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Literature summary extracted from

  • Vander Wauven, C.; Jann, A.; Haas, D.; Leisinger, T.; Stalon, V.
    N2-Succinylornithine in ornithine catabolism of Pseudomonas aeruginosa (1988), Arch. Microbiol., 150, 400-404.
    View publication on PubMed

Cloned(Commentary)

EC Number Cloned (Comment) Organism
2.3.1.109
-
 Pseudomonas aeruginosa

Protein Variants

EC Number Protein Variants Comment Organism
2.6.1.81 additional information aru mutants of strain PAO are unable to utilize L-arginine as the sole carbon and nitrogen source under aerobic conditions, while oru mutant strains are affected in ornithine utilization, oru- strains PAO968, PAO977, PAO2057, PAO958, and PAO961 show strongly reduced enzyme activity, while oru- strains PAO974, PAO957, PAO997, and PAO1007 have normal or elevated enzyme activity, overview Pseudomonas aeruginosa

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.6.1.81 aminooxoacetic acid leads to accumulation of succinyl-L-ornithine in vivo Pseudomonas aeruginosa

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
2.6.1.81 additional information
-
 additional information specific activity in several aru mutant strains Pseudomonas aeruginosa
2.6.1.81 0.42
-
 N2-succinyl-L-ornithine wild-type strain PAO1 Pseudomonas aeruginosa

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.2.1.71 additional information Pseudomonas aeruginosa fourth enzyme of the arginine succinyltransferase pathway ?
-
 ?
2.3.1.109 succinyl-CoA + L-arginine Pseudomonas aeruginosa catabolism of arginine CoA + N2-succinyl-L-arginine
-
 ?
2.3.1.109 succinyl-CoA + L-ornithine Pseudomonas aeruginosa ornithine catabolic pathway CoA + N2-succinyl-L-ornithine
-
 ?
2.6.1.81 N2-succinyl-L-ornithine + 2-oxoglutarate Pseudomonas aeruginosa step in metabolic conversion of L-arginine into L-glutamate, pathway and regulation overview N-succinyl-L-glutamate 5-semialdehyde + L-glutamate
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
1.2.1.71 Pseudomonas aeruginosa
-
-
-
2.3.1.109 Pseudomonas aeruginosa
-
-
-
2.6.1.81 Pseudomonas aeruginosa
-
 gene aruC, wild-type strain PAO1
-

Purification (Commentary)

EC Number Purification (Comment) Organism
2.3.1.109 partial Pseudomonas aeruginosa

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.2.1.71 additional information fourth enzyme of the arginine succinyltransferase pathway Pseudomonas aeruginosa ?
-
 ?
2.3.1.109 succinyl-CoA + L-arginine
-
 Pseudomonas aeruginosa CoA + N2-succinyl-L-arginine
-
 ?
2.3.1.109 succinyl-CoA + L-arginine catabolism of arginine Pseudomonas aeruginosa CoA + N2-succinyl-L-arginine
-
 ?
2.3.1.109 succinyl-CoA + L-ornithine
-
 Pseudomonas aeruginosa CoA + N2-succinyl-L-ornithine
-
 ?
2.3.1.109 succinyl-CoA + L-ornithine ornithine catabolic pathway Pseudomonas aeruginosa CoA + N2-succinyl-L-ornithine
-
 ?
2.6.1.81 N2-succinyl-L-ornithine + 2-oxoglutarate
-
 Pseudomonas aeruginosa N-succinyl-L-glutamate 5-semialdehyde + L-glutamate
-
 ?
2.6.1.81 N2-succinyl-L-ornithine + 2-oxoglutarate step in metabolic conversion of L-arginine into L-glutamate, pathway and regulation overview Pseudomonas aeruginosa N-succinyl-L-glutamate 5-semialdehyde + L-glutamate
-
 ?

Synonyms

EC Number Synonyms Comment Organism
1.2.1.71 aruD
-
 Pseudomonas aeruginosa
2.6.1.81 N2-succinylornithine 5-aminotransferase
-
 Pseudomonas aeruginosa
2.6.1.81 SOAT
-
 Pseudomonas aeruginosa
2.6.1.81 succinylornithine 5-aminotransferase
-
 Pseudomonas aeruginosa

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
2.6.1.81 37
-
 assay at Pseudomonas aeruginosa

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
2.6.1.81 7
-
 assay at Pseudomonas aeruginosa

Cofactor

EC Number Cofactor Comment Organism Structure
2.6.1.81 pyridoxal 5'-phosphate
-
 Pseudomonas aeruginosa