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Literature summary extracted from

  • Morgan, S.E.; Kelley, M.R.; Pieper, R.O.
    The role of the carboxyl-terminal tail in human O6-methylguanine DNA methyltransferase substrate specificity and temperature sensitivity (1993), J. Biol. Chem., 268, 19802-19809.
    View publication on PubMed

Protein Variants

EC Number Protein Variants Comment Organism
2.1.1.63 additional information the 28-amino acid carboxy-terminal tail of the enzyme is not required for activity and modulates the rate of 6-O-methylguanine DNA methyltransferase repair at reduced temperatures and plays a role in substrate specificity Homo sapiens

Organism

EC Number Organism UniProt Comment Textmining
2.1.1.63 Homo sapiens
-
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.1.1.63 DNA containing 6-O-methylguanine + [protein]-L-cysteine
-
 Homo sapiens DNA lacking 6-O-methylguanine + [protein]-S-methyl-L-cysteine
-
 ?
2.1.1.63 additional information the 28-amino acid carboxy-terminal tail of the enzyme is not required for activity and modulates the rate of 6-O-methylguanine DNA methyltransferase repair at reduced temperatures and plays a role in substrate specificity Homo sapiens ?
-
 ?