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Literature summary extracted from

  • Hegardt, F.G.; Bach, M.; Asins, G.; Caudevilla, C.; Morillas, M.; Codony, C.; Serra, D.
    Post-transcriptional regulation of rat carnitine octanoyltransferase (2001), Biochem. Soc. Trans., 29, 316-320.
    View publication on PubMed

Cloned(Commentary)

EC Number Cloned (Comment) Organism
2.3.1.137 pYES2 plasmid containing the wild-type and the double mutant H131A/H340A of COT expressed in Saccharomyces cerevisiae Rattus norvegicus

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.3.1.137 etomoxir hypoglycaemia-inducing drug, double mutant H131A/H340A is insensitive to etomoxir Rattus norvegicus
2.3.1.137 malonyl-CoA double mutant H131A/H340A is insensitive to malonyl-CoA Rattus norvegicus

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
2.3.1.137 0.002
-
 decanoyl-CoA recombinant enzyme expressed in Saccharomyces cerevisiae pYESCOTwt Rattus norvegicus
2.3.1.137 0.013
-
 decanoyl-CoA recombinant enzyme expressed in Saccharomyces cerevisiae pYESCOTH340A/H131 Rattus norvegicus
2.3.1.137 0.172
-
 L-carnitine recombinant enzyme expressed in Saccharomyces cerevisiae pYESCOTwt Rattus norvegicus

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
2.3.1.137 peroxisome
-
 Rattus norvegicus 5777
-

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.3.1.137 acyl-CoA + L-carnitine Rattus norvegicus
-
 acyl-L-carnitine + CoA
-
 r

Organism

EC Number Organism UniProt Comment Textmining
2.3.1.137 Rattus norvegicus
-
 rat
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.3.1.137 acyl-CoA + L-carnitine
-
 Rattus norvegicus acyl-L-carnitine + CoA
-
 r
2.3.1.137 decanoyl-CoA + L-carnitine
-
 Rattus norvegicus L-decanoyl-L-carnitine + CoA
-
 r
2.3.1.137 decanoyl-L-carnitine + CoA
-
 Rattus norvegicus decanoyl-CoA + L-carnitine
-
 r