BRENDA - Enzyme Database show

Extraction and characterization of delta-aminolevulinate synthetase

Viale, A.A.; Wider, E.A.; Battle, A.M.Del C.; Comp. Biochem. Physiol. B 87, 607-613 (1987)
No PubMed abstract available

Data extracted from this reference:

Activating Compound
EC Number
Activating Compound
Commentary
Organism
Structure
2.3.1.37
additional information
1-2 low molecular-weight compounds which stimulate or stabilize activity found by dialysis of crude extract
Rhodopseudomonas palustris
Inhibitors
EC Number
Inhibitors
Commentary
Organism
Structure
2.3.1.37
delta-aminolevuinate
product inhibition
Rhodopseudomonas palustris
2.3.1.37
additional information
cysteine, glutathione, cystine or 2-mercaptoethanol diminishes activity in presence of 5-aminolevulinate
Rhodopseudomonas palustris
KM Value [mM]
EC Number
KM Value [mM]
KM Value Maximum [mM]
Substrate
Commentary
Organism
Structure
2.3.1.37
additional information
-
additional information
-
Rhodopseudomonas palustris
Molecular Weight [Da]
EC Number
Molecular Weight [Da]
Molecular Weight Maximum [Da]
Commentary
Organism
2.3.1.37
61000
65000
-
Rhodopseudomonas palustris
Organism
EC Number
Organism
Primary Accession No. (UniProt)
Commentary
Textmining
2.3.1.37
Rhodopseudomonas palustris
-
-
-
Source Tissue
EC Number
Source Tissue
Commentary
Organism
Textmining
2.3.1.37
cell culture
-
Rhodopseudomonas palustris
-
Storage Stability
EC Number
Storage Stability
Organism
2.3.1.37
-15°C, not stable
Rhodopseudomonas palustris
2.3.1.37
0-4°C, 18 h stable
Rhodopseudomonas palustris
Substrates and Products (Substrate)
EC Number
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
2.3.1.37
succinyl-CoA + glycine
absolute requirement for glycine
486815
Rhodopseudomonas palustris
5-aminolevulinate + CoA + CO2
-
486815
Rhodopseudomonas palustris
?
2.3.1.37
succinyl-CoA + glycine
absolute requirement for succinyl-CoA
486815
Rhodopseudomonas palustris
5-aminolevulinate + CoA + CO2
-
486815
Rhodopseudomonas palustris
?
Subunits
EC Number
Subunits
Commentary
Organism
2.3.1.37
monomer
1 * 61000-65000
Rhodopseudomonas palustris
Temperature Optimum [°C]
EC Number
Temperature Optimum [°C]
Temperature Optimum Maximum [°C]
Commentary
Organism
2.3.1.37
37
-
-
Rhodopseudomonas palustris
pH Optimum
EC Number
pH Optimum Minimum
pH Optimum Maximum
Commentary
Organism
2.3.1.37
7.5
-
-
Rhodopseudomonas palustris
Cofactor
EC Number
Cofactor
Commentary
Organism
Structure
2.3.1.37
pyridoxal 5'-phosphate
-
Rhodopseudomonas palustris
Activating Compound (protein specific)
EC Number
Activating Compound
Commentary
Organism
Structure
2.3.1.37
additional information
1-2 low molecular-weight compounds which stimulate or stabilize activity found by dialysis of crude extract
Rhodopseudomonas palustris
Cofactor (protein specific)
EC Number
Cofactor
Commentary
Organism
Structure
2.3.1.37
pyridoxal 5'-phosphate
-
Rhodopseudomonas palustris
Inhibitors (protein specific)
EC Number
Inhibitors
Commentary
Organism
Structure
2.3.1.37
delta-aminolevuinate
product inhibition
Rhodopseudomonas palustris
2.3.1.37
additional information
cysteine, glutathione, cystine or 2-mercaptoethanol diminishes activity in presence of 5-aminolevulinate
Rhodopseudomonas palustris
KM Value [mM] (protein specific)
EC Number
KM Value [mM]
KM Value Maximum [mM]
Substrate
Commentary
Organism
Structure
2.3.1.37
additional information
-
additional information
-
Rhodopseudomonas palustris
Molecular Weight [Da] (protein specific)
EC Number
Molecular Weight [Da]
Molecular Weight Maximum [Da]
Commentary
Organism
2.3.1.37
61000
65000
-
Rhodopseudomonas palustris
Source Tissue (protein specific)
EC Number
Source Tissue
Commentary
Organism
Textmining
2.3.1.37
cell culture
-
Rhodopseudomonas palustris
-
Storage Stability (protein specific)
EC Number
Storage Stability
Organism
2.3.1.37
-15°C, not stable
Rhodopseudomonas palustris
2.3.1.37
0-4°C, 18 h stable
Rhodopseudomonas palustris
Substrates and Products (Substrate) (protein specific)
EC Number
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
2.3.1.37
succinyl-CoA + glycine
absolute requirement for glycine
486815
Rhodopseudomonas palustris
5-aminolevulinate + CoA + CO2
-
486815
Rhodopseudomonas palustris
?
2.3.1.37
succinyl-CoA + glycine
absolute requirement for succinyl-CoA
486815
Rhodopseudomonas palustris
5-aminolevulinate + CoA + CO2
-
486815
Rhodopseudomonas palustris
?
Subunits (protein specific)
EC Number
Subunits
Commentary
Organism
2.3.1.37
monomer
1 * 61000-65000
Rhodopseudomonas palustris
Temperature Optimum [°C] (protein specific)
EC Number
Temperature Optimum [°C]
Temperature Optimum Maximum [°C]
Commentary
Organism
2.3.1.37
37
-
-
Rhodopseudomonas palustris
pH Optimum (protein specific)
EC Number
pH Optimum Minimum
pH Optimum Maximum
Commentary
Organism
2.3.1.37
7.5
-
-
Rhodopseudomonas palustris