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Literature summary extracted from

  • Kerkhoff, C.; Habben, K.; Gehring, L.; Resch, K.; Kaever, V.
    Substrate specificity of acyl-CoA:lysophospholipid acyltransferase (LAT) from pig spleen (1998), Arch. Biochem. Biophys., 351, 220-226.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
2.3.1.23 ethanol integral membrane enzyme, 2% (v/v), 30% increase in activity Sus scrofa

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.3.1.23 arachidonic acid 0.045 mM, 50% inhibition Sus scrofa
2.3.1.23 ethanol integral membrane enzyme, 10%, 20% inhibition Sus scrofa
2.3.1.23 oleic acid 0.08 mM, 50% inhibition Sus scrofa
2.3.1.23 palmitic acid 0.15 mM, 50% inhibition Sus scrofa
2.3.1.23 palmitoyl-CoA 0.2 mM, 50% inhibition Sus scrofa
2.3.1.23 palmitoyltrifluoromethylketone 0.15 mM, 50% inhibition Sus scrofa

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
2.3.1.23 membrane
-
 Sus scrofa 16020
-

Organism

EC Number Organism UniProt Comment Textmining
2.3.1.23 Sus scrofa
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
2.3.1.23 partial purification with palmitoyl-CoA-agarose affinity chromatography Sus scrofa

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.3.1.23 spleen
-
 Sus scrofa
-

Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
2.3.1.23 0.042
-
 integral membrane enzyme, 1-palmitoyl-glycero-3-phosphocholine as substrate Sus scrofa

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.3.1.23 acyl-CoA + 1-acyl-sn-glycero-3-phosphocholine
-
 Sus scrofa CoA + 1,2-diacyl-sn-glycero-3-phosphocholine
-
 r
2.3.1.23 acyl-CoA + 1-decanoyl-sn-glycero-3-phosphocholine
-
 Sus scrofa CoA + 1-decanoyl-2-acyl-sn-glycero-3-phosphocholine
-
 ?
2.3.1.23 acyl-CoA + 1-lauroyl-sn-glycero-3-phosphocholine
-
 Sus scrofa CoA + 1-lauroyl-2-acyl-sn-glycero-3-phosphocholine
-
 ?
2.3.1.23 acyl-CoA + 1-oleoyl-sn-glycero-3-phosphocholine integral membrane enzyme, preferred acyl acceptors in descending order: 1-oleoyl-sn-glycero-3-phosphocholine, 1-stearoyl-sn-glycero-3-phosphocholine, 1-palmitoyl-sn-glycero-3-phosphocholine, 1-myristoyl-sn-glycero-3-phosphocholine, 1-lauroyl-sn-glycero-3-phosphocholine and 1-decanoyl-sn-glycero-3-phosphocholine Sus scrofa CoA + 1-oleoyl-2-acyl-sn-glycero-3-phosphocholine
-
 ?