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Literature summary extracted from

  • Fessing, M.Y.; Belkov, V.M.; Krynetski, E.Y.; Evans, W.E.
    Molecular cloning and functional characterization of the cDNA encoding the murine thiopurine S-methyltransferase (TPMT) (1998), FEBS Lett., 424, 143-145.
    View publication on PubMed

Application

EC Number Application Comment Organism
2.1.1.67 medicine
-
 Homo sapiens

Cloned(Commentary)

EC Number Cloned (Comment) Organism
2.1.1.67 cDNA cloned and heterologous expressed in rabbit reticulocytes and wheat germ lysate Mus musculus

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
2.1.1.67 cytoplasm
-
 Homo sapiens 5737
-
2.1.1.67 cytoplasm
-
 Mus musculus 5737
-
2.1.1.67 cytosol
-
 Homo sapiens 5829
-
2.1.1.67 cytosol
-
 Mus musculus 5829
-

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
2.1.1.67 28000
-
-
 Homo sapiens

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.1.1.67 S-adenosyl-L-methionine + a thiopurine Homo sapiens
-
 S-adenosyl-L-homocysteine + a thiopurine S-methylether
-
 ?
2.1.1.67 S-adenosyl-L-methionine + a thiopurine Mus musculus
-
 S-adenosyl-L-homocysteine + a thiopurine S-methylether
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.1.1.67 Homo sapiens
-
 human
-
2.1.1.67 Mus musculus O55060 mouse
-
2.1.1.67 Mus musculus O55060 mouse, strain C57/BL6, GenBank accession number
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.1.1.67 blood
-
 Homo sapiens
-
2.1.1.67 erythrocyte
-
 Homo sapiens
-
2.1.1.67 kidney
-
 Homo sapiens
-
2.1.1.67 kidney
-
 Mus musculus
-
2.1.1.67 liver
-
 Homo sapiens
-
2.1.1.67 liver
-
 Mus musculus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.1.1.67 S-adenosyl-L-methionine + 6-mercaptopurine
-
 Homo sapiens S-adenosyl-L-homocysteine + 6-methylmercaptopurine
-
 ?
2.1.1.67 S-adenosyl-L-methionine + 6-mercaptopurine
-
 Mus musculus S-adenosyl-L-homocysteine + 6-methylmercaptopurine
-
 ?
2.1.1.67 S-adenosyl-L-methionine + 6-thioguanine
-
 Homo sapiens S-adenosyl-L-homocysteine + 6-methylthioguanine
-
 ?
2.1.1.67 S-adenosyl-L-methionine + 6-thioguanine
-
 Mus musculus S-adenosyl-L-homocysteine + 6-methylthioguanine
-
 ?
2.1.1.67 S-adenosyl-L-methionine + a thiopurine
-
 Homo sapiens S-adenosyl-L-homocysteine + a thiopurine S-methylether
-
 ?
2.1.1.67 S-adenosyl-L-methionine + a thiopurine
-
 Mus musculus S-adenosyl-L-homocysteine + a thiopurine S-methylether
-
 ?