Literature summary extracted from

Laing, N.; Chan, W.W.C.; Hutchinson, D.W.; �berg, B.
Phosphorus-containing inhibitors of aspartate transcarbamoylase from Escherichia coli (1990), FEBS Lett., 260, 206-208.

Inhibitors

EC Number	Inhibitors	Comment	Organism	Structure
2.1.3.2	Carbonyldiphosphonate	-	Escherichia coli
2.1.3.2	dichlormethylenediphosphonate	-	Escherichia coli
2.1.3.2	diphosphate	-	Escherichia coli
2.1.3.2	Diphosphate analogues	-	Escherichia coli
2.1.3.2	hypophosphate	-	Escherichia coli
2.1.3.2	imidodiphosphonate	-	Escherichia coli
2.1.3.2	Methylenediphosphonate	-	Escherichia coli
2.1.3.2	N-(Phosphonoacetyl)-L-aspartate	-	Escherichia coli
2.1.3.2	N-Diphosphoryl-L-aspartate	-	Escherichia coli
2.1.3.2	N-phosphoryl-L-aspartate	-	Escherichia coli
2.1.3.2	N-pyrophosphoryl-L-aspartate	-	Escherichia coli
2.1.3.2	O-phosphonoacetyl-oxosuccinate	-	Escherichia coli
2.1.3.2	Phosphonoacetate	-	Escherichia coli
2.1.3.2	Phosphonoformate	-	Escherichia coli
2.1.3.2	phosphonopropionate	-	Escherichia coli
2.1.3.2	S-diphosphoryl-mercaptosuccinate	-	Escherichia coli
2.1.3.2	S-phosphonoacetyl-mercaptosuccinate	-	Escherichia coli

Natural Substrates/ Products (Substrates)

EC Number	Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
2.1.3.2	carbamoylphosphate + L-aspartate	Escherichia coli	-	phosphate + N-carbamoyl-L-aspartate	-	?

Organism

EC Number	Organism	UniProt	Comment	Textmining
2.1.3.2	Escherichia coli	-	-	-

Reaction

EC Number	Reaction	Comment	Organism	Reaction ID
2.1.3.2	carbamoyl phosphate + L-aspartate = phosphate + N-carbamoyl-L-aspartate	reaction proceeds via a nucleophilic attack by the free amino group of L-aspartate on the carbon of carbamoylphosphate	Escherichia coli	a

Substrates and Products (Substrate)

EC Number	Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
2.1.3.2	carbamoyl phosphate + L-aspartate	-	Escherichia coli	phosphate + N-carbamoyl-L-aspartate	-	?
2.1.3.2	carbamoylphosphate + L-aspartate	-	Escherichia coli	phosphate + N-carbamoyl-L-aspartate	-	?

Ki Value [mM]

EC Number	Ki Value [mM]	Ki Value maximum [mM]	Inhibitor	Comment	Organism	Structure
2.1.3.2	0.000027	-	N-(phosphonacetyl)-L-aspartate	-	Escherichia coli
2.1.3.2	0.00024	-	N-pyrophosphoryl-L-aspartate	-	Escherichia coli
2.1.3.2	0.002	-	O-phosphonoacetyl-oxosuccinate	-	Escherichia coli
2.1.3.2	0.0035	-	Carbonyldiphosphonate	-	Escherichia coli
2.1.3.2	0.0055	-	S-phosphonoacetyl-mercaptosuccinate	-	Escherichia coli
2.1.3.2	0.017	-	S-diphosphoryl-mercaptosuccinate	-	Escherichia coli
2.1.3.2	0.02	-	hypophosphate	-	Escherichia coli
2.1.3.2	0.022	-	Phosphonoformate	-	Escherichia coli
2.1.3.2	0.032	-	dichlormethylenediphosphonate	-	Escherichia coli
2.1.3.2	0.037	-	Methylenediphosphonate	-	Escherichia coli
2.1.3.2	0.05	-	N-phosphoryl-L-aspartate	-	Escherichia coli
2.1.3.2	0.051	-	diphosphate	-	Escherichia coli
2.1.3.2	0.071	-	imidodiphosphonate	-	Escherichia coli
2.1.3.2	0.15	-	Phosphonoacetate	-	Escherichia coli
2.1.3.2	0.175	-	peroxydiphosphonate	-	Escherichia coli
2.1.3.2	2	-	ethylamidocarbonylphosphonate	-	Escherichia coli
2.1.3.2	7.5	-	3-phosphonopropanoic acid	-	Escherichia coli

Use of this online version of BRENDA is free under the CC BY 4.0 license. See terms of use for full details.

Release 2023.1 (January 2023)