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Literature summary extracted from

  • Baker, R.R.; Chang, H.Y.
    MgATP inhibits the synthesis of 1-alkyl-2-acetyl-sn-glycero-3-phosphate by microsomal acetyltransferase of immature rabbit cerebral cortex (1994), Biochim. Biophys. Acta, 1213, 27-33.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
2.3.1.105 EDTA 47.8% activity in absence of both EDTA and mercaptoethanol Oryctolagus cuniculus
2.3.1.105 mercaptoethanol 47.8% activity in absence of both EDTA and mercaptoethanol Oryctolagus cuniculus
2.3.1.105 additional information activity increases in 2.4fold by preincubation with ATP, MgCl2 and high speed supernatant fractions Oryctolagus cuniculus

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.3.1.105 ADP 29% decline in subcellular fraction P3A activity, 43% decline in subcellular fraction P3B activity and 7% decline in subcellular fraction P3D activity Oryctolagus cuniculus
2.3.1.105 Alkaline phosphatase 92-95% activity lost for subcellular fractions P3A and P3B Oryctolagus cuniculus
2.3.1.105 ATP little effect on the enzyme activity for the subcellular fraction P3A, 55-64% decline in the subcellular fraction P3B Oryctolagus cuniculus
2.3.1.105 CaCl2 1 mM CaCl2 inhibits 73% and 24% activity of subcellular fractions P3B and P3D respectively Oryctolagus cuniculus
2.3.1.105 EDTA inhibits 30% fraction P3D, does not inhibit subcellular fraction P3A Oryctolagus cuniculus
2.3.1.105 MgADP- inhibitory effects less severe than MgATP Oryctolagus cuniculus
2.3.1.105 MgAMP less inhibitory effect than MgADP Oryctolagus cuniculus
2.3.1.105 MgATP2- extreme inhibition in all microsomal fractions Oryctolagus cuniculus
2.3.1.105 MgCl2 at 2 mM: 30, 28 and 58% inhibition of subcellular fractions P3A, P3B and P3D activities respectively Oryctolagus cuniculus
2.3.1.105 additional information ATP, GTP, UTP, CTP show small or no inhibition effects for fraction P3A Oryctolagus cuniculus

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
2.3.1.105 microsome
-
 Oryctolagus cuniculus
-
-

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.3.1.105 acetyl-CoA + 1-alkyl-sn-glycero-3-phosphate Oryctolagus cuniculus
-
 CoA + 1-alkyl-2-acetyl-sn-glycero-3-phosphate
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.3.1.105 Oryctolagus cuniculus
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
2.3.1.105 isolation of three subcellular fractions: P3A, P3B and P3D, using NaF, EDTA and mercaptoethanol to preserve the activity Oryctolagus cuniculus

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.3.1.105 cerebral cortex
-
 Oryctolagus cuniculus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.3.1.105 acetyl-CoA + 1-alkyl-sn-glycero-3-phosphate
-
 Oryctolagus cuniculus CoA + 1-alkyl-2-acetyl-sn-glycero-3-phosphate
-
 ?