Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary extracted from

  • Fiol, C.J.; Bieber, L.L.
    Sigmoid kinetics of purified beef heart mitochondrial carnitine palmitoyltransferase. Effect of pH and malonyl-CoA (1984), J. Biol. Chem., 259, 13084-13088.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.3.1.21 malonyl-CoA no inhibition Bos taurus

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
2.3.1.21 additional information
-
 additional information effects of malonyl-CoA on kinetics Bos taurus
2.3.1.21 0.0242
-
 palmitoyl-CoA
-
 Bos taurus

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
2.3.1.21 membrane membrane-bound Bos taurus 16020
-
2.3.1.21 mitochondrion
-
 Bos taurus 5739
-

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
2.3.1.21 67000
-
 gel filtration Bos taurus

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.3.1.21 acyl-CoA + L-carnitine Bos taurus
-
 CoA + L-acylcarnitine
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.3.1.21 Bos taurus
-
-
-

Posttranslational Modification

EC Number Posttranslational Modification Comment Organism
2.3.1.21 lipoprotein 18.9 mol of bound phospholipid per mol of enzyme, cardiolipin phosphatidylethanolamine and phosphatidylcholine Bos taurus

Purification (Commentary)

EC Number Purification (Comment) Organism
2.3.1.21
-
 Bos taurus

Reaction

EC Number Reaction Comment Organism Reaction ID
2.3.1.21 palmitoyl-CoA + L-carnitine = CoA + L-palmitoylcarnitine sigmoidal kinetics with both substrates Bos taurus
a

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.3.1.21 heart
-
 Bos taurus
-

Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
2.3.1.21 42
-
 purified enzyme Bos taurus

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.3.1.21 acyl-CoA + L-carnitine
-
 Bos taurus CoA + L-acylcarnitine
-
 ?
2.3.1.21 palmitoyl-CoA + L-carnitine
-
 Bos taurus CoA + L-palmitoylcarnitine
-
 ?

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
2.3.1.21 25
-
 assay at Bos taurus

pH Range

EC Number pH Minimum pH Maximum Comment Organism
2.3.1.21 6 8
-
 Bos taurus