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Literature summary extracted from

  • Tricot, C.; Schmid, S.; Baur, H.; Villeret, V.; Dideberg, O.; Haas, D.; Stalon, V.
    Catabolic ornithine carbamoyltransferase of Pseudomonas aeruginosa. Changes of allosteric properties resulting from modifications at the C-terminus (1994), Eur. J. Biochem., 221, 555-561.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
2.1.3.3 AMP strong allosteric activator, 1.5 mM, half-maximal activation Pseudomonas aeruginosa
2.1.3.3 CMP strong allosteric activator Pseudomonas aeruginosa
2.1.3.3 GMP allosteric activator Pseudomonas aeruginosa
2.1.3.3 phosphate presumably via interaction with the carbamoyl phosphate-binding site Pseudomonas aeruginosa
2.1.3.3 UMP allosteric activator Pseudomonas aeruginosa

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.1.3.3 1,4-diaminobutane 10 mM; 10 mM, 45% inhibition Pseudomonas aeruginosa
2.1.3.3 spermidine 10 mM, 93% inhibition, 3.7 mM, 50% inhibition Pseudomonas aeruginosa

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
2.1.3.3 38000
-
 12 * 38000, SDS-PAGE Pseudomonas aeruginosa
2.1.3.3 420000
-
 gel filtration Pseudomonas aeruginosa

Organism

EC Number Organism UniProt Comment Textmining
2.1.3.3 Pseudomonas aeruginosa
-
 catabolic ornithine carbamoyltransferase
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.1.3.3 carbamoyl phosphate + L-ornithine catabolic ornithine carbamoyltransferase, catalyzes the reverse reaction, i.e. the cleavage of citrulline Pseudomonas aeruginosa phosphate + L-citrulline
-
 ?

Subunits

EC Number Subunits Comment Organism
2.1.3.3 dodecamer 12 * 38000, SDS-PAGE Pseudomonas aeruginosa

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
2.1.3.3 7.2
-
 at 10 mM carbamoyl phosphate, sharp decrease of activity above Pseudomonas aeruginosa

pH Range

EC Number pH Minimum pH Maximum Comment Organism
2.1.3.3 6 7.2 at 10 mM carbamoyl phosphate, sharp decrease in activity above Pseudomonas aeruginosa