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Literature summary extracted from

  • Ramsay, R.R.; Gandour, R.D.
    Selective modulation of carnitine long-chain acyltransferase activities: Kinetics, inhibitors, and active sites of COT and CPT-II (1999), Adv. Exp. Med. Biol., 466, 103-109.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.3.1.137 hemiacylcarnitinium
-
 Bos taurus
2.3.1.137 hemicholinium
-
 Bos taurus

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
2.3.1.137 0.34
-
 decanoyl-CoA
-
 Bos taurus
2.3.1.137 7.4
-
 palmitoyl-L-carnitine
-
 Bos taurus
2.3.1.137 8.4
-
 Decanoyl-L-carnitine
-
 Bos taurus
2.3.1.137 16
-
 acetyl-CoA
-
 Bos taurus
2.3.1.137 108
-
 L-carnitine
-
 Bos taurus
2.3.1.137 143
-
 choline mutant [Asn505]COT Bos taurus
2.3.1.137 160
-
 L-carnitine mutant [Asn505]COT Bos taurus

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
2.3.1.137 endoplasmic reticulum
-
 Bos taurus 5783
-
2.3.1.137 peroxisome
-
 Bos taurus 5777
-

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.3.1.137 acyl-CoA + L-carnitine Bos taurus
-
 acyl-L-carnitine + CoA
-
 r

Organism

EC Number Organism UniProt Comment Textmining
2.3.1.137 Bos taurus
-
 beef
-

Purification (Commentary)

EC Number Purification (Comment) Organism
2.3.1.137
-
 Bos taurus

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.3.1.137 liver
-
 Bos taurus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.3.1.137 acetyl-CoA + L-carnitine
-
 Bos taurus CoA + acetyl-carnitine
-
 ?
2.3.1.137 acyl-CoA + L-carnitine
-
 Bos taurus acyl-L-carnitine + CoA
-
 r
2.3.1.137 choline + L-carnitine
-
 Bos taurus ?
-
 ?
2.3.1.137 decanoyl-L-carnitine + CoA
-
 Bos taurus decanoyl-CoA + L-carnitine
-
 ?
2.3.1.137 palmitoyl-L-carnitine + CoA
-
 Bos taurus palmitoyl-CoA + L-carnitine
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.3.1.137 COT
-
 Bos taurus

Ki Value [mM]

EC Number Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
2.3.1.137 113
-
 hemiacylcarnitinium
-
 Bos taurus