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Literature summary extracted from

  • Ramaswamy, N.K.; Madhusudanan Nair, P.
    delta-Aminolevulinic acid synthetase from cold-stored potatoes (1973), Biochim. Biophys. Acta, 293, 269-277.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
2.3.1.37 ATP activates in assays with crude enzyme extracts Solanum tuberosum
2.3.1.37 CoA activates Solanum tuberosum

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.3.1.37 chlorophyllide a
-
 Solanum tuberosum
2.3.1.37 hemin
-
 Solanum tuberosum
2.3.1.37 light above 30 lux intensity Solanum tuberosum
2.3.1.37 additional information pheophytin and chlorophyll are not inhibitory Solanum tuberosum

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
2.3.1.37 Mg2+ activates Solanum tuberosum

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.3.1.37 succinyl-CoA + glycine Solanum tuberosum
-
 5-aminolevulinate + CoA + CO2 common intermediate in the biosynthesis of chlorophyll and heme ?

Organism

EC Number Organism UniProt Comment Textmining
2.3.1.37 Solanum tuberosum
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.3.1.37 tuber dim light and cold-stored, green skin peeling Solanum tuberosum
-

Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
2.3.1.37 additional information
-
 EDTA required for the assay to inhibit 5-aminolevulinate dehydratase Solanum tuberosum
2.3.1.37 0.0057
-
 maximal enzyme activity after 3 weeks of storage of tubers at 0-15°C at 30 lux Solanum tuberosum

Storage Stability

EC Number Storage Stability Organism
2.3.1.37 -30°C, complete loss of activity overnight Solanum tuberosum

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.3.1.37 succinyl-CoA + glycine
-
 Solanum tuberosum 5-aminolevulinate + CoA + CO2
-
 ?
2.3.1.37 succinyl-CoA + glycine
-
 Solanum tuberosum 5-aminolevulinate + CoA + CO2 common intermediate in the biosynthesis of chlorophyll and heme ?

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
2.3.1.37 15
-
-
 Solanum tuberosum

Temperature Stability [°C]

EC Number Temperature Stability Minimum [°C] Temperature Stability Maximum [°C] Comment Organism
2.3.1.37 additional information
-
 room temperature, inactivation within 30 min Solanum tuberosum

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
2.3.1.37 7
-
-
 Solanum tuberosum

Cofactor

EC Number Cofactor Comment Organism Structure
2.3.1.37 pyridoxal 5'-phosphate required Solanum tuberosum
2.3.1.37 pyridoxal 5'-phosphate activates Solanum tuberosum