BRENDA - Enzyme Database show

Soluble delta-aminolevulinic acid synthetase of rat liver. II. Studies related to the mechanism of enzyme action and hemin inhibition

Scholnick, P.L.; Hammaker, L.E.; Marver, H.S.; J. Biol. Chem. 247, 4132-4137 (1972)

Data extracted from this reference:

Inhibitors
EC Number
Inhibitors
Commentary
Organism
Structure
2.3.1.37
bilirubin
-
Rattus norvegicus
2.3.1.37
Co2+
-
Rattus norvegicus
2.3.1.37
deuteroporphyrin
-
Rattus norvegicus
2.3.1.37
divalent cations
at high concentration, relative order of inhibition: Co2+, Mn2+, Mg2+, Ca2+
Rattus norvegicus
2.3.1.37
hemin
-
Rattus norvegicus
2.3.1.37
Iron-deuteroporphyrin
-
Rattus norvegicus
2.3.1.37
Iron-mesoporphyrin
-
Rattus norvegicus
2.3.1.37
Iron-protoporphyrin
-
Rattus norvegicus
2.3.1.37
mesoporphyrin
-
Rattus norvegicus
2.3.1.37
metalloporphyrins
-
Rattus norvegicus
2.3.1.37
Mn2+
-
Rattus norvegicus
2.3.1.37
N-ethylmaleimide
glycine and pyridoxal 5'-phosphate protect
Rattus norvegicus
2.3.1.37
p-chloromercuribenzoate
pyridoxal 5'-phosphate protects
Rattus norvegicus
2.3.1.37
protoporphyrin
-
Rattus norvegicus
Localization
EC Number
Localization
Commentary
Organism
GeneOntology No.
Textmining
2.3.1.37
cytosol
-
Rattus norvegicus
5829
-
Organism
EC Number
Organism
Primary Accession No. (UniProt)
Commentary
Textmining
2.3.1.37
Rattus norvegicus
-
-
-
Reaction
EC Number
Reaction
Commentary
Organism
2.3.1.37
succinyl-CoA + glycine = 5-aminolevulinate + CoA + CO2
mechanism
Rattus norvegicus
Source Tissue
EC Number
Source Tissue
Commentary
Organism
Textmining
2.3.1.37
liver
-
Rattus norvegicus
-
Substrates and Products (Substrate)
EC Number
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
2.3.1.37
succinyl-CoA + glycine
-
486813
Rattus norvegicus
5-aminolevulinate + CoA + CO2
-
486813
Rattus norvegicus
?
Cofactor
EC Number
Cofactor
Commentary
Organism
Structure
2.3.1.37
pyridoxal 5'-phosphate
-
Rattus norvegicus
Ki Value [mM]
EC Number
Ki Value [mM]
Ki Value maximum [mM]
Inhibitor
Commentary
Organism
Structure
2.3.1.37
0.2
-
metalloporphyrin
-
Rattus norvegicus
Cofactor (protein specific)
EC Number
Cofactor
Commentary
Organism
Structure
2.3.1.37
pyridoxal 5'-phosphate
-
Rattus norvegicus
Inhibitors (protein specific)
EC Number
Inhibitors
Commentary
Organism
Structure
2.3.1.37
bilirubin
-
Rattus norvegicus
2.3.1.37
Co2+
-
Rattus norvegicus
2.3.1.37
deuteroporphyrin
-
Rattus norvegicus
2.3.1.37
divalent cations
at high concentration, relative order of inhibition: Co2+, Mn2+, Mg2+, Ca2+
Rattus norvegicus
2.3.1.37
hemin
-
Rattus norvegicus
2.3.1.37
Iron-deuteroporphyrin
-
Rattus norvegicus
2.3.1.37
Iron-mesoporphyrin
-
Rattus norvegicus
2.3.1.37
Iron-protoporphyrin
-
Rattus norvegicus
2.3.1.37
mesoporphyrin
-
Rattus norvegicus
2.3.1.37
metalloporphyrins
-
Rattus norvegicus
2.3.1.37
Mn2+
-
Rattus norvegicus
2.3.1.37
N-ethylmaleimide
glycine and pyridoxal 5'-phosphate protect
Rattus norvegicus
2.3.1.37
p-chloromercuribenzoate
pyridoxal 5'-phosphate protects
Rattus norvegicus
2.3.1.37
protoporphyrin
-
Rattus norvegicus
Ki Value [mM] (protein specific)
EC Number
Ki Value [mM]
Ki Value maximum [mM]
Inhibitor
Commentary
Organism
Structure
2.3.1.37
0.2
-
metalloporphyrin
-
Rattus norvegicus
Localization (protein specific)
EC Number
Localization
Commentary
Organism
GeneOntology No.
Textmining
2.3.1.37
cytosol
-
Rattus norvegicus
5829
-
Source Tissue (protein specific)
EC Number
Source Tissue
Commentary
Organism
Textmining
2.3.1.37
liver
-
Rattus norvegicus
-
Substrates and Products (Substrate) (protein specific)
EC Number
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
2.3.1.37
succinyl-CoA + glycine
-
486813
Rattus norvegicus
5-aminolevulinate + CoA + CO2
-
486813
Rattus norvegicus
?