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Literature summary extracted from

  • Shigesada, K.; Tatibana, M.
    N-Acetylglutamate synthetase from rat-liver mitochondria. Partial purification and catalytic properties (1978), Eur. J. Biochem., 84, 285-291.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
2.3.1.1 arginine
-
Rattus norvegicus

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.3.1.1 5,5'-dithiobis(2-nitrobenzoate) strong inhibition Rattus norvegicus
2.3.1.1 AgNO3 0.1 mM, 70-90% inhibition Rattus norvegicus
2.3.1.1 BaCl2 1 mM, 30-50% inhibition Rattus norvegicus
2.3.1.1 CaCl2 1 mM, 30-50% inhibition Rattus norvegicus
2.3.1.1 CoCl2 0.1 mM, 30-50% inhibition Rattus norvegicus
2.3.1.1 coenzyme A
-
Rattus norvegicus
2.3.1.1 Cu2+ CuSO4, 0.1 mM, 70-90% inhibition Rattus norvegicus
2.3.1.1 EDTA weak inhibition Rattus norvegicus
2.3.1.1 FeCl3 0.1 mM, 30-50% inhibition Rattus norvegicus
2.3.1.1 FeSO4 0.1 mM, 30-50% inhibition Rattus norvegicus
2.3.1.1 Hg2+ Hg(CHCOO)2, 0.1 mM, 70-90% inhibition Rattus norvegicus
2.3.1.1 K2SO4
-
Rattus norvegicus
2.3.1.1 KCl 100 mM, 30% inhibition, 200 mM, 50% inhibition Rattus norvegicus
2.3.1.1 L-alpha-Acetoxylglutamate 2 mM, 17% inhibition Rattus norvegicus
2.3.1.1 MgCl2 1 mM, 30-50% inhibition Rattus norvegicus
2.3.1.1 MnCl2 0.1 mM, 30-50% inhibition Rattus norvegicus
2.3.1.1 N-acetyl-D-glutamate 2 mM, 30% inhibition Rattus norvegicus
2.3.1.1 N-acetyl-DL-alpha-aminoadipate 2 mM, 78% inhibition Rattus norvegicus
2.3.1.1 N-acetyl-L-aspartate 2 mM, 25% inhibition Rattus norvegicus
2.3.1.1 N-acetyl-L-glutamine 2 mM, 46% inhibition Rattus norvegicus
2.3.1.1 N-acetylglutamate
-
Rattus norvegicus
2.3.1.1 N-benzoyl-L-glutamate 2 mM, 29% inhibition Rattus norvegicus
2.3.1.1 N-Butyryl-L-glutamate 2 mM, 19% inhibition Rattus norvegicus
2.3.1.1 N-carbamoyl-L-glutamate 2 mM, 31% inhibition Rattus norvegicus
2.3.1.1 N-propionyl-L-glutamate 2 mM, 63% inhibition Rattus norvegicus
2.3.1.1 Ni(NO3)2 0.1 mM, 30-50% inhibition Rattus norvegicus
2.3.1.1 p-hydroxymercuribenzoate strong inhibition Rattus norvegicus
2.3.1.1 Pb(NO3)2 0.1 mM, 70-90% inhibition Rattus norvegicus
2.3.1.1 potassium phosphate
-
Rattus norvegicus
2.3.1.1 succinate 2 mM, 21% inhibition Rattus norvegicus
2.3.1.1 Zn2+ ZnCl2, 0.1 mM, 70-90% inhibition Rattus norvegicus

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
2.3.1.1 0.7
-
acetyl-CoA
-
Rattus norvegicus
2.3.1.1 3
-
L-glutamate
-
Rattus norvegicus

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
2.3.1.1 30000 300000 gel filtration, mixture of multiple forms Rattus norvegicus

Organism

EC Number Organism UniProt Comment Textmining
2.3.1.1 Rattus norvegicus
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
2.3.1.1 ammonium sulfate, hydroxyapatite, DEAE-cellulose, Sephadex G-100 Rattus norvegicus

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.3.1.1 liver
-
Rattus norvegicus
-

Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
2.3.1.1 0.012
-
-
Rattus norvegicus

Storage Stability

EC Number Storage Stability Organism
2.3.1.1 -80°C, 100 mM phosphate buffer, pH 7.5, 6 months, 50% loss of activity Rattus norvegicus
2.3.1.1 4°C, 100 mM potassium phosphate buffer, pH 7.5, 24 h, 10% loss of activity Rattus norvegicus

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.3.1.1 acetyl-CoA + glycine
-
Rattus norvegicus CoA + acetylaminoacetate
-
?
2.3.1.1 acetyl-CoA + L-glutamate
-
Rattus norvegicus CoA + N-acetyl-L-glutamate
-
?
2.3.1.1 acetyl-CoA + L-glutamine
-
Rattus norvegicus ?
-
?
2.3.1.1 benzoyl-CoA + L-glutamate very low activity Rattus norvegicus CoA + N-benzoyl-L-glutamate
-
?
2.3.1.1 butyryl-CoA + L-glutamate very low activity Rattus norvegicus CoA + N-butyryl-L-glutamate
-
?
2.3.1.1 propionyl-CoA + L-glutamate
-
Rattus norvegicus CoA + N-propionyl-L-glutamate
-
?

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
2.3.1.1 8
-
liver enzyme, in the absence of arginine Rattus norvegicus
2.3.1.1 8
-
in the absence of arginine Rattus norvegicus
2.3.1.1 8.5
-
in the presence of arginine Rattus norvegicus

Ki Value [mM]

EC Number Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
2.3.1.1 0.07
-
acetyl-glutamate
-
Rattus norvegicus