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Literature summary extracted from

  • Nic A'Bhaird, N.; Ramsay, R.R.
    Malonyl-CoA inhibition of peroxisomal carnitine octanoyltransferase (1992), Biochem. J., 286, 637-640.
    View publication on PubMedView publication on EuropePMC

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.3.1.137 malonyl-CoA inhibits the purified enzyme, inhibition is affected by buffer, pH, substrate and presence or absence of bovine serum albumin Rattus norvegicus

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
2.3.1.137 0.00024
-
 decanoyl-CoA pH 6.8 Rattus norvegicus
2.3.1.137 0.00034
-
 decanoyl-CoA pH 7.4 Rattus norvegicus
2.3.1.137 0.00046
-
 palmitoyl-CoA peroxisomal COT Rattus norvegicus
2.3.1.137 0.00047
-
 palmitoyl-CoA pH 6.8 Rattus norvegicus
2.3.1.137 0.0006
-
 palmitoyl-CoA purified COT, pH 7.4 Rattus norvegicus
2.3.1.137 0.102
-
 L-carnitine pH 7.4 Rattus norvegicus
2.3.1.137 0.227
-
 L-carnitine pH 6.8 Rattus norvegicus

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
2.3.1.137 mitochondrion
-
 Rattus norvegicus 5739
-
2.3.1.137 peroxisome
-
 Rattus norvegicus 5777
-

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.3.1.137 acyl-CoA + L-carnitine Rattus norvegicus
-
 acyl-L-carnitine + CoA
-
 r
2.3.1.137 acyl-L-carnitine + CoA Rattus norvegicus
-
 acyl-CoA + L-carnitine
-
 r

Organism

EC Number Organism UniProt Comment Textmining
2.3.1.137 Rattus norvegicus
-
 rat
-

Purification (Commentary)

EC Number Purification (Comment) Organism
2.3.1.137
-
 Rattus norvegicus

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.3.1.137 liver
-
 Rattus norvegicus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.3.1.137 acyl-CoA + L-carnitine
-
 Rattus norvegicus acyl-L-carnitine + CoA
-
 r
2.3.1.137 acyl-L-carnitine + CoA
-
 Rattus norvegicus acyl-CoA + L-carnitine
-
 r
2.3.1.137 palmitoyl-CoA + L-carnitine
-
 Rattus norvegicus L-palmitoyl-L-carnitine + CoA
-
 r
2.3.1.137 palmitoyl-L-carnitine + CoA
-
 Rattus norvegicus palmitoyl-CoA + L-carnitine
-
 r

Ki Value [mM]

EC Number Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
2.3.1.137 0.0035
-
 malonyl-CoA pH 6.8 Rattus norvegicus
2.3.1.137 0.0064
-
 malonyl-CoA peroxisomal COT Rattus norvegicus
2.3.1.137 0.106
-
 malonyl-CoA pH 7.4 Rattus norvegicus