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Literature summary extracted from

  • Fitzmaurice, A.M.; Kolattukudy, P.E.
    An acyl-CoA synthase (acoas) gene adjacent to the mycocerosic acid synthase (mas) locus is necessary for mycocerosyl lipid synthesis in Mycobacterium tuberculosis var. bovis BCG (1998), J. Biol. Chem., 273, 8033-8039.
    View publication on PubMed

Cloned(Commentary)

EC Number Cloned (Comment) Organism
2.3.1.111
-
 Mycobacterium tuberculosis

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.3.1.111 eicosanoyl-CoA + 4 methylmalonyl-CoA + 8 NADPH + 8 H+ Mycobacterium tuberculosis fatty acid biosynthesis tetramethyl-branched mycocerosoyl-CoA + 4 CoA + 4 CO2 + 8 NADP+ + 4 H2O
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.3.1.111 Mycobacterium tuberculosis
-
 var. bovis Bacillus Calmette-Guerin
-

Purification (Commentary)

EC Number Purification (Comment) Organism
2.3.1.111
-
 Mycobacterium tuberculosis

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.3.1.111 eicosanoyl-CoA + 4 methylmalonyl-CoA + 8 NADPH + 8 H+
-
 Mycobacterium tuberculosis tetramethyl-branched mycocerosoyl-CoA + 4 CoA + 4 CO2 + 8 NADP+ + 4 H2O
-
 ?
2.3.1.111 eicosanoyl-CoA + 4 methylmalonyl-CoA + 8 NADPH + 8 H+ fatty acid biosynthesis Mycobacterium tuberculosis tetramethyl-branched mycocerosoyl-CoA + 4 CoA + 4 CO2 + 8 NADP+ + 4 H2O
-
 ?