreichii subsp. shermanii
2.3.1.37
ferroheme
-
Rattus norvegicus
2.3.1.37
ferroheme
-
Rhodobacter sphaeroides
2.3.1.37
ferroheme
-
Rhodospirillum rubrum
2.3.1.37
ferroheme
-
Saccharomyces cerevisiae
2.3.1.37
ferroheme
-
Spinacia oleracea
2.3.1.37
glutathione
-
Oryctolagus cuniculus
2.3.1.37
hemin
-
Homo sapiens
2.3.1.37
hemin
-
Oryctolagus cuniculus
2.3.1.37
hemin
-
Propionibacterium freudenreichii subsp. shermanii
2.3.1.37
hemin
-
Rattus norvegicus
2.3.1.37
hemin
-
Rhodospirillum rubrum
2.3.1.37
hemin
-
Spinacia oleracea
2.3.1.37
hemin
-
Gallus gallus
2.3.1.37
hemin
-
Saccharomyces cerevisiae
2.3.1.37
hemin
-
Cavia porcellus
2.3.1.37
hemin
-
Rhodobacter sphaeroides
2.3.1.37
hemoglobin
-
Cavia porcellus
2.3.1.37
hemoglobin
-
Gallus gallus
2.3.1.37
hemoglobin
-
Homo sapiens
2.3.1.37
hemoglobin
-
Oryctolagus cuniculus
2.3.1.37
hemoglobin
-
Propionibacterium freudenreichii subsp. shermanii
2.3.1.37
hemoglobin
-
Rattus norvegicus
2.3.1.37
hemoglobin
-
Rhodobacter sphaeroides
2.3.1.37
hemoglobin
-
Rhodospirillum rubrum
2.3.1.37
hemoglobin
-
Saccharomyces cerevisiae
2.3.1.37
hemoglobin
-
Spinacia oleracea
2.3.1.37
iodoacetamide
-
Rhodobacter sphaeroides
2.3.1.37
Isobutylamine
-
Gallus gallus
2.3.1.37
Isobutylamine
-
Rhodobacter sphaeroides
2.3.1.37
L-alanine
-
Gallus gallus
2.3.1.37
L-alanine
-
Rhodobacter sphaeroides
2.3.1.37
L-cysteine
-
Gallus gallus
2.3.1.37
L-Penicillamine
-
Gallus gallus
2.3.1.37
L-threonine
-
Gallus gallus
2.3.1.37
L-threonine
-
Rhodobacter sphaeroides
2.3.1.37
metalloporphyrins
containing Co2+, Zn2+ or Mg2+
Cavia porcellus
2.3.1.37
metalloporphyrins
containing Co2+, Zn2+ or Mg2+
Gallus gallus
2.3.1.37
metalloporphyrins
containing Co2+, Zn2+ or Mg2+
Homo sapiens
2.3.1.37
metalloporphyrins
containing Co2+, Zn2+ or Mg2+
Oryctolagus cuniculus
2.3.1.37
metalloporphyrins
containing Co2+, Zn2+ or Mg2+
Propionibacterium freudenreichii subsp. shermanii
2.3.1.37
metalloporphyrins
containing Co2+, Zn2+ or Mg2+
Rattus norvegicus
2.3.1.37
metalloporphyrins
containing Co2+, Zn2+ or Mg2+
Rhodobacter sphaeroides
2.3.1.37
metalloporphyrins
containing Co2+, Zn2+ or Mg2+
Rhodospirillum rubrum
2.3.1.37
metalloporphyrins
containing Co2+, Zn2+ or Mg2+
Saccharomyces cerevisiae
2.3.1.37
metalloporphyrins
containing Co2+, Zn2+ or Mg2+
Spinacia oleracea
2.3.1.37
myoglobin
-
Cavia porcellus
2.3.1.37
myoglobin
-
Gallus gallus
2.3.1.37
myoglobin
-
Homo sapiens
2.3.1.37
myoglobin
-
Oryctolagus cuniculus
2.3.1.37
myoglobin
-
Propionibacterium freudenreichii subsp. shermanii
2.3.1.37
myoglobin
-
Rattus norvegicus
2.3.1.37
myoglobin
-
Rhodobacter sphaeroides
2.3.1.37
myoglobin
-
Rhodospirillum rubrum
2.3.1.37
myoglobin
-
Saccharomyces cerevisiae
2.3.1.37
myoglobin
-
Spinacia oleracea
2.3.1.37
p-mercuribenzoate
-
Gallus gallus
2.3.1.37
p-mercuribenzoate
-
Rhodobacter sphaeroides
2.3.1.37
pyruvate
-
Cavia porcellus
2.3.1.37
pyruvate
-
