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Literature summary extracted from

  • Baigori, M.; Grau, R.; Morbidoni, H.R.; de Mendoza, D.
    Isolation and characterization of Bacillus subtilis mutants blocked in the synthesis of pantothenic acid (1991), J. Bacteriol., 173, 4240-4242.
    View publication on PubMedView publication on EuropePMC

Cloned(Commentary)

EC Number Cloned (Comment) Organism
2.1.2.11 panB gene coding for enzyme is located together with panE in the intervall purE-tre of the chromosome Bacillus subtilis

Protein Variants

EC Number Protein Variants Comment Organism
2.1.2.11 additional information panB mutant strain UR2 is severely deficient in enzyme, a single mutation is responsible for the lack of transferase Bacillus subtilis

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.1.2.11 5,10-methylenetetrahydrofolate + 3-methyl-2-oxobutanoate Bacillus subtilis biosynthesis of pantothenate tetrahydrofolate + 2-dehydropantoate
-
?

Organism

EC Number Organism UniProt Comment Textmining
2.1.2.11 Bacillus subtilis
-
strains 168, BD170, UR1, UR4
-

Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
2.1.2.11 0.0025
-
strain BD170 Bacillus subtilis
2.1.2.11 0.00254
-
strain UR1 Bacillus subtilis
2.1.2.11 0.00258
-
strain UR4 Bacillus subtilis
2.1.2.11 0.00262
-
strain 168 Bacillus subtilis

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.1.2.11 5,10-methylenetetrahydrofolate + 3-methyl-2-oxobutanoate
-
Bacillus subtilis tetrahydrofolate + 2-dehydropantoate
-
?
2.1.2.11 5,10-methylenetetrahydrofolate + 3-methyl-2-oxobutanoate biosynthesis of pantothenate Bacillus subtilis tetrahydrofolate + 2-dehydropantoate
-
?

Cofactor

EC Number Cofactor Comment Organism Structure
2.1.2.11 5,10-methylenetetrahydrofolate
-
Bacillus subtilis
2.1.2.11 tetrahydrofolate
-
Bacillus subtilis