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Literature summary extracted from

  • Ingrosso, D.; Kagan, R.M.; Clarke, S.
    Distinct C-terminal sequences of isozymes I and II of the human erythrocyte L-isoaspartyl/D-aspartyl protein methyltransferase [published erratum appears in Biochem Biophys Res Commun 1991 Apr 15;176(1):549] (1991), Biochem. Biophys. Res. Commun., 175, 351-358.
    View publication on PubMed

Cloned(Commentary)

EC Number Cloned (Comment) Organism
2.1.1.77 sequence analysis of a cDNA clone of a rat brain enzyme Rattus norvegicus
2.1.1.77 southern blot analysis of PCR amplified genomic DNA, human chromosome contains a single gene encoding the enzyme, PCMT1, mapped to the q24-25 region of chromosome 6 Homo sapiens

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
2.1.1.77 24630
-
 amino acid sequence Rattus norvegicus
2.1.1.77 25000
-
-
 Homo sapiens
2.1.1.77 25000
-
-
 Rattus norvegicus

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.1.1.77 S-adenosyl-L-methionine + protein L-isoaspartate Salmonella enterica subsp. enterica serovar Typhimurium
-
 S-adenosyl-L-homocysteine + protein L-isoaspartate alpha-methyl ester
-
 ?
2.1.1.77 S-adenosyl-L-methionine + protein L-isoaspartate Drosophila melanogaster
-
 S-adenosyl-L-homocysteine + protein L-isoaspartate alpha-methyl ester
-
 ?
2.1.1.77 S-adenosyl-L-methionine + protein L-isoaspartate Mus musculus
-
 S-adenosyl-L-homocysteine + protein L-isoaspartate alpha-methyl ester
-
 ?
2.1.1.77 S-adenosyl-L-methionine + protein L-isoaspartate Escherichia coli
-
 S-adenosyl-L-homocysteine + protein L-isoaspartate alpha-methyl ester
-
 ?
2.1.1.77 S-adenosyl-L-methionine + protein L-isoaspartate Homo sapiens
-
 S-adenosyl-L-homocysteine + protein L-isoaspartate alpha-methyl ester
-
 ?
2.1.1.77 S-adenosyl-L-methionine + protein L-isoaspartate Rattus norvegicus
-
 S-adenosyl-L-homocysteine + protein L-isoaspartate alpha-methyl ester
-
 ?
2.1.1.77 S-adenosyl-L-methionine + protein L-isoaspartate Bos taurus
-
 S-adenosyl-L-homocysteine + protein L-isoaspartate alpha-methyl ester
-
 ?
2.1.1.77 S-adenosyl-L-methionine + protein L-isoaspartate Oryctolagus cuniculus
-
 S-adenosyl-L-homocysteine + protein L-isoaspartate alpha-methyl ester
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.1.1.77 Bos taurus
-
 bovine
-
2.1.1.77 Drosophila melanogaster
-
-
-
2.1.1.77 Escherichia coli
-
-
-
2.1.1.77 Homo sapiens
-
 human
-
2.1.1.77 Mus musculus
-
-
-
2.1.1.77 Oryctolagus cuniculus
-
 rabbit
-
2.1.1.77 Rattus norvegicus
-
-
-
2.1.1.77 Salmonella enterica subsp. enterica serovar Typhimurium
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
2.1.1.77
-
 Homo sapiens

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.1.1.77 brain
-
 Mus musculus
-
2.1.1.77 brain
-
 Homo sapiens
-
2.1.1.77 brain
-
 Rattus norvegicus
-
2.1.1.77 brain
-
 Bos taurus
-
2.1.1.77 brain
-
 Oryctolagus cuniculus
-
2.1.1.77 erythrocyte
-
 Mus musculus
-
2.1.1.77 erythrocyte
-
 Homo sapiens
-
2.1.1.77 erythrocyte
-
 Rattus norvegicus
-
2.1.1.77 erythrocyte
-
 Bos taurus
-
2.1.1.77 heart
-
 Mus musculus
-
2.1.1.77 heart
-
 Oryctolagus cuniculus
-
2.1.1.77 liver
-
 Mus musculus
-
2.1.1.77 liver
-
 Rattus norvegicus
-
2.1.1.77 liver
-
 Oryctolagus cuniculus
-
2.1.1.77 muscle
-
 Oryctolagus cuniculus
-
2.1.1.77 placenta
-
 Homo sapiens
-
2.1.1.77 testis
-
 Mus musculus
-
2.1.1.77 testis
-
 Rattus norvegicus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.1.1.77 S-adenosyl-L-methionine + protein D-aspartate
-
 Escherichia coli S-adenosyl-L-homocysteine + protein D-aspartate beta-methyl ester
-
 ?
2.1.1.77 S-adenosyl-L-methionine + protein D-aspartate
-
 Homo sapiens S-adenosyl-L-homocysteine + protein D-aspartate beta-methyl ester
-
 ?
2.1.1.77 S-adenosyl-L-methionine + protein D-aspartate
-
 Bos taurus S-adenosyl-L-homocysteine + protein D-aspartate beta-methyl ester
-
 ?
2.1.1.77 S-adenosyl-L-methionine + protein L-isoaspartate
-
 Salmonella enterica subsp. enterica serovar Typhimurium S-adenosyl-L-homocysteine + protein L-isoaspartate alpha-methyl ester
-
 ?
2.1.1.77 S-adenosyl-L-methionine + protein L-isoaspartate
-
 Drosophila melanogaster S-adenosyl-L-homocysteine + protein L-isoaspartate alpha-methyl ester
-
 ?
2.1.1.77 S-adenosyl-L-methionine + protein L-isoaspartate
-
 Mus musculus S-adenosyl-L-homocysteine + protein L-isoaspartate alpha-methyl ester
-
 ?
2.1.1.77 S-adenosyl-L-methionine + protein L-isoaspartate
-
 Escherichia coli S-adenosyl-L-homocysteine + protein L-isoaspartate alpha-methyl ester
-
 ?
2.1.1.77 S-adenosyl-L-methionine + protein L-isoaspartate
-
 Homo sapiens S-adenosyl-L-homocysteine + protein L-isoaspartate alpha-methyl ester
-
 ?
2.1.1.77 S-adenosyl-L-methionine + protein L-isoaspartate
-
 Rattus norvegicus S-adenosyl-L-homocysteine + protein L-isoaspartate alpha-methyl ester
-
 ?
2.1.1.77 S-adenosyl-L-methionine + protein L-isoaspartate
-
 Bos taurus S-adenosyl-L-homocysteine + protein L-isoaspartate alpha-methyl ester
-
 ?
2.1.1.77 S-adenosyl-L-methionine + protein L-isoaspartate
-
 Oryctolagus cuniculus S-adenosyl-L-homocysteine + protein L-isoaspartate alpha-methyl ester
-
 ?

Subunits

EC Number Subunits Comment Organism
2.1.1.77 monomer
-
 Escherichia coli
2.1.1.77 monomer
-
 Bos taurus
2.1.1.77 monomer 1 + 25000 Homo sapiens

Synonyms

EC Number Synonyms Comment Organism
2.1.1.77 protein carboxyl methyltransferase type II
-
 Homo sapiens