Gallus gallus
2.3.1.37
pyruvate
-
Homo sapiens
2.3.1.37
pyruvate
-
Oryctolagus cuniculus
2.3.1.37
pyruvate
-
Propionibacterium freudenreichii subsp. shermanii
2.3.1.37
pyruvate
-
Rattus norvegicus
2.3.1.37
pyruvate
-
Rhodobacter sphaeroides
2.3.1.37
pyruvate
-
Rhodospirillum rubrum
2.3.1.37
pyruvate
-
Saccharomyces cerevisiae
2.3.1.37
pyruvate
-
Spinacia oleracea
KM Value [mM] (protein specific)
EC Number
KM Value [mM]
KM Value Maximum [mM]
Substrate
Commentary
Organism
Structure
2.3.1.37
additional information
-
additional information
-
Cavia porcellus
2.3.1.37
additional information
-
additional information
overview
Gallus gallus
2.3.1.37
additional information
-
additional information
-
Homo sapiens
2.3.1.37
additional information
-
additional information
overview
Oryctolagus cuniculus
2.3.1.37
additional information
-
additional information
-
Propionibacterium freudenreichii subsp. shermanii
2.3.1.37
additional information
-
additional information
overview
Rattus norvegicus
2.3.1.37
additional information
-
additional information
overview
Rhodobacter sphaeroides
2.3.1.37
additional information
-
additional information
-
Saccharomyces cerevisiae
2.3.1.37
additional information
-
additional information
-
Spinacia oleracea
Localization (protein specific)
EC Number
Localization
Commentary
Organism
GeneOntology No.
Textmining
2.3.1.37
microsome
-
Cavia porcellus
-
-
2.3.1.37
microsome
-
Homo sapiens
-
-
2.3.1.37
microsome
-
Oryctolagus cuniculus
-
-
2.3.1.37
microsome
-
Rattus norvegicus
-
-
2.3.1.37
mitochondrion
-
Oryctolagus cuniculus
5739
-
2.3.1.37
mitochondrion
-
Cavia porcellus
5739
-
2.3.1.37
mitochondrion
-
Gallus gallus
5739
-
2.3.1.37
mitochondrion
-
Rattus norvegicus
5739
-
2.3.1.37
mitochondrion
-
Homo sapiens
5739
-
2.3.1.37
additional information
synthesized in microsomes and then migrates to the mitochondria
Cavia porcellus
-
-
2.3.1.37
additional information
synthesized in microsomes and then migrates to the mitochondria
Homo sapiens
-
-
2.3.1.37
additional information
synthesized in microsomes and then migrates to the mitochondria
Oryctolagus cuniculus
-
-
2.3.1.37
additional information
synthesized in microsomes and then migrates to the mitochondria
Rattus norvegicus
-
-
Molecular Weight [Da] (protein specific)
EC Number
Molecular Weight [Da]
Molecular Weight Maximum [Da]
Commentary
Organism
2.3.1.37
additional information
-
-
Gallus gallus
2.3.1.37
additional information
-
-
Homo sapiens
2.3.1.37
additional information
-
-
Rattus norvegicus
2.3.1.37
additional information
-
-
Rhodobacter sphaeroides
2.3.1.37
200000
-
gel filtration
Oryctolagus cuniculus
Natural Substrates/ Products (Substrates) (protein specific)
EC Number
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
2.3.1.37
succinyl-CoA + glycine
Gallus gallus
key enzyme in tetrapyrrole biosynthesis
5-aminolevulinate + CoA + CO2
-
Gallus gallus
?
