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Literature summary extracted from

  • Scholnick, P.L.; Hammaker, L.E.; Marver, H.S.
    Souble delta-aminolevulinic acid synthetase of rat liver. I. Some properties of the partially purified enzyme (1972), J. Biol. Chem., 247, 4126-4131.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
2.3.1.37 NaCl required for maximal activity Rattus norvegicus

General Stability

EC Number General Stability Organism
2.3.1.37 partially purified enzyme requires high cation concentration, equivalent to 0.3 M NaCl for maximum stabilization Rattus norvegicus

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
2.3.1.37 0.003
-
 pyridoxal 5'-phosphate
-
 Rattus norvegicus
2.3.1.37 0.025
-
 succinyl-CoA
-
 Rattus norvegicus
2.3.1.37 0.07
-
 succinyl-CoA
-
 Rattus norvegicus
2.3.1.37 10
-
 succinyl-CoA
-
 Rattus norvegicus

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
2.3.1.37 cytosol
-
 Rattus norvegicus 5829
-

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
2.3.1.37 additional information partially purified enzyme requires high cation concentrations, equivalent to 0.3 M NaCl, for maximum activation, monovalent cations, i.e. Na+, K+, Li+, Rb+ or NH4+, in concentrations from 0.15 M to 0.30 M or divalent cations, i.e. Mg2+, Ca2+ or Mn2+, at lower concentrations of 0.03 M to 0.10 M are effective Rattus norvegicus

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
2.3.1.37 295000
-
 gel filtration, presence of NaCl Rattus norvegicus
2.3.1.37 500000
-
 gel filtration, absence of NaCl Rattus norvegicus

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.3.1.37 succinyl-CoA + glycine Rattus norvegicus rate-limiting enzyme of heme biosynthesis 5-aminolevulinate + CoA + CO2
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.3.1.37 Rattus norvegicus
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
2.3.1.37
-
 Rattus norvegicus

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.3.1.37 liver
-
 Rattus norvegicus
-

Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
2.3.1.37 0.018
-
 purified enzyme Rattus norvegicus

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.3.1.37 succinyl-CoA + glycine absolute requirement for glycine Rattus norvegicus 5-aminolevulinate + CoA + CO2
-
 ?
2.3.1.37 succinyl-CoA + glycine absolute requirement for succinyl-CoA Rattus norvegicus 5-aminolevulinate + CoA + CO2
-
 ?
2.3.1.37 succinyl-CoA + glycine rate-limiting enzyme of heme biosynthesis Rattus norvegicus 5-aminolevulinate + CoA + CO2
-
 ?

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
2.3.1.37 7.4 7.6
-
 Rattus norvegicus
2.3.1.37 7.5
-
-
 Rattus norvegicus

pH Stability

EC Number pH Stability pH Stability Maximum Comment Organism
2.3.1.37 6.8 8 unstable below pH 6.8 and above pH 8.0, irreversible loss of activity Rattus norvegicus

Cofactor

EC Number Cofactor Comment Organism Structure
2.3.1.37 pyridoxal 5'-phosphate
-
 Rattus norvegicus