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Literature summary extracted from

  • Nic a'Bhaird, N.; Yankovskaya, V.; Ramsay, R.R.
    Active sites residues of beef liver carnitine octanoyltransferase (COT) and carnitine palmitoyltransferase (CPT-II) (1998), Biochem. J., 330, 1029-1036.
No PubMed abstract available

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.3.1.21 diethyl dicarbonate CPT II, strong, linear pseudo-first order kinetic, modification of a histidine residue, reversible by hydroxylamine, decanoyl-CoA and L-carnitine Bos taurus

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.3.1.21 acyl-CoA + L-carnitine Bos taurus
-
 CoA + L-acylcarnitine
-
 r

Organism

EC Number Organism UniProt Comment Textmining
2.3.1.21 Bos taurus
-
 CPT II
-

Purification (Commentary)

EC Number Purification (Comment) Organism
2.3.1.21 CPT II Bos taurus

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.3.1.21 liver CPT II Bos taurus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.3.1.21 acyl-CoA + L-carnitine
-
 Bos taurus CoA + L-acylcarnitine
-
 r
2.3.1.21 decanoyl-CoA + L-carnitine
-
 Bos taurus CoA + L-decanoylcarnitine
-
 r

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
2.3.1.21 7.4
-
 assay at Bos taurus