2.3.1.37
succinyl-CoA + glycine
Cavia porcellus
key enzyme in tetrapyrrole biosynthesis
5-aminolevulinate + CoA + CO2
-
-
?
2.3.1.37
succinyl-CoA + glycine
Homo sapiens
key enzyme in tetrapyrrole biosynthesis
5-aminolevulinate + CoA + CO2
-
Homo sapiens
?
2.3.1.37
succinyl-CoA + glycine
Rattus norvegicus
key enzyme in tetrapyrrole biosynthesis
5-aminolevulinate + CoA + CO2
-
Rattus norvegicus
?
2.3.1.37
succinyl-CoA + glycine
Saccharomyces cerevisiae
key enzyme in tetrapyrrole biosynthesis
5-aminolevulinate + CoA + CO2
-
-
?
2.3.1.37
succinyl-CoA + glycine
Oryctolagus cuniculus
key enzyme in tetrapyrrole biosynthesis
5-aminolevulinate + CoA + CO2
-
-
?
2.3.1.37
succinyl-CoA + glycine
Rhodobacter sphaeroides
key enzyme in tetrapyrrole biosynthesis
5-aminolevulinate + CoA + CO2
-
Rhodobacter sphaeroides
?
2.3.1.37
succinyl-CoA + glycine
Spinacia oleracea
key enzyme in tetrapyrrole biosynthesis
5-aminolevulinate + CoA + CO2
-
-
?
2.3.1.37
succinyl-CoA + glycine
Propionibacterium freudenreichii subsp. shermanii
key enzyme in tetrapyrrole biosynthesis
5-aminolevulinate + CoA + CO2
-
-
?
2.3.1.37
succinyl-CoA + glycine
Rhodospirillum rubrum
key enzyme in tetrapyrrole biosynthesis
5-aminolevulinate + CoA + CO2
-
-
?
2.3.1.37
succinyl-CoA + glycine
Novispirillum itersonii
key enzyme in tetrapyrrole biosynthesis
5-aminolevulinate + CoA + CO2
-
-
?
2.3.1.37
succinyl-CoA + glycine
Gallus gallus
rate-limiting enzyme of heme biosynthesis
5-aminolevulinate + CoA + CO2
-
Gallus gallus
?
2.3.1.37
succinyl-CoA + glycine
Cavia porcellus
rate-limiting enzyme of heme biosynthesis
5-aminolevulinate + CoA + CO2
-
-
?
2.3.1.37
succinyl-CoA + glycine
Homo sapiens
rate-limiting enzyme of heme biosynthesis
5-aminolevulinate + CoA + CO2
-
Homo sapiens
?
2.3.1.37
succinyl-CoA + glycine
Rattus norvegicus
rate-limiting enzyme of heme biosynthesis
5-aminolevulinate + CoA + CO2
-
Rattus norvegicus
?
2.3.1.37
succinyl-CoA + glycine
Saccharomyces cerevisiae
rate-limiting enzyme of heme biosynthesis
5-aminolevulinate + CoA + CO2
-
-
?
2.3.1.37
succinyl-CoA + glycine
Oryctolagus cuniculus
rate-limiting enzyme of heme biosynthesis
5-aminolevulinate + CoA + CO2
-
-
?
2.3.1.37
succinyl-CoA + glycine
Rhodobacter sphaeroides
rate-limiting enzyme of heme biosynthesis
5-aminolevulinate + CoA + CO2
-
Rhodobacter sphaeroides
?
2.3.1.37
succinyl-CoA + glycine
Spinacia oleracea
rate-limiting enzyme of heme biosynthesis
5-aminolevulinate + CoA + CO2
-
-
?
2.3.1.37
succinyl-CoA + glycine
Propionibacterium freudenreichii subsp. shermanii
rate-limiting enzyme of heme biosynthesis
5-aminolevulinate + CoA + CO2
-
-
?
