Literature summary extracted from

Wilson, E.M.; Snell, E.E.
Metabolism of alpha-methylserine. II. Stereospecificity of alpha-methylserine hydroxymethyltransferase (1962), J. Biol. Chem., 237, 3180-3184.

Organism

EC Number	Organism	UniProt	Comment	Textmining
2.1.2.7	Pseudomonas sp.	-	-	-

Substrates and Products (Substrate)

EC Number	Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
2.1.2.7	tetrahydrofolate + (+)-2-methylserine	stereospecific, dimedon cannot replace tetrahydrofolate	Pseudomonas sp.	5,10-methylenetetrahydrofolate + D-alanine + H2O	-	r
2.1.2.7	tetrahydrofolate + (-)-ethylserine	stereospecific	Pseudomonas sp.	5,10-methylenetetrahydrofolate + D-2-aminobutyrate + H2O	-	r
2.1.2.7	tetrahydrofolate + 2-hydroxymethylserine	specific removal of one of the two hydroxyl groups	Pseudomonas sp.	5,10-methylenetetrahydrofolate + D-serine + H2O	-	r

Cofactor

EC Number	Cofactor	Comment	Organism	Structure
2.1.2.7	pyridoxal 5'-phosphate	requirement	Pseudomonas sp.

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Release 2023.1 (January 2023)