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Literature summary extracted from

  • Wall, M.; Shim, J.H.; Benkovic, S.J.
    Human AICAR transformylase: Role of the 4-Carboxamide of AICAR in binding and catalysis (2000), Biochemistry, 39, 11303-11311.
    View publication on PubMed

Application

EC Number Application Comment Organism
2.1.2.3 medicine target for development of inhibitors with potential use as chemotherapeutic agents Homo sapiens

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.1.2.3 4-N-allyl-5-aminoimidazole-4-carboxamide ribonucleotide
-
 Homo sapiens
2.1.2.3 4-N-methyl-5-aminoimidazole-4-carboxamide ribonucleotide
-
 Homo sapiens
2.1.2.3 5'-phosphoribosyl-5-formamido-4-imidazolecarboxamide product inhibitor Homo sapiens
2.1.2.3 5-amino-1-beta-D-ribofuranosylimidazole 5'-phosphate
-
 Homo sapiens
2.1.2.3 5-amino-1-beta-D-ribofuranosylimidazole-4-carbonitrile 5'-phosphate
-
 Homo sapiens
2.1.2.3 5-amino-1-beta-D-ribofuranosylimidazole-4-carboxamidoxime 5'-phosphate
-
 Homo sapiens
2.1.2.3 5-amino-1-beta-D-ribofuranosylimidazole-4-carboxylate 5'-phosphate
-
 Homo sapiens
2.1.2.3 5-amino-4-nitro-1-beta-D-ribofuranosylimidazole 5'-phosphate
-
 Homo sapiens
2.1.2.3 5-formyl-5-aminoimidazole-4-carboxamide ribonucleotide
-
 Homo sapiens
2.1.2.3 AMP
-
 Homo sapiens
2.1.2.3 XMP
-
 Homo sapiens

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
2.1.2.3 0.0009
-
 5-amino-imidazole-4-thiocarboxamide ribonucleotide 10-formyldihydrofolate as cofactor Homo sapiens
2.1.2.3 0.0015
-
 5-aminoimidazole-4-carboxamide ribonucleotide 10-formyldihydrofolate as cofactor Homo sapiens
2.1.2.3 0.0019
-
 5-aminoimidazole-4-carboxamide ribonucleotide 10-formyltetrahydrofolate as cofactor Homo sapiens
2.1.2.3 0.01
-
 5-aminoimidazole-4-carboxamide ribonucleotide
-
 Homo sapiens

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.1.2.3 10-formyltetrahydrofolate + 5'-phosphoribosyl-5-amino-imidazolecarboxamide Escherichia coli
-
 tetrahdrofolic acid + 5'-phosphoribosyl-5-formamido-4-imidazolecarboxamide
-
 r
2.1.2.3 10-formyltetrahydrofolate + 5'-phosphoribosyl-5-amino-imidazolecarboxamide Homo sapiens
-
 tetrahdrofolic acid + 5'-phosphoribosyl-5-formamido-4-imidazolecarboxamide
-
 r

Organism

EC Number Organism UniProt Comment Textmining
2.1.2.3 Escherichia coli
-
-
-
2.1.2.3 Homo sapiens
-
 human
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.1.2.3 10-formyltetrahydrofolate + 5'-phosphoribosyl-5-amino-imidazolecarboxamide
-
 Escherichia coli tetrahdrofolic acid + 5'-phosphoribosyl-5-formamido-4-imidazolecarboxamide
-
 r
2.1.2.3 10-formyltetrahydrofolate + 5'-phosphoribosyl-5-amino-imidazolecarboxamide
-
 Homo sapiens tetrahdrofolic acid + 5'-phosphoribosyl-5-formamido-4-imidazolecarboxamide
-
 r
2.1.2.3 10-formyltetrahydrofolate + 5-amino-imidazole-4-thiocarboxamide ribonucleotide
-
 Homo sapiens tetrahydrofolate + 6-mercaptopurine ribonucleotide
-
 ?
2.1.2.3 additional information in all organisms studied to date AICARFT activity is accompanied by inosine monophosphate cyclohydrolase located on the same polypeptide encoded by the purH gene Escherichia coli ?
-
 ?
2.1.2.3 additional information in all organisms studied to date AICARFT activity is accompanied by inosine monophosphate cyclohydrolase located on the same polypeptide encoded by the purH gene Homo sapiens ?
-
 ?
2.1.2.3 N10-formyltetrahydrofolic acid + 5-amino-4-imidazole carboxamide ribonucleotide
-
 Escherichia coli tetrahydrofolic acid + 5-formamido-4-imidazole carboxamide ribonucleotide
-
 r
2.1.2.3 N10-formyltetrahydrofolic acid + 5-amino-4-imidazole carboxamide ribonucleotide
-
 Homo sapiens tetrahydrofolic acid + 5-formamido-4-imidazole carboxamide ribonucleotide
-
 r

Cofactor

EC Number Cofactor Comment Organism Structure
2.1.2.3 10-formyldihydrofolate
-
 Homo sapiens
2.1.2.3 10-formylfolate
-
 Homo sapiens
2.1.2.3 N10-formyltetrahydrofolate
-
 Homo sapiens

Ki Value [mM]

EC Number Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
2.1.2.3 0.0004
-
 5-formyl-5-aminoimidazole-4-carboxamide ribonucleotide
-
 Homo sapiens
2.1.2.3 0.0007
-
 5-amino-4-nitroimidazole ribonucleotide
-
 Homo sapiens
2.1.2.3 0.0007
-
 5-amino-4-nitro-1-beta-D-ribofuranosylimidazole 5'-phosphate
-
 Homo sapiens
2.1.2.3 0.0012
-
 XMP
-
 Homo sapiens
2.1.2.3 0.006
-
 5-amino-1-beta-D-ribofuranosylimidazole 5'-phosphate
-
 Homo sapiens
2.1.2.3 0.01
-
 5-amino-1-beta-D-ribofuranosylimidazole-4-carboxylate 5'-phosphate
-
 Homo sapiens
2.1.2.3 0.026
-
 5-amino-1-beta-D-ribofuranosylimidazole-4-carbonitrile 5'-phosphate
-
 Homo sapiens
2.1.2.3 0.027
-
 AMP
-
 Homo sapiens