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Literature summary extracted from

  • Koike, G.; Maki, H.; Takeya, H.; Hayakawa, H.; Sekiguchi, M.
    Purification, structure, and biochemical properties of human O6-methylguanine-DNA methyltransferase (1990), J. Biol. Chem., 265, 14754-14762.
    View publication on PubMed

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
2.1.1.63 19000
-
 gel filtration, glycerol density gradient sedimentation Homo sapiens
2.1.1.63 25000
-
 1 * 25000, SDS-PAGE Homo sapiens

Organism

EC Number Organism UniProt Comment Textmining
2.1.1.63 Homo sapiens
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
2.1.1.63
-
 Homo sapiens

Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
2.1.1.63 additional information
-
-
 Homo sapiens

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.1.1.63 DNA containing 4-O-methylthymine + [protein-L-cysteine
-
 Homo sapiens DNA lacking 4-O-methylthymine + [protein]-S-methyl-L-cysteine
-
 ?
2.1.1.63 DNA containing 6-O-methylguanine + [protein]-L-cysteine the methyltransferase protein itself accepts methyl groups from methylated DNA, one enzyme molecule accepts one methyl group Homo sapiens DNA lacking 6-O-methylguanine + [protein]-S-methyl-L-cysteine
-
 ?

Subunits

EC Number Subunits Comment Organism
2.1.1.63 monomer 1 * 25000, SDS-PAGE Homo sapiens