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Literature summary extracted from

  • Mathieu, M.; Zeelen, J.P.; Pauptit, R.A.; Erdmann, R.; Kunau, W.H.; Wierenga, R.K.
    The 2.8 ANG. crystal structure of peroxisomal 3-ketoacyl-CoA thiolase of Saccharomyces cerevisiae: a five-layered alpha,beta,alpha,beta,alpha structure constructed from two core domains of identical topology (1994), Structure, 2, 797-808.
    View publication on PubMed

Application

EC Number Application Comment Organism
2.3.1.16 medicine mutation in the thiolase gene causes severe health problems, such as ketoacidic attacks at the age of six months followed by severe retardation Saccharomyces cerevisiae

Crystallization (Commentary)

EC Number Crystallization (Comment) Organism
2.3.1.16
-
Saccharomyces cerevisiae

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
2.3.1.16 cytosol enzyme is synthesized in the cytosol and subsequently imported into the peroxisome Saccharomyces cerevisiae 5829
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Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.3.1.16 CoA + 3-oxoacyl-CoA Saccharomyces cerevisiae enzyme catalyses the last step in the beta-oxidation cycle acyl-CoA + acetyl-CoA
-
?

Organism

EC Number Organism UniProt Comment Textmining
2.3.1.16 Saccharomyces cerevisiae
-
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.3.1.16 CoA + 3-oxoacyl-CoA
-
Saccharomyces cerevisiae acyl-CoA + acetyl-CoA
-
?
2.3.1.16 CoA + 3-oxoacyl-CoA enzyme catalyses the last step in the beta-oxidation cycle Saccharomyces cerevisiae acyl-CoA + acetyl-CoA
-
?

Subunits

EC Number Subunits Comment Organism
2.3.1.16 dimer
-
Saccharomyces cerevisiae