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Literature summary extracted from

  • Abdelal, A.T.H.; Kennedy, E.H.; Nainan, O.
    Ornithine transcarbamylase from Salmonella typhimurium: purification, subunit composition, kinetic analysis, and immunological cross-reactivity (1977), J. Bacteriol., 129, 1387-1396.
    View publication on PubMedView publication on EuropePMC

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.1.3.3 arginine 5 mM, 42% inhibition Salmonella enterica subsp. enterica serovar Typhimurium

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
2.1.3.3 39000
-
 3 * 39000, SDS-PAGE Salmonella enterica subsp. enterica serovar Typhimurium
2.1.3.3 116000
-
 sucrose density gradient ultracentrifugation Salmonella enterica subsp. enterica serovar Typhimurium

Organism

EC Number Organism UniProt Comment Textmining
2.1.3.3 Pisum sativum
-
-
-
2.1.3.3 Salmonella enterica subsp. enterica serovar Typhimurium
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
2.1.3.3 protamine sulfate, ammonium sulfate, diethylaminoethyl-cellulose, Sephadex G-150, hydroxylapatite Salmonella enterica subsp. enterica serovar Typhimurium

Reaction

EC Number Reaction Comment Organism Reaction ID
2.1.3.3 carbamoyl phosphate + L-ornithine = phosphate + L-citrulline mechanism Salmonella enterica subsp. enterica serovar Typhimurium
a

Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
2.1.3.3 1901
-
-
 Salmonella enterica subsp. enterica serovar Typhimurium

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.1.3.3 carbamoyl phosphate + L-ornithine
-
 Salmonella enterica subsp. enterica serovar Typhimurium phosphate + L-citrulline
-
 ?
2.1.3.3 carbamoyl phosphate + L-ornithine
-
 Pisum sativum phosphate + L-citrulline
-
 ?

Subunits

EC Number Subunits Comment Organism
2.1.3.3 trimer
-
 Pisum sativum
2.1.3.3 trimer 3 * 39000, SDS-PAGE Salmonella enterica subsp. enterica serovar Typhimurium

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
2.1.3.3 8
-
-
 Salmonella enterica subsp. enterica serovar Typhimurium
2.1.3.3 8
-
-
 Pisum sativum

pH Range

EC Number pH Minimum pH Maximum Comment Organism
2.1.3.3 7 9 50% of maximal activity at pH 9.0, 70% at pH 7.0 Salmonella enterica subsp. enterica serovar Typhimurium