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Literature summary extracted from

  • Liem, L.K.; Lim, A.; Li, B.F.L.
    Specificities of human, rat and E.coli O6-methylguanine-DNA methyltransferases towards the repair of O6-methyl and O6-ethylguanine in DNA (1994), Nucleic Acids Res., 22, 1613-1619.
    View publication on PubMedView publication on EuropePMC

Organism

EC Number Organism UniProt Comment Textmining
2.1.1.63 Escherichia coli
-
-
-
2.1.1.63 Homo sapiens
-
-
-
2.1.1.63 Rattus norvegicus
-
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.1.1.63 DNA containing 6-O-ethylguanine + [protein]-L-cysteine CGC(e6G)AGCTCGCG Escherichia coli DNA lacking 6-O-ethylguanine +[protein]-S-ethyl-L-cysteine
-
?
2.1.1.63 DNA containing 6-O-ethylguanine + [protein]-L-cysteine CGC(e6G)AGCTCGCG Homo sapiens DNA lacking 6-O-ethylguanine +[protein]-S-ethyl-L-cysteine
-
?
2.1.1.63 DNA containing 6-O-ethylguanine + [protein]-L-cysteine CGC(e6G)AGCTCGCG Rattus norvegicus DNA lacking 6-O-ethylguanine +[protein]-S-ethyl-L-cysteine
-
?
2.1.1.63 DNA containing 6-O-methylguanine + [protein]-L-cysteine
-
Homo sapiens DNA lacking 6-O-methylguanine + [protein]-S-methyl-L-cysteine
-
?
2.1.1.63 DNA containing 6-O-methylguanine + [protein]-L-cysteine CGC(m6G)CG and CGC(m6G)AGCTCGCG Escherichia coli DNA lacking 6-O-methylguanine + [protein]-S-methyl-L-cysteine
-
?
2.1.1.63 DNA containing 6-O-methylguanine + [protein]-L-cysteine CGC(m6G)CG and CGC(m6G)AGCTCGCG Rattus norvegicus DNA lacking 6-O-methylguanine + [protein]-S-methyl-L-cysteine
-
?

Turnover Number [1/s]

EC Number Turnover Number Minimum [1/s] Turnover Number Maximum [1/s] Substrate Comment Organism Structure
2.1.1.63 additional information
-
additional information second order repair rate constants of 6-O-methyl and 6-O-ethylguanine containing substrates Escherichia coli
2.1.1.63 additional information
-
additional information second order repair rate constants of 6-O-methyl and 6-O-ethylguanine containing substrates Homo sapiens
2.1.1.63 additional information
-
additional information second order repair rate constants of 6-O-methyl and 6-O-ethylguanine containing substrates Rattus norvegicus