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Literature summary extracted from

  • Gandour, R.D.; Colucci, W.J.; Stelly, T.C.; Brady, P.S.; Brady, L.J.
    Hemipalmitoylcarnitinium, a strong competitive inhibitor of purified hepatic carnitine palmitoyltransferase (1988), Arch. Biochem. Biophys., 267, 515-520.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.3.1.21 Hemipalmitoylcarnitinium bromide competitve to palmitoyl-carnitine in the reverse reaction; i.e. HPC, 2S,6R:2R,6S-6-carboxymethyl-2-hydroxy-2-pentadecyl-4,4-dimethylmorpholinium bromide Rattus norvegicus
2.3.1.21 L-palmitoylcarnitine competitive product inhibition Rattus norvegicus
2.3.1.21 additional information no inhibition by choline, hemiacetylcarnitinium Rattus norvegicus
2.3.1.21 palmitoylcarnitine
-
 Rattus norvegicus
2.3.1.21 Palmitoylcholine competitive in the forward reaction to both substrates Rattus norvegicus

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.3.1.21 acyl-CoA + L-carnitine Rattus norvegicus
-
 CoA + L-acylcarnitine
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.3.1.21 Rattus norvegicus
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.3.1.21 liver
-
 Rattus norvegicus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.3.1.21 acyl-CoA + L-carnitine
-
 Rattus norvegicus CoA + L-acylcarnitine
-
 ?
2.3.1.21 palmitoyl-CoA + L-carnitine
-
 Rattus norvegicus CoA + L-palmitoylcarnitine
-
 r

Ki Value [mM]

EC Number Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
2.3.1.21 0.0016
-
 Hemipalmitoylcarnitinium bromide with palmitoyl-carnitine, reverse reaction Rattus norvegicus
2.3.1.21 0.0051
-
 Hemipalmitoylcarnitinium bromide with carnitine, forward reaction Rattus norvegicus
2.3.1.21 0.009
-
 palmitoylcarnitine versus palmitoyl-CoA Rattus norvegicus
2.3.1.21 0.0104
-
 Palmitoylcholine versus palmitoyl-CoA Rattus norvegicus
2.3.1.21 0.014
-
 palmitoylcarnitine versus carnitine Rattus norvegicus
2.3.1.21 0.019
-
 Palmitoylcholine versus carnitine Rattus norvegicus
2.3.1.21 0.0215
-
 Hemipalmitoylcarnitinium bromide with palmitoyl-CoA, forward reaction Rattus norvegicus