Literature summary extracted from

Nutt, C.L.; Costello, J.F.; Bambrick, L.L.; Yarosh, D.B.; Swinnen, L.J.; Chambers, A.F.; Cairncross, J.G.
O6-Methylguanine-DNA methyltransferase in tumors and cells of the oligodendrocyte lineage (1995), Can. J. Neurol. Sci., 22, 111-115.

Organism

EC Number	Organism	UniProt	Comment	Textmining
2.1.1.63	Homo sapiens	-	-	-
2.1.1.63	Rattus norvegicus	-	-	-

Source Tissue

EC Number	Source Tissue	Comment	Organism	Textmining
2.1.1.63	astrocyte	low activity	Homo sapiens	-
2.1.1.63	oligodendrocyte	-	Rattus norvegicus	-
2.1.1.63	oligodendroglioma cell	low 6-O-methylguanine-DNA methyltransferase activity may contribute to the chemosensitivity of some human oligodendrogliomas	Homo sapiens	-

Substrates and Products (Substrate)

EC Number	Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
2.1.1.63	DNA containing 6-O-methylguanine + [protein]-L-cysteine	-	Homo sapiens	DNA lacking 6-O-methylguanine + [protein]-S-methyl-L-cysteine	-	?
2.1.1.63	DNA containing 6-O-methylguanine + [protein]-L-cysteine	-	Rattus norvegicus	DNA lacking 6-O-methylguanine + [protein]-S-methyl-L-cysteine	-	?

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Release 2023.1 (January 2023)