2.3.1.37
succinyl-CoA + glycine
Rhodospirillum rubrum
rate-limiting enzyme of heme biosynthesis
5-aminolevulinate + CoA + CO2
-
-
?
Purification (Commentary) (protein specific)
EC Number
Commentary
Organism
2.3.1.37
-
Oryctolagus cuniculus
2.3.1.37
-
Rattus norvegicus
2.3.1.37
-
Rhodobacter sphaeroides
Source Tissue (protein specific)
EC Number
Source Tissue
Commentary
Organism
Textmining
2.3.1.37
erythrocyte
-
Gallus gallus
-
2.3.1.37
erythrocyte
-
Homo sapiens
-
2.3.1.37
harderian gland
-
Rattus norvegicus
-
2.3.1.37
liver
-
Oryctolagus cuniculus
-
2.3.1.37
liver
-
Cavia porcellus
-
2.3.1.37
liver
-
Gallus gallus
-
2.3.1.37
liver
-
Homo sapiens
-
2.3.1.37
liver
-
Rattus norvegicus
-
2.3.1.37
reticulocyte
-
Oryctolagus cuniculus
-
2.3.1.37
reticulocyte
-
Rattus norvegicus
-
Specific Activity [micromol/min/mg] (protein specific)
EC Number
Specific Activity Minimum [Ámol/min/mg]
Specific Activity Maximum [Ámol/min/mg]
Commentary
Organism
2.3.1.37
additional information
-
various tissues, overview
Gallus gallus
2.3.1.37
additional information
-
various tissues, overview
Homo sapiens
2.3.1.37
additional information
-
various tissues, overview
Novispirillum itersonii
2.3.1.37
additional information
-
various tissues, overview
Oryctolagus cuniculus
2.3.1.37
additional information
-
various tissues, overview
Propionibacterium freudenreichii subsp. shermanii
2.3.1.37
additional information
-
various tissues, overview
Rattus norvegicus
2.3.1.37
additional information
-
various tissues, overview
Rhodobacter sphaeroides
2.3.1.37
additional information
-
various tissues, overview
Rhodospirillum rubrum
Substrates and Products (Substrate) (protein specific)
EC Number
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
2.3.1.37
acetyl-CoA + glycine
at 2% the rate of the reaction with succinyl-CoA
486820
Gallus gallus
?
-
-
-
?
2.3.1.37
acetyl-CoA + glycine
at 2% the rate of the reaction with succinyl-CoA
486820
Cavia porcellus
?
-
-
-
?
2.3.1.37
acetyl-CoA + glycine
at 2% the rate of the reaction with succinyl-CoA
486820
Homo sapiens
?
-
-
-
?
2.3.1.37
acetyl-CoA + glycine
at 2% the rate of the reaction with succinyl-CoA
486820
Rattus norvegicus
?
-
-
-
?
2.3.1.37
acetyl-CoA + glycine
at 2% the rate of the reaction with succinyl-CoA
486820
Saccharomyces cerevisiae
?
-
-
-
?
2.3.1.37
acetyl-CoA + glycine
at 2% the rate of the reaction with succinyl-CoA
486820
Oryctolagus cuniculus
?
-
-
-
?
2.3.1.37
acetyl-CoA + glycine
at 2% the rate of the reaction with succinyl-CoA
486820
Rhodobacter sphaeroides
?
-
-
-
?
2.3.1.37
acetyl-CoA + glycine
at 2% the rate of the reaction with succinyl-CoA
486820
Spinacia oleracea
?
-
-
-
?
2.3.1.37
acetyl-CoA + glycine
at 2% the rate of the reaction with succinyl-CoA
486820
Propionibacterium freudenreichii subsp. shermanii
?
-
-
-
?
2.3.1.37
acetyl-CoA + glycine
at 2% the rate of the reaction with succinyl-CoA
486820
Rhodospirillum rubrum
?
-
-
-
?
