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Literature summary extracted from

  • Singh, H.; Poulos, A.
    Substrate specificity of rat liver mitochondrial carnitine palmitoyl transferase I: evidence against alpha-oxidation of phytanic acid in rat liver mitochondria (1995), FEBS Lett., 359, 179-183.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.3.1.21 malonyl-CoA inhibition is pH-dependent; inhibition is temperature dependent Rattus norvegicus

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
2.3.1.21 additional information
-
 additional information kinetics Rattus norvegicus
2.3.1.21 0.042
-
 L-carnitine
-
 Rattus norvegicus
2.3.1.21 0.055
-
 palmitoyl-CoA
-
 Rattus norvegicus

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
2.3.1.21 mitochondrion
-
 Rattus norvegicus 5739
-

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.3.1.21 acyl-CoA + L-carnitine Rattus norvegicus
-
 CoA + L-acylcarnitine
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.3.1.21 Rattus norvegicus
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.3.1.21 liver
-
 Rattus norvegicus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.3.1.21 acyl-CoA + L-carnitine
-
 Rattus norvegicus CoA + L-acylcarnitine
-
 ?
2.3.1.21 additional information the branched chain fatty acid CoA-thioesters pristanoyl-CoA and phytanoyl-CoA, i.e. 2,6,10,14-tetramethylhexadecanoyl-CoA and 3,7,11,15-tetramethylhexadecanoyl-CoA, are no substrates in vivo, since they cannot be transported into mitochondria of liver Rattus norvegicus ?
-
 ?
2.3.1.21 palmitoyl-CoA + L-carnitine
-
 Rattus norvegicus CoA + L-palmitoylcarnitine
-
 ?
2.3.1.21 stearoyl-CoA + L-carnitine
-
 Rattus norvegicus CoA + L-stearoylcarnitine
-
 ?