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Literature summary extracted from
- Human thiopurine methyltransferase: no evidence of activation by its substrates (1997), Life Sci., 62, 343-350.
Application
| EC Number | Application | Comment | Organism |
|---|---|---|---|
| 2.1.1.67 | medicine | - |
Homo sapiens |
Cloned(Commentary)
| EC Number | Cloned (Comment) | Organism |
|---|---|---|
| 2.1.1.67 | baculovirus expressed | Homo sapiens |
Inhibitors
| EC Number | Inhibitors | Comment | Organism | Structure |
|---|---|---|---|---|
| 2.1.1.67 | 2,8-dihydroxy-6-mercaptopurine | - |
Homo sapiens |  |
| 2.1.1.67 | 2-Hydroxy-6-mercaptopurine | - |
Homo sapiens | |
| 2.1.1.67 | 6-thioguanine | mixed inhibitor of 6-mercaptopurine methylation | Homo sapiens | |
KM Value [mM]
| EC Number | KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|---|
| 2.1.1.67 | 0.38 | - |
6-Mercaptopurine | kidney enzyme | Homo sapiens | |
| 2.1.1.67 | 0.58 | - |
6-Mercaptopurine | liver enzyme | Homo sapiens | |
| 2.1.1.67 | 0.99 | - |
6-Mercaptopurine | recombinant enzyme, baculovirus expressed | Homo sapiens | |
Localization
| EC Number | Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|---|
| 2.1.1.67 | cytosol | - |
Homo sapiens | 5829 | - |
Natural Substrates/ Products (Substrates)
| EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 2.1.1.67 | S-adenosyl-L-methionine + a thiopurine | Homo sapiens | - |
S-adenosyl-L-homocysteine + a thiopurine S-methylether | - |
? | |
Organism
| EC Number | Organism | UniProt | Comment | Textmining |
|---|---|---|---|---|
| 2.1.1.67 | Homo sapiens | - |
human | - |
Source Tissue
| EC Number | Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|---|
| 2.1.1.67 | erythrocyte | - |
Homo sapiens | - |
Substrates and Products (Substrate)
| EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 2.1.1.67 | S-adenosyl-L-methionine + 6-mercaptopurine | - |
Homo sapiens | S-adenosyl-L-homocysteine + 6-methylmercaptopurine | - |
? | |
| 2.1.1.67 | S-adenosyl-L-methionine + a thiopurine | - |
Homo sapiens | S-adenosyl-L-homocysteine + a thiopurine S-methylether | - |
? | |
Ki Value [mM]
| EC Number | Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
|---|---|---|---|---|---|---|
| 2.1.1.67 | 0.45 | - |
6-thioguanine | - |
Homo sapiens | |
| 2.1.1.67 | 0.9 | - |
6-thioguanine | - |
Homo sapiens | |
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Release 2023.1 (January 2023)
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