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Literature summary extracted from

  • Taketani, S.; Nishino, T.; Katsuki, H.
    Characterization of sterol-ester synthetase in Saccharomyces cerevisiae (1979), Biochim. Biophys. Acta, 575, 148-155.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.3.1.26 acetone about 40% inhibition at a final concentration of 1% v/v Saccharomyces cerevisiae
2.3.1.26 butanol about 40% inhibition at a final concentration of 1% v/v Saccharomyces cerevisiae
2.3.1.26 ethanol about 40% inhibition at a final concentration of 1% v/v Saccharomyces cerevisiae

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
2.3.1.26 0.06
-
 cholesterol with oleoyl-CoA Saccharomyces cerevisiae
2.3.1.26 0.069
-
 oleoyl-CoA
-
 Saccharomyces cerevisiae

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
2.3.1.26 microsome
-
 Saccharomyces cerevisiae
-
-
2.3.1.26 spheroplast
-
 Saccharomyces cerevisiae
-
-

Organism

EC Number Organism UniProt Comment Textmining
2.3.1.26 Saccharomyces cerevisiae
-
-
-

Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
2.3.1.26 additional information
-
-
 Saccharomyces cerevisiae

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.3.1.26 acetyl-CoA + cholesterol 16% of the activity with oleoyl-CoA Saccharomyces cerevisiae CoA + cholesteryl acetate
-
 ?
2.3.1.26 acyl-CoA + cholesterol acyl-CoA derivatives can be replaced by ATP, Mg2+, CoA and fatty acids, in-situ production of acyl-CoA Saccharomyces cerevisiae CoA + cholesterol ester
-
 ?
2.3.1.26 lauroyl-CoA + cholesterol 62% of the activity with oleoyl-CoA Saccharomyces cerevisiae CoA + cholesteryl laurate
-
 ?
2.3.1.26 additional information the enzyme has a broad substrate specificity for sterols and acyl-CoAs Saccharomyces cerevisiae ?
-
 ?
2.3.1.26 myristoyl-CoA + cholesterol 37% of the activity with oleoyl-CoA Saccharomyces cerevisiae CoA + cholesteryl myristate
-
 ?
2.3.1.26 oleoyl-CoA + cholesterol highest activity Saccharomyces cerevisiae CoA + cholesteryl oleate
-
 ?
2.3.1.26 oleoyl-CoA + episterol 62% of the activity with cholesterol Saccharomyces cerevisiae CoA + episteryl oleate
-
 ?
2.3.1.26 oleoyl-CoA + ergosterol 147% of the activity with cholesterol Saccharomyces cerevisiae CoA + ergosteryl oleate
-
 ?
2.3.1.26 oleoyl-CoA + fecosterol 48% of the activity with cholesterol Saccharomyces cerevisiae CoA + fecosteryl oleate
-
 ?
2.3.1.26 oleoyl-CoA + lanosterol 65% of the activity with cholesterol Saccharomyces cerevisiae CoA + lanosteryl oleate
-
 ?
2.3.1.26 oleoyl-CoA + zymosterol 93% of the activity with cholesterol Saccharomyces cerevisiae CoA + zymosteryl oleate
-
 ?
2.3.1.26 palmitoleoyl-CoA + cholesterol 91% of the activity with oleoyl-CoA Saccharomyces cerevisiae CoA + cholesteryl palmitoleate
-
 ?
2.3.1.26 palmitoyl-CoA + cholesterol 47% of the activity with oleoyl-CoA Saccharomyces cerevisiae CoA + cholesteryl palmitate
-
 ?

Cofactor

EC Number Cofactor Comment Organism Structure
2.3.1.26 CoA required by the in-situ acyl-CoA production Saccharomyces cerevisiae