2.3.1.37
alpha-glutamyl-CoA + glycine
at 9% the rate of the reaction with succinyl-CoA
486820
Gallus gallus
6-amino-5-oxohexanoate + CoA + CO2
-
-
-
?
2.3.1.37
alpha-glutamyl-CoA + glycine
at 9% the rate of the reaction with succinyl-CoA
486820
Cavia porcellus
6-amino-5-oxohexanoate + CoA + CO2
-
-
-
?
2.3.1.37
alpha-glutamyl-CoA + glycine
at 9% the rate of the reaction with succinyl-CoA
486820
Homo sapiens
6-amino-5-oxohexanoate + CoA + CO2
-
-
-
?
2.3.1.37
alpha-glutamyl-CoA + glycine
at 9% the rate of the reaction with succinyl-CoA
486820
Rattus norvegicus
6-amino-5-oxohexanoate + CoA + CO2
-
-
-
?
2.3.1.37
alpha-glutamyl-CoA + glycine
at 9% the rate of the reaction with succinyl-CoA
486820
Saccharomyces cerevisiae
6-amino-5-oxohexanoate + CoA + CO2
-
-
-
?
2.3.1.37
alpha-glutamyl-CoA + glycine
at 9% the rate of the reaction with succinyl-CoA
486820
Oryctolagus cuniculus
6-amino-5-oxohexanoate + CoA + CO2
-
-
-
?
2.3.1.37
alpha-glutamyl-CoA + glycine
at 9% the rate of the reaction with succinyl-CoA
486820
Rhodobacter sphaeroides
6-amino-5-oxohexanoate + CoA + CO2
-
-
-
?
2.3.1.37
alpha-glutamyl-CoA + glycine
at 9% the rate of the reaction with succinyl-CoA
486820
Spinacia oleracea
6-amino-5-oxohexanoate + CoA + CO2
-
-
-
?
2.3.1.37
alpha-glutamyl-CoA + glycine
at 9% the rate of the reaction with succinyl-CoA
486820
Propionibacterium freudenreichii subsp. shermanii
6-amino-5-oxohexanoate + CoA + CO2
-
-
-
?
2.3.1.37
alpha-glutamyl-CoA + glycine
at 9% the rate of the reaction with succinyl-CoA
486820
Rhodospirillum rubrum
6-amino-5-oxohexanoate + CoA + CO2
-
-
-
?
2.3.1.37
succinyl-CoA + glycine
-
486820
Novispirillum itersonii
5-aminolevulinate + CoA + CO2
-
486820
Novispirillum itersonii
ir
2.3.1.37
succinyl-CoA + glycine
absolute requirement for glycine
486820
Gallus gallus
5-aminolevulinate + CoA + CO2
-
486820
Gallus gallus
ir
2.3.1.37
succinyl-CoA + glycine
absolute requirement for glycine
486820
Cavia porcellus
5-aminolevulinate + CoA + CO2
-
486820
Cavia porcellus
ir
2.3.1.37
succinyl-CoA + glycine
absolute requirement for glycine
486820
Homo sapiens
5-aminolevulinate + CoA + CO2
-
486820
Homo sapiens
ir
2.3.1.37
succinyl-CoA + glycine
absolute requirement for glycine
486820
Rattus norvegicus
5-aminolevulinate + CoA + CO2
-
486820
Rattus norvegicus
ir
2.3.1.37
succinyl-CoA + glycine
absolute requirement for glycine
486820
Saccharomyces cerevisiae
5-aminolevulinate + CoA + CO2
-
486820
Saccharomyces cerevisiae
ir
2.3.1.37
succinyl-CoA + glycine
absolute requirement for glycine
486820
Oryctolagus cuniculus
5-aminolevulinate + CoA + CO2
-
486820
Oryctolagus cuniculus
ir
2.3.1.37
succinyl-CoA + glycine
absolute requirement for glycine
486820
Rhodobacter sphaeroides
5-aminolevulinate + CoA + CO2
-
486820
Rhodobacter sphaeroides
ir
2.3.1.37
succinyl-CoA + glycine
absolute requirement for glycine
486820
Spinacia oleracea
5-aminolevulinate + CoA + CO2
-
486820
Spinacia oleracea
ir
2.3.1.37
succinyl-CoA + glycine
absolute requirement for glycine
486820
Propionibacterium freudenreichii subsp. shermanii
5-aminolevulinate + CoA + CO2
-
486820
Propionibacterium freudenreichii subsp. shermanii
ir
2.3.1.37
succinyl-CoA + glycine
absolute requirement for glycine
486820
Rhodospirillum rubrum
5-aminolevulinate + CoA + CO2
-
486820
Rhodospirillum rubrum
ir
2.3.1.37
succinyl-CoA + glycine
key enzyme in tetrapyrrole biosynthesis
486820
Gallus gallus
5-aminolevulinate + CoA + CO2
-
486820
Gallus gallus
?
2.3.1.37
succinyl-CoA + glycine
key enzyme in tetrapyrrole biosynthesis
486820
Cavia porcellus
5-aminolevulinate + CoA + CO2
-
-
-
?
2.3.1.37
succinyl-CoA + glycine
key enzyme in tetrapyrrole biosynthesis
486820
Homo sapiens
5-aminolevulinate + CoA + CO2
-
486820
Homo sapiens
?
2.3.1.37
succinyl-CoA + glycine
key enzyme in tetrapyrrole biosynthesis
486820
Rattus norvegicus
5-aminolevulinate + CoA + CO2
-
486820
Rattus norvegicus
?
2.3.1.37
succinyl-CoA + glycine
key enzyme in tetrapyrrole biosynthesis
486820
Saccharomyces cerevisiae
5-aminolevulinate + CoA + CO2
-
-
-
?
2.3.1.37
succinyl-CoA + glycine
key enzyme in tetrapyrrole biosynthesis
486820
Oryctolagus cuniculus
5-aminolevulinate + CoA + CO2
-
-
-
?
2.3.1.37
succinyl-CoA + glycine
key enzyme in tetrapyrrole biosynthesis
486820
Rhodobacter sphaeroides
5-aminolevulinate + CoA + CO2
-
486820
Rhodobacter sphaeroides
?
2.3.1.37
succinyl-CoA + glycine
key enzyme in tetrapyrrole biosynthesis
486820
Spinacia oleracea
5-aminolevulinate + CoA + CO2
-
-
-
?
2.3.1.37
succinyl-CoA + glycine
key enzyme in tetrapyrrole biosynthesis
486820
Propionibacterium freudenreichii subsp. shermanii
5-aminolevulinate + CoA + CO2
-
-
-
?
2.3.1.37
succinyl-CoA + glycine
key enzyme in tetrapyrrole biosynthesis
486820
Rhodospirillum rubrum
5-aminolevulinate + CoA + CO2
-
-
-
?
2.3.1.37
succinyl-CoA + glycine
key enzyme in tetrapyrrole biosynthesis
486820
Novispirillum itersonii
5-aminolevulinate + CoA + CO2
-
-
-
?
2.3.1.37
succinyl-CoA + glycine
rate-limiting enzyme of heme biosynthesis
486820
Gallus gallus
5-aminolevulinate + CoA + CO2
-
486820
Gallus gallus
?
2.3.1.37
succinyl-CoA + glycine
rate-limiting enzyme of heme biosynthesis
486820
Cavia porcellus
5-aminolevulinate + CoA + CO2
-
-
-
?
2.3.1.37
succinyl-CoA + glycine
rate-limiting enzyme of heme biosynthesis
486820
Homo sapiens
5-aminolevulinate + CoA + CO2
-
486820
Homo sapiens
?
2.3.1.37
succinyl-CoA + glycine
rate-limiting enzyme of heme biosynthesis
486820
Rattus norvegicus
5-aminolevulinate + CoA + CO2
-
486820
Rattus norvegicus
?
2.3.1.37
succinyl-CoA + glycine
rate-limiting enzyme of heme biosynthesis
486820
Saccharomyces cerevisiae
5-aminolevulinate + CoA + CO2
-
-
-
?
2.3.1.37
succinyl-CoA + glycine
rate-limiting enzyme of heme biosynthesis
486820
Oryctolagus cuniculus
5-aminolevulinate + CoA + CO2
-
-
-
?
2.3.1.37
succinyl-CoA + glycine
rate-limiting enzyme of heme biosynthesis
486820
Rhodobacter sphaeroides
5-aminolevulinate + CoA + CO2
-
486820
Rhodobacter sphaeroides
?
2.3.1.37
succinyl-CoA + glycine
rate-limiting enzyme of heme biosynthesis
486820
Spinacia oleracea
5-aminolevulinate + CoA + CO2
-
-
-
?
2.3.1.37
succinyl-CoA + glycine
rate-limiting enzyme of heme biosynthesis
486820
Propionibacterium freudenreichii subsp. shermanii
5-aminolevulinate + CoA + CO2
-
-
-
?
2.3.1.37
succinyl-CoA + glycine
rate-limiting enzyme of heme biosynthesis
486820
Rhodospirillum rubrum
5-aminolevulinate + CoA + CO2
-
-
-
?
2.3.1.37
succinyl-CoA-monomethyl ester + glycine
at 80% the rate of the reaction with succinyl-CoA
486820
Gallus gallus
5-aminolevulinic acid methyl ester + CoA + CO2
-
-
-
-
2.3.1.37
succinyl-CoA-monomethyl ester + glycine
at 80% the rate of the reaction with succinyl-CoA
486820
Cavia porcellus
5-aminolevulinic acid methyl ester + CoA + CO2
-
-
-
-
2.3.1.37
succinyl-CoA-monomethyl ester + glycine
at 80% the rate of the reaction with succinyl-CoA
486820
Homo sapiens
5-aminolevulinic acid methyl ester + CoA + CO2
-
-
-
-
2.3.1.37
succinyl-CoA-monomethyl ester + glycine
at 80% the rate of the reaction with succinyl-CoA
486820
Rattus norvegicus
5-aminolevulinic acid methyl ester + CoA + CO2
-
-
-
-
2.3.1.37
succinyl-CoA-monomethyl ester + glycine
at 80% the rate of the reaction with succinyl-CoA
486820
Saccharomyces cerevisiae
5-aminolevulinic acid methyl ester + CoA + CO2
-
-
-
-
2.3.1.37
succinyl-CoA-monomethyl ester + glycine
at 80% the rate of the reaction with succinyl-CoA
486820
Oryctolagus cuniculus
5-aminolevulinic acid methyl ester + CoA + CO2
-
-
-
-
2.3.1.37
succinyl-CoA-monomethyl ester + glycine
at 80% the rate of the reaction with succinyl-CoA
486820
Rhodobacter sphaeroides
5-aminolevulinic acid methyl ester + CoA + CO2
-
-
-
-
2.3.1.37
succinyl-CoA-monomethyl ester + glycine
at 80% the rate of the reaction with succinyl-CoA
486820
Spinacia oleracea
5-aminolevulinic acid methyl ester + CoA + CO2
-
-
-
-
2.3.1.37
succinyl-CoA-monomethyl ester + glycine
at 80% the rate of the reaction with succinyl-CoA
486820
Propionibacterium freudenreichii subsp. shermanii
5-aminolevulinic acid methyl ester + CoA + CO2
-
-
-
-
2.3.1.37
succinyl-CoA-monomethyl ester + glycine
at 80% the rate of the reaction with succinyl-CoA
486820
Rhodospirillum rubrum
5-aminolevulinic acid methyl ester + CoA + CO2
-
-
-
-
Temperature Stability [░C] (protein specific)
EC Number
Temperature Stability Minimum [░C]
Temperature Stability Maximum [░C]
Commentary
Organism
2.3.1.37
additional information
-
-
Rattus norvegicus
2.3.1.37
additional information
-
temperature insensitive
Rhodobacter sphaeroides