Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary extracted from

  • Baggott, J.E.; Vaughn, W.H.; Hudson, B.B.
    Inhibition of 5-aminoimidazole-4-carboxamide ribotide transformylase, adenosine deaminase and 5'-adenylate deaminase by polyglutamates of methotrexate and oxidized folates and by 5-aminoimidazole-4-carboxamide riboside and ribotide (1986), Biochem. J., 236, 193-200.
    View publication on PubMedView publication on EuropePMC

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.1.2.3 10-formyl-5,6,7,8-tetrahydropteroylpenta-gamma-glutamate
-
 Gallus sp.
2.1.2.3 10-formylfolic acid pentaglutamate competitive inhibitor Gallus sp.
2.1.2.3 4-amino-10-methylpteroyl-gamma-glutamyl-gamma-glutamyl-gamma-glutamylglutamic acid methotrexate polyglutamate, competitive inhibitor Gallus sp.
2.1.2.3 4-amino-10-methylpteroylglutamic acid methotrexate, non-competitive inhibitor Gallus sp.
2.1.2.3 5-amino-4-nitroimidazole ribonucleotide
-
 Mus musculus
2.1.2.3 5-formyl-5-aminoimidazole-4-carboxamide ribonucleotide
-
 Mus musculus
2.1.2.3 7,8-dihydropteroylpenta-gamma-glutamate
-
 Gallus sp.
2.1.2.3 dihydrofolic acid pentaglutamate
-
 Gallus sp.
2.1.2.3 folic acid pentaglutamate competitive inhibitor Gallus sp.
2.1.2.3 methotrexate
-
 Gallus sp.
2.1.2.3 pteroylpenta-gamma-glutamate
-
 Gallus sp.

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
2.1.2.3 0.00023
-
 tetrahydrofolic acid
-
 Gallus sp.
2.1.2.3 0.00051
-
 10-formyldihydrofolic acid pentaglutamate
-
 Gallus sp.

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.1.2.3 10-formyltetrahydrofolate + 5'-phosphoribosyl-5-amino-imidazolecarboxamide Mus musculus
-
 tetrahdrofolic acid + 5'-phosphoribosyl-5-formamido-4-imidazolecarboxamide
-
 r
2.1.2.3 10-formyltetrahydrofolate + 5'-phosphoribosyl-5-amino-imidazolecarboxamide Gallus sp.
-
 tetrahdrofolic acid + 5'-phosphoribosyl-5-formamido-4-imidazolecarboxamide
-
 r

Organism

EC Number Organism UniProt Comment Textmining
2.1.2.3 Gallus sp.
-
 chicken
-
2.1.2.3 Mus musculus
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
2.1.2.3 partially Gallus sp.

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.1.2.3 Ehrlich ascites carcinoma cell
-
 Mus musculus
-
2.1.2.3 liver
-
 Gallus sp.
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.1.2.3 10-formyl-7,8-dihydropteroylpenta-gamma-glutamate + 5'-phosphoribosyl-5-amino-4-imidazolecarboxamide
-
 Gallus sp. 7,8-dihydropteroylpenta-gamma-glutarate + 5'-phosphoribosyl-5-formamido-4-imidazolecarboxamide
-
 ?
2.1.2.3 10-formyl-7,8-dihydropteroylpenta-gamma-L-glutamate + 5'-phosphoribosyl-5-amino-4-imidazolecarboxamide
-
 Gallus sp. dihydrofolic acid pentaglutamate + 5'-phosphoribosyl-5-formamido-4-imidazolecarboxamide
-
 ?
2.1.2.3 10-formyldihydrofolic acid pentaglutamate + 5-aminoimidazole-4-carboxamide
-
 Gallus sp. ?
-
 r
2.1.2.3 10-formyltetrahydrofolate + 5'-phosphoribosyl-5-amino-imidazolecarboxamide
-
 Mus musculus tetrahdrofolic acid + 5'-phosphoribosyl-5-formamido-4-imidazolecarboxamide
-
 r
2.1.2.3 10-formyltetrahydrofolate + 5'-phosphoribosyl-5-amino-imidazolecarboxamide
-
 Gallus sp. tetrahdrofolic acid + 5'-phosphoribosyl-5-formamido-4-imidazolecarboxamide
-
 r
2.1.2.3 additional information in all organisms studied to date AICARFT activity is accompanied by inosine monophosphate cyclohydrolase located on the same polypeptide encoded by the purH gene Mus musculus ?
-
 ?
2.1.2.3 additional information in all organisms studied to date AICARFT activity is accompanied by inosine monophosphate cyclohydrolase located on the same polypeptide encoded by the purH gene Gallus sp. ?
-
 ?
2.1.2.3 N10-formyltetrahydrofolic acid + 5-amino-4-imidazole carboxamide ribonucleotide
-
 Mus musculus tetrahydrofolic acid + 5-formamido-4-imidazole carboxamide ribonucleotide
-
 r
2.1.2.3 N10-formyltetrahydrofolic acid + 5-amino-4-imidazole carboxamide ribonucleotide
-
 Gallus sp. tetrahydrofolic acid + 5-formamido-4-imidazole carboxamide ribonucleotide
-
 r

Ki Value [mM]

EC Number Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
2.1.2.3 0.00004
-
 5-amino-4-nitroimidazole ribonucleotide
-
 Mus musculus
2.1.2.3 0.00007
-
 5-formyl-5-aminoimidazole-4-carboxamide ribonucleotide
-
 Mus musculus
2.1.2.3 0.00008
-
 folic acid pentaglutamate
-
 Gallus sp.
2.1.2.3 0.00014
-
 dihydrofolic acid pentaglutamate
-
 Gallus sp.
2.1.2.3 0.00137
-
 10-formylfolic acid pentaglutamate
-
 Gallus sp.
2.1.2.3 0.00315
-
 methotrexate polyglutamate
-
 Gallus sp.
2.1.2.3 0.075
-
 methotrexate
-
 Gallus sp.