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Literature summary extracted from

  • Wightman, R.H.
    Stereochemistry of 2-oxopantoate formation by oxopantoate hydroxymethyltransferase (1979), J. Chem. Soc. Chem. Commun., 1979, 818-819.
No PubMed abstract available

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.1.2.11 5,10-methylenetetrahydrofolate + 3-methyl-2-oxobutanoate Escherichia coli biosynthesis of coenzyme A tetrahydrofolate + 2-dehydropantoate
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?

Organism

EC Number Organism UniProt Comment Textmining
2.1.2.11 Escherichia coli
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-
-

Reaction

EC Number Reaction Comment Organism Reaction ID
2.1.2.11 5,10-methylenetetrahydrofolate + 3-methyl-2-oxobutanoate + H2O = tetrahydrofolate + 2-dehydropantoate stereochemistry Escherichia coli
2.1.2.11 5,10-methylenetetrahydrofolate + 3-methyl-2-oxobutanoate + H2O = tetrahydrofolate + 2-dehydropantoate class II aldolase Escherichia coli

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.1.2.11 5,10-methylenetetrahydrofolate + 3-methyl-2-oxobutanoate forms 2-oxopantoate, syn. 3-hydroxymethyl-3-methyl-2-oxobutanoic acid, from 2-oxoisovalerate with retention of configuration at C-3 Escherichia coli tetrahydrofolate + 2-dehydropantoate
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?
2.1.2.11 5,10-methylenetetrahydrofolate + 3-methyl-2-oxobutanoate biosynthesis of coenzyme A Escherichia coli tetrahydrofolate + 2-dehydropantoate
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?

Cofactor

EC Number Cofactor Comment Organism Structure
2.1.2.11 5,10-methylenetetrahydrofolate
-
Escherichia coli
2.1.2.11 tetrahydrofolate
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Escherichia coli