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Literature summary extracted from

  • Ferdinandusse, S.; Mulders, J.; IJlst, L.; Denis, S.; Dacremont, G.; Waterham, H.R.; Wanders, R.J.A.
    Molecular cloning and expression of human carnitine octanoyltransferase: Evidence for its role in the peroxisomal beta-oxidation of branched-chain fatty acids (1999), Biochem. Biophys. Res. Commun., 263, 213-218.
    View publication on PubMed

Cloned(Commentary)

EC Number Cloned (Comment) Organism
2.3.1.137 cDNA PCR amplified, cloned in yeast expression vector pEL26 and expressed in Saccharomyces cerevisiae Homo sapiens

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
2.3.1.137 peroxisome
-
 Bos taurus 5777
-

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
2.3.1.137 66000
-
 recombinant enzyme, expressed in Saccharomyces cerevisiae Homo sapiens
2.3.1.137 70000
-
 calculated from cDNA sequence Homo sapiens

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.3.1.137 acyl-CoA + L-carnitine Bos taurus
-
 acyl-L-carnitine + CoA
-
 r
2.3.1.137 acyl-CoA + L-carnitine Homo sapiens
-
 acyl-L-carnitine + CoA
-
 r
2.3.1.137 acyl-CoA + L-carnitine Rattus norvegicus
-
 acyl-L-carnitine + CoA
-
 r
2.3.1.137 L-carnitine + octanoyl-CoA Bos taurus
-
 octanoyl-L-carnitine + CoA
-
 r
2.3.1.137 octanoyl-L-carnitine + CoA Bos taurus
-
 L-carnitine + octanoyl-CoA
-
 r

Organism

EC Number Organism UniProt Comment Textmining
2.3.1.137 Bos taurus
-
-
-
2.3.1.137 Bos taurus O19094 SwissProt accession number U65745
-
2.3.1.137 Homo sapiens Q9UKG9 GenBank accession number AF168793
-
2.3.1.137 no activity in Saccharomyces cerevisiae
-
-
-
2.3.1.137 Rattus norvegicus P11466 SwissProt accession number U26033
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.3.1.137 fibroblast skin fibroblast Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.3.1.137 4,8-dimethylnonanoyl-CoA + L-carnitine
-
 Homo sapiens 4,8-dimethylnonanoyl-L-carnitine + CoA
-
 r
2.3.1.137 4,8-dimethylnonanoyl-L-carnitine + CoA
-
 Homo sapiens 4,8-dimethylnonanoyl-CoA + L-carnitine
-
 r
2.3.1.137 acyl-CoA + L-carnitine
-
 Bos taurus acyl-L-carnitine + CoA
-
 r
2.3.1.137 acyl-CoA + L-carnitine
-
 Homo sapiens acyl-L-carnitine + CoA
-
 r
2.3.1.137 acyl-CoA + L-carnitine
-
 Rattus norvegicus acyl-L-carnitine + CoA
-
 r
2.3.1.137 decanoyl-CoA + L-carnitine
-
 Homo sapiens L-decanoyl-L-carnitine + CoA
-
 r
2.3.1.137 dodecanoyl-CoA + L-carnitine
-
 Bos taurus L-dodecanoyl-L-carnitine + CoA
-
 r
2.3.1.137 dodecanoyl-L-carnitine + CoA
-
 Bos taurus dodecanoyl-CoA + L-carnitine
-
 r
2.3.1.137 heptanoyl-CoA + L-carnitine
-
 Homo sapiens L-heptanoyl-L-carnitine + CoA
-
 r
2.3.1.137 hexadecanoyl-L-carnitine + CoA
-
 Bos taurus hexadecanoyl-CoA + L-carnitine
-
 r
2.3.1.137 hexanoyl-CoA + L-carnitine
-
 Bos taurus CoA + L-hexanoylcarnitine
-
 r
2.3.1.137 L-carnitine + octanoyl-CoA
-
 Bos taurus octanoyl-L-carnitine + CoA
-
 r
2.3.1.137 L-hexanoylcarnitine + CoA
-
 Bos taurus hexanoyl-CoA + L-carnitine
-
 r
2.3.1.137 additional information 2,6-dimethyl-heptanoyl-CoA is not a substrate Homo sapiens ?
-
 ?
2.3.1.137 octanoyl-L-carnitine + CoA
-
 Bos taurus L-carnitine + octanoyl-CoA
-
 r

Subunits

EC Number Subunits Comment Organism
2.3.1.137 monomer
-
 Bos taurus
2.3.1.137 monomer 1 * 66000, SDS-PAGE Homo sapiens

Synonyms

EC Number Synonyms Comment Organism
2.3.1.137 COT
-
 Bos taurus