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Literature summary extracted from

  • Edgar, A.J.; Polak, J.M.
    Molecular cloning of the human and murine 2-amino-3-ketobutyrate coenzyme A ligase cDNAs (2000), Eur. J. Biochem., 267, 1805-1812.
    View publication on PubMed

Cloned(Commentary)

EC Number Cloned (Comment) Organism
2.3.1.29 bovine partial Mus musculus
2.3.1.29 bovine partial Homo sapiens
2.3.1.29 bovine partial Bos taurus
2.3.1.29 bovine partial Escherichia coli
2.3.1.29 expressed in Escherichia coli Mus musculus
2.3.1.29 expressed in Escherichia coli Homo sapiens
2.3.1.29 expressed in Escherichia coli Bos taurus
2.3.1.29 expressed in Escherichia coli Escherichia coli

Crystallization (Commentary)

EC Number Crystallization (Comment) Organism
2.3.1.29 external aldimine in the crystal structure, interaction between aldimine and the side chains in the substrate binding site explain the specificity to the substrate Escherichia coli

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
2.3.1.29 cytoplasm enzyme synthesized in cytoplasm Homo sapiens 5737
-
2.3.1.29 mitochondrion
-
 Mus musculus 5739
-
2.3.1.29 mitochondrion
-
 Bos taurus 5739
-
2.3.1.29 mitochondrion enzyme imported into mitochondrion from cytoplasm Homo sapiens 5739
-

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
2.3.1.29 43000
-
 2 * 43000, SDS-PAGE Escherichia coli
2.3.1.29 80000
-
 dynamic ligth scattering measurement Escherichia coli

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.3.1.29 acetyl-CoA + glycine Mus musculus enzyme catalyzes the second reaction step on the main metabolic degradation pathway for threonine CoA + 2-amino-3-oxobutanoate
-
 ?
2.3.1.29 acetyl-CoA + glycine Homo sapiens enzyme catalyzes the second reaction step on the main metabolic degradation pathway for threonine CoA + 2-amino-3-oxobutanoate
-
 ?
2.3.1.29 acetyl-CoA + glycine Bos taurus enzyme catalyzes the second reaction step on the main metabolic degradation pathway for threonine CoA + 2-amino-3-oxobutanoate
-
 ?
2.3.1.29 acetyl-CoA + glycine Escherichia coli enzyme catalyzes the second reaction step on the main metabolic degradation pathway for threonine CoA + 2-amino-3-oxobutanoate
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.3.1.29 Bos taurus
-
-
-
2.3.1.29 Escherichia coli P0AB77
-
-
2.3.1.29 Homo sapiens
-
-
-
2.3.1.29 Mus musculus
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
2.3.1.29
-
 Bos taurus
2.3.1.29
-
 Escherichia coli

Reaction

EC Number Reaction Comment Organism Reaction ID
2.3.1.29 acetyl-CoA + glycine = CoA + L-2-amino-3-oxobutanoate reaction mechanism Escherichia coli
a

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.3.1.29 brain
-
 Homo sapiens
-
2.3.1.29 heart
-
 Homo sapiens
-
2.3.1.29 liver
-
 Bos taurus
-
2.3.1.29 lung
-
 Mus musculus
-
2.3.1.29 lung
-
 Homo sapiens
-
2.3.1.29 pancreas
-
 Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.3.1.29 acetyl-CoA + glycine
-
 Mus musculus CoA + 2-amino-3-oxobutanoate spontaneous decarboxylation to aminoacetone r
2.3.1.29 acetyl-CoA + glycine
-
 Homo sapiens CoA + 2-amino-3-oxobutanoate spontaneous decarboxylation to aminoacetone r
2.3.1.29 acetyl-CoA + glycine
-
 Bos taurus CoA + 2-amino-3-oxobutanoate spontaneous decarboxylation to aminoacetone r
2.3.1.29 acetyl-CoA + glycine
-
 Escherichia coli CoA + 2-amino-3-oxobutanoate spontaneous decarboxylation to aminoacetone ?
2.3.1.29 acetyl-CoA + glycine enzyme catalyzes the second reaction step on the main metabolic degradation pathway for threonine Mus musculus CoA + 2-amino-3-oxobutanoate
-
 ?
2.3.1.29 acetyl-CoA + glycine enzyme catalyzes the second reaction step on the main metabolic degradation pathway for threonine Homo sapiens CoA + 2-amino-3-oxobutanoate
-
 ?
2.3.1.29 acetyl-CoA + glycine enzyme catalyzes the second reaction step on the main metabolic degradation pathway for threonine Bos taurus CoA + 2-amino-3-oxobutanoate
-
 ?
2.3.1.29 acetyl-CoA + glycine enzyme catalyzes the second reaction step on the main metabolic degradation pathway for threonine Escherichia coli CoA + 2-amino-3-oxobutanoate
-
 ?

Subunits

EC Number Subunits Comment Organism
2.3.1.29 dimer
-
 Bos taurus
2.3.1.29 dimer 2 * 43000, SDS-PAGE Escherichia coli

Cofactor

EC Number Cofactor Comment Organism Structure
2.3.1.29 pyridoxal 5'-phosphate
-
 Bos taurus
2.3.1.29 pyridoxal 5'-phosphate
-
 Escherichia coli