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Literature summary extracted from

  • Datta, N.S.; Hajra, A.K.
    Does microsomal glycerophosphate acyltransferase also catalyze the acylation of dihydroxyacetone phosphate? (1984), FEBS Lett., 176, 264-268.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
2.3.1.42 deoxycholate at low concentration Rattus norvegicus
2.3.1.42 Triton X-100 stimulation, up to 0.2 mg/ml Rattus norvegicus

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.3.1.15 N-ethylmaleimide
-
 Rattus norvegicus
2.3.1.15 Triton X-100
-
 Rattus norvegicus
2.3.1.42 deoxycholate weak, high concentration Rattus norvegicus
2.3.1.42 glycerol 3-phosphate weak Rattus norvegicus
2.3.1.42 N-ethylmaleimide no inhibition Rattus norvegicus
2.3.1.42 Triton X-100 stimulation up to 0.2 mg/ml; weak Rattus norvegicus
2.3.1.42 Trypsin not sensitive against Rattus norvegicus

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
2.3.1.15 microsome
-
 Rattus norvegicus
-
-
2.3.1.42 microsome
-
 Rattus norvegicus
-
-

Organism

EC Number Organism UniProt Comment Textmining
2.3.1.15 Rattus norvegicus
-
 male
-
2.3.1.15 Rattus norvegicus
-
 Sprague-Dawley strain
-
2.3.1.15 Rattus norvegicus Sprague-Dawley
-
 Sprague-Dawley strain
-
2.3.1.42 Rattus norvegicus
-
 male Sprague-Dawley
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.3.1.42 liver
-
 Rattus norvegicus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.3.1.15 palmitoyl-CoA + sn-glycerol 3-phosphate
-
 Rattus norvegicus CoA + 1-palmitoyl-sn-glycerol 3-phosphate
-
 ?
2.3.1.15 palmitoyl-CoA + sn-glycerol 3-phosphate
-
 Rattus norvegicus Sprague-Dawley CoA + 1-palmitoyl-sn-glycerol 3-phosphate
-
 ?
2.3.1.42 acyl-CoA + dihydroxyacetone phosphate
-
 Rattus norvegicus CoA + acyldihydroxyacetone phosphate i.e. acylglycerone phosphate ?
2.3.1.42 acyl-CoA + dihydroxyacetone phosphate
-
 Rattus norvegicus Sprague-Dawley CoA + acyldihydroxyacetone phosphate i.e. acylglycerone phosphate ?
2.3.1.42 palmitoyl-CoA + dihydroxyacetone phosphate
-
 Rattus norvegicus CoA + monopalmitoyldihydroxyacetone phosphate
-
 ?
2.3.1.42 palmitoyl-CoA + dihydroxyacetone phosphate
-
 Rattus norvegicus Sprague-Dawley CoA + monopalmitoyldihydroxyacetone phosphate
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.3.1.15 More enzyme not identical with EC 2.3.1.42 Rattus norvegicus

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
2.3.1.42 37
-
 assay at Rattus norvegicus

Temperature Stability [°C]

EC Number Temperature Stability Minimum [°C] Temperature Stability Maximum [°C] Comment Organism
2.3.1.42 additional information
-
 membrane-bound: heat-stable Rattus norvegicus
2.3.1.42 50
-
 intact microsomes: 25% loss of activity after 30 min Rattus norvegicus
2.3.1.42 55
-
 15 min, stable Rattus norvegicus

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
2.3.1.42 7.4
-
-
 Rattus norvegicus

pH Range

EC Number pH Minimum pH Maximum Comment Organism
2.3.1.15 6.6 8.6 approx. half-maximal activity at pH 6.6 and 8.6 Rattus norvegicus
2.3.1.42 5.5 9.5 about half-maximal activity at pH 5.5 and pH 9.5 Rattus norvegicus