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Literature summary extracted from

  • Pauwels, K.; Abadjieva, A.; Hilven, P.; Stankiewicz, A.; Crabeel, M.
    The N-acetylglutamate synthase/N-acetylglutamate kinase metabolon of Saccharomyces cerevisiae allows co-ordinated feedback regulation of the first two steps in arginine biosynthesis (2003), Eur. J. Biochem., 270, 1014-1024.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
2.3.1.1 additional information enzyme must interact stoichoimetrically in vivo with acetylglutamate kinase to be active Saccharomyces cerevisiae

Cloned(Commentary)

EC Number Cloned (Comment) Organism
2.3.1.1
-
 Saccharomyces cerevisiae

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.7.2.8 arginine feedback regulation of enzyme and N-acetylglutamate synthase is mutually interdependent, enzymes form a complex Saccharomyces cerevisiae

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.3.1.1 acetyl-CoA + L-glutamate Saccharomyces cerevisiae
-
 CoA + N-acetyl-L-glutamate
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.3.1.1 Saccharomyces cerevisiae
-
-
-
2.7.2.8 Saccharomyces cerevisiae
-
-
-

Reaction

EC Number Reaction Comment Organism Reaction ID
2.7.2.8 ATP + N-acetyl-L-glutamate = ADP + N-acetyl-L-glutamyl 5-phosphate enzyme has to interact stoichiometrically with acetylglutamate synthase in order to be active Saccharomyces cerevisiae
a

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.3.1.1 acetyl-CoA + L-glutamate
-
 Saccharomyces cerevisiae CoA + N-acetyl-L-glutamate
-
 ?