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Literature summary extracted from

  • Lysaa, R.A.; Giverhaug, T.; Wold, H.L.; Aarbakke, J.
    Inhibition of human thiopurine methyltransferase by furosemide, bendroflumethiazide and trichlormethiazide (1996), Eur. J. Clin. Pharmacol., 49, 393-396.
    View publication on PubMed

Application

EC Number Application Comment Organism
2.1.1.67 medicine
-
 Homo sapiens

Cloned(Commentary)

EC Number Cloned (Comment) Organism
2.1.1.67
-
 Homo sapiens

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.1.1.67 5-amino-salicylic acid
-
 Homo sapiens
2.1.1.67 bendroflumethiazide
-
 Homo sapiens
2.1.1.67 benzoic acid benzoic acid derivatives Homo sapiens
2.1.1.67 Furosemide
-
 Homo sapiens
2.1.1.67 sulphasalazine
-
 Homo sapiens
2.1.1.67 trichlormethiazide
-
 Homo sapiens

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.1.1.67 S-adenosyl-L-methionine + a thiopurine Homo sapiens S-methylation, enzyme of major catabolic pathway of thiopurines S-adenosyl-L-homocysteine + a thiopurine S-methylether
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.1.1.67 Homo sapiens
-
 human
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.1.1.67 blood
-
 Homo sapiens
-
2.1.1.67 erythrocyte
-
 Homo sapiens
-
2.1.1.67 kidney
-
 Homo sapiens
-
2.1.1.67 liver
-
 Homo sapiens
-
2.1.1.67 lymphocyte
-
 Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.1.1.67 S-adenosyl-L-methionine + 6-mercaptopurine
-
 Homo sapiens S-adenosyl-L-homocysteine + 6-methylmercaptopurine
-
 ?
2.1.1.67 S-adenosyl-L-methionine + a thiopurine
-
 Homo sapiens S-adenosyl-L-homocysteine + a thiopurine S-methylether
-
 ?
2.1.1.67 S-adenosyl-L-methionine + a thiopurine S-methylation, enzyme of major catabolic pathway of thiopurines Homo sapiens S-adenosyl-L-homocysteine + a thiopurine S-methylether
-
 ?