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Literature summary extracted from

  • Bhuvaneswaran, C.; Synouri-Vrettakou, S.; Mitropoulos, K.A.
    Activation of acyl-CoA:cholesterol acyltransferase in rat liver microsomes by 25-hydroxycholesterol (1997), Biochem. Pharmacol., 53, 27-34.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
2.3.1.26 25-hydroxycholesterol stimulates enzyme activity in liver microsomes in vitro with half-maximal stimulation at 0.0168 mM oxysterol. A major part of the activation of microsomal enzyme is not ascribable to increased substrate availability for the enzyme Rattus norvegicus

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
2.3.1.26 microsome
-
 Rattus norvegicus
-
-

Organism

EC Number Organism UniProt Comment Textmining
2.3.1.26 Rattus norvegicus
-
 male Wistar strain
-
2.3.1.26 Rattus norvegicus male Wistar
-
 male Wistar strain
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.3.1.26 liver
-
 Rattus norvegicus
-

Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
2.3.1.26 0.0000582
-
 microsomal fraction without 25-hydroycholesterol Rattus norvegicus
2.3.1.26 0.0000982
-
 microsomal fraction with 25-hydroycholesterol Rattus norvegicus

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.3.1.26 oleoyl-CoA + cholesterol
-
 Rattus norvegicus CoA + cholesteryl oleate
-
 ?
2.3.1.26 oleoyl-CoA + cholesterol
-
 Rattus norvegicus male Wistar CoA + cholesteryl oleate
-